ST7612AA1
ST7612AA1 is a histone deacetylase (HDAC) inhibitor that controls chromatin condensation and DNA transcription by removing acetyl groups from histones. ST7612AA1 is also a potent HIV reactivation inducer, and its reactivation activity is exerted without activating or proliferating CD4+T cells, and can be used in the study of HIV reactivation strategies and elimination of viral reservoirs.
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- No. CAS: 1428535-92-5
- Fòrmula: C20H27N3O4S
- Peso molecular:405.51
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.075 μM
Compound: 117, ST7612
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Cytotoxicity against human HCT116 cells after 24 hrs by SRB assay
Cytotoxicity against human HCT116 cells after 24 hrs by SRB assay
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[PMID: 25233084] |
| L6 | IC50 |
189 nM
Compound: 3
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Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
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[PMID: 25563890] |
| NCI-H460 | IC50 |
0.005 μM
Compound: 117, ST7612
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Inhibition of HDAC-mediated histone H4 deacetylation in human NCI-H460 cells after 3 hrs by Western blot analysis
Inhibition of HDAC-mediated histone H4 deacetylation in human NCI-H460 cells after 3 hrs by Western blot analysis
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[PMID: 25233084] |
| NCI-H460 | IC50 |
0.07 μM
Compound: 117, ST7612
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Cytotoxicity against human NCI-H460 cells after 24 hrs by SRB assay
Cytotoxicity against human NCI-H460 cells after 24 hrs by SRB assay
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[PMID: 25233084] |
| NCI-H460 | IC50 |
0.2 μM
Compound: 117, ST7612
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Inhibition of HDAC-mediated tubulin deacetylation in human NCI-H460 cells after 3 hrs by Western blot analysis
Inhibition of HDAC-mediated tubulin deacetylation in human NCI-H460 cells after 3 hrs by Western blot analysis
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[PMID: 25233084] |
| NCI-H460 | IC50 |
66 nM
Compound: 3
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Cytotoxicity against human NCI-H460 cells
Cytotoxicity against human NCI-H460 cells
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[PMID: 25563890] |
Chemical Information
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No. CAS 1428535-92-5
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Peso molecular 405.51
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Fòrmula C20H27N3O4S
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SMILES
CC(SCCCCC[C@H](NC([C@@H](CC1)NC1=O)=O)C(NC2=CC=CC=C2)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ST7612AA1 Related Classifications
HY-12926 Related Classifications
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