Sinapaldehyde
Based on 1 Customer Validation
Sinapaldehyde is a methoxyphenol and a selective COX-2 inhibitor (IC50: 47.8 µM) that can be extracted from various plants. Sinapaldehyde has antibacterial, anti-inflammatory, and antioxidant activities. Sinapaldehyde can scavenge DPPH free radicals (IC50: 172 μM). Sinapaldehyde is active against both Gram-negative and Gram-positive bacteria.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.71%
- No. CAS: 4206-58-0
- Fòrmula: C11H12O4
- Peso molecular:208.21
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
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Help & FAQs
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Actividad biológica
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COX-2 47.8 μM (IC50) |
IL-6 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>100 μM
Compound: 31
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Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
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[PMID: 21696954] |
| LoVo | IC50 |
33 μM
Compound: 31
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Cytotoxicity against human LoVo cells after 72 hrs by MTT assay
Cytotoxicity against human LoVo cells after 72 hrs by MTT assay
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[PMID: 21696954] |
| PC-3 | IC50 |
63 μM
Compound: 31
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Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
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[PMID: 21696954] |
| SK-MEL-28 | IC50 |
66 μM
Compound: 31
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Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay
Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay
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[PMID: 21696954] |
| U-373MG ATCC | IC50 |
56 μM
Compound: 31
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Cytotoxicity against human U373 cells after 72 hrs by MTT assay
Cytotoxicity against human U373 cells after 72 hrs by MTT assay
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[PMID: 21696954] |
Sinapaldehyde (1-100 μM; 0-25 h) can inhibit the generation of NO and ROS, the production of IL-6 and TNF-α, the expression of iNOS and COX-2, as well as the phosphorylation of p65, ERK1/2 and SAPK/JNK in LPS (HY-D1056)-induced RAW 264.7 cells[1].
Sinapaldehyde has MIC values of 64, 128, 128, 128, 64 and 128 μg/mL for Pseudomonas aeruginosa, Escherichia coli, Salmonella enterica serovar Typhimurium, Bacillus cereus, Staphylococcus aureus and MRSA, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LPS (HY-D1056) treated RAW 264.7 cells
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Concentration:0, 3, 10, 30 and 100 μM
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Incubation Time:Pretreated with 1 h, then co-incubation for 24 h
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Result:Inhibited the levels of iNOS and COX-2.
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Cell Line:LPS (HY-D1056) treated RAW 264.7 cells
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Concentration:100 μM
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Incubation Time:0, 5, 10 and 20 min
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Result:Inhibited the level of pERK1/2 at 10 min.
Inhibited the level of pSAPK/JNK after 20 min.
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Cell Line:LPS (HY-D1056) treated RAW 264.7 cells
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Concentration:0, 3, 10, 30 and 100 μM
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Incubation Time:15 min
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Result:Inhibited the level of p-p65 in a dose-dependent manner.
Chemical Information
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No. CAS 4206-58-0
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Appearance Solid
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Peso molecular 208.21
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Fòrmula C11H12O4
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Color White to yellow
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SMILES
O=C/C=C/C1=CC(OC)=C(O)C(OC)=C1
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvente y solubilidad
DMSO : 50 mg/mL (240.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (12.01 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (12.01 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Baek SH, et al. Anti-Inflammatory Activity and ROS Regulation Effect of Sinapaldehyde in LPS-Stimulated RAW 264.7 Macrophages. Molecules. 2020 Sep 7;25(18):4089. [Content Brief]
[2]. Waranya Lakornwong, et al. A New Coruleoellagic Acid Derivative From Stems of Rhodamnia Dumetorum. Nat Prod Res. 2018 Jul;32(14):1653-1659. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.8028 mL | 24.0142 mL | 48.0284 mL | 120.0711 mL |
| 5 mM | 0.9606 mL | 4.8028 mL | 9.6057 mL | 24.0142 mL | |
| 10 mM | 0.4803 mL | 2.4014 mL | 4.8028 mL | 12.0071 mL | |
| 15 mM | 0.3202 mL | 1.6009 mL | 3.2019 mL | 8.0047 mL | |
| 20 mM | 0.2401 mL | 1.2007 mL | 2.4014 mL | 6.0036 mL | |
| 25 mM | 0.1921 mL | 0.9606 mL | 1.9211 mL | 4.8028 mL | |
| 30 mM | 0.1601 mL | 0.8005 mL | 1.6009 mL | 4.0024 mL | |
| 40 mM | 0.1201 mL | 0.6004 mL | 1.2007 mL | 3.0018 mL | |
| 50 mM | 0.0961 mL | 0.4803 mL | 0.9606 mL | 2.4014 mL | |
| 60 mM | 0.0800 mL | 0.4002 mL | 0.8005 mL | 2.0012 mL | |
| 80 mM | 0.0600 mL | 0.3002 mL | 0.6004 mL | 1.5009 mL | |
| 100 mM | 0.0480 mL | 0.2401 mL | 0.4803 mL | 1.2007 mL |
Sinapaldehyde Related Classifications
HY-N1312 Related Classifications
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