Questiomycin A
Based on 1 Customer Validation
Questiomycin A (Phx-3) is a GRP78 (cytoprotective endoplasmic reticulum chaperone) degrader and enhances the anticancer activity of Sorafenib. Questiomycin A is also an antimicrobial/antibiotic that can be obtained from the metabolite of Pseudomonas chlororaphis HT66. Questiomycin A can be used in research on biological control of cancer and plant diseases.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.20%
- No. CAS: 1916-59-2
- Fòrmula: C12H8N2O2
- Peso molecular:212.20
-
Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
Anti-Infection Compound Library
HY-L002
-
Cell Cycle/DNA Damage Compound Library
HY-L004
-
Metabolism/Protease Compound Library
HY-L012
-
Natural Product Library
HY-L021
-
Anti-Cancer Compound Library
HY-L025
-
Anti-Aging Compound Library
HY-L034
-
Antibacterial Compound Library
HY-L049
-
Endoplasmic Reticulum Stress Compound Library
HY-L054
-
Cytoskeleton Compound Library
HY-L060
-
Antibiotics Library
HY-L067
-
Microbial Metabolite Library
HY-L084
-
Anti-Cancer Natural Product Library
HY-L107
-
Human Metabolite Library
HY-L123
-
Cuproptosis Compound Library
HY-L133
-
Metabolic Enzyme Compound Library
HY-L146
-
Highly Selective Inhibitors Library
HY-L158
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Natural Product Library Plus
HY-L021P
-
Natural Product and Natural Product-Like Compound Library
HY-L021M
-
Bioactive Compound Library
HY-L001
-
RO5 Drug-like Natural Product Library
HY-L200
-
High-Throughput Bioactive Compound Library
HY-L205
-
High-Throughput Natural Product Library
HY-L206
-
Mass Spectrometry Human Metabolite Library
HY-L215
-
Amino Acid Metabolite Compound Library
HY-L227
-
Chinese Baijiu Compound Library
HY-L241
-
Natural Product Diversity Scaffold Library
HY-L245
-
Fungal-Sourced Compound Library
HY-L253
-
Mass Spectrometry Natural Product Library
HY-L262
Ver todos los productos específicos de isoformas Antibiotic
More
Actividad biológica
|
Grp78 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | IC50 |
2 μM
Compound: 1
|
Compound concentration required to reduce the cell proliferation of human acute T-lymphoblastic leukemia CCRF-CEM cells by 50%, using MTT method
Compound concentration required to reduce the cell proliferation of human acute T-lymphoblastic leukemia CCRF-CEM cells by 50%, using MTT method
|
[PMID: 12431048] |
| CCRF-SB | IC50 |
1 μM
Compound: 1
|
Compound concentration required to reduce the cell proliferation of human acute B-lymphoblastic leukemia CCRF-SB cells by 50%, using MTT method
Compound concentration required to reduce the cell proliferation of human acute B-lymphoblastic leukemia CCRF-SB cells by 50%, using MTT method
|
[PMID: 12431048] |
| HeLa | IC50 |
2.7 μM
Compound: 1
|
Compound concentration required to reduce the cell proliferation of cervix carcinoma Hela cells by 50%, using MTT method
Compound concentration required to reduce the cell proliferation of cervix carcinoma Hela cells by 50%, using MTT method
|
[PMID: 12431048] |
| HEp-2 | IC50 |
1.8 μM
Compound: 1
|
Compound concentration required to reduce the cell proliferation of larynx carcinoma cells by 50%, using MTT method
Compound concentration required to reduce the cell proliferation of larynx carcinoma cells by 50%, using MTT method
|
[PMID: 12431048] |
Questiomycin A (3 µM; 24 h) induces cell death and downregulates GRP78 protein expression in HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HepG2 cells
-
Concentration:3 µM
-
Incubation Time:24 h
-
Result:Suppressed more than 50% of the GRP78 expression and induced cell death.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Nude mice (HepG2 cells xenograft model)[1].
-
Dosage:10 mg/kg
-
Administration:Intraperitoneal injection; once a day; 8 days.
-
Result:Stimulated Sorafenib-dependent antitumor activity.
Chemical Information
-
No. CAS 1916-59-2
-
Appearance Solid
-
Peso molecular 212.20
-
Fòrmula C12H8N2O2
-
Color Brown to black
-
SMILES
O=C1C(N)=CC2=NC3=C(C=CC=C3)OC2=C1
-
Synonyms
Phx-3
-
Structure Classification
-
Initial Source
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 12.5 mg/mL (58.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
-
Ficha de datos (274 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. Machihara K, et al. Questiomycin A stimulates sorafenib-induced cell death via suppression of glucose-regulated protein 78. Biochem Biophys Res Commun. 2017 Oct 7;492(1):33-40. [Content Brief]
[2]. Guo S, et al. Production of Antibacterial Questiomycin A in Metabolically Engineered Pseudomonas chlororaphis HT66. J Agric Food Chem. 2022 Jun 29;70(25):7742-7750. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7125 mL | 23.5627 mL | 47.1254 mL | 117.8134 mL |
| 5 mM | 0.9425 mL | 4.7125 mL | 9.4251 mL | 23.5627 mL | |
| 10 mM | 0.4713 mL | 2.3563 mL | 4.7125 mL | 11.7813 mL | |
| 15 mM | 0.3142 mL | 1.5708 mL | 3.1417 mL | 7.8542 mL | |
| 20 mM | 0.2356 mL | 1.1781 mL | 2.3563 mL | 5.8907 mL | |
| 25 mM | 0.1885 mL | 0.9425 mL | 1.8850 mL | 4.7125 mL | |
| 30 mM | 0.1571 mL | 0.7854 mL | 1.5708 mL | 3.9271 mL | |
| 40 mM | 0.1178 mL | 0.5891 mL | 1.1781 mL | 2.9453 mL | |
| 50 mM | 0.0943 mL | 0.4713 mL | 0.9425 mL | 2.3563 mL |
Questiomycin A Related Classifications
HY-N8439 Related Classifications
Powered by Bioz