Sugiol
(Synonyms: (+)-Sugiol; 10-Deoxoxanthoperol)
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Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages.
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- Pureza: 99.88%
- No. CAS: 511-05-7
- Fòrmula: C20H28O2
- Peso molecular:300.44
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
Descripciòn
Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages[1].
IC50 & Target
[1]|
ERK1 |
ERK2 |
p38 MAPK |
JNK1 |
JNK2 |
IL-1β |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
<50 μg/mL
Compound: 4
|
Inhibitory activity against human A549 lung tumor cell proliferation
Inhibitory activity against human A549 lung tumor cell proliferation
|
[PMID: 15808460] |
| A549 | GI50 |
79.8 μM
Compound: 13
|
Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay
|
[PMID: 24210499] |
| A549 | IC50 |
>10 μM
Compound: 17
|
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTS assay
|
[PMID: 33978415] |
| BEAS-2B | IC50 |
>10 μM
Compound: 17
|
Cytotoxicity against human BEAS2B cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human BEAS2B cells assessed as reduction in cell viability after 48 hrs by MTS assay
|
[PMID: 33978415] |
| BXPC-3 | GI50 |
36.08 μM
Compound: 13
|
Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay
|
[PMID: 24210499] |
| HCT-116 | GI50 |
<50 μg/mL
Compound: 4
|
Growth inhibitory activity against human HCT116 colon tumor cell line
Growth inhibitory activity against human HCT116 colon tumor cell line
|
[PMID: 15808460] |
| HL-60 | GI50 |
68.64 μM
Compound: 13
|
Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay
|
[PMID: 24210499] |
| HL-60 | IC50 |
>10 μM
Compound: 17
|
Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTS assay
|
[PMID: 33978415] |
| K562 | IC50 |
6.7 μM
Compound: Sugiol
|
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
|
[PMID: 30684866] |
| MCF7 | IC50 |
>10 μM
Compound: 17
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTS assay
|
[PMID: 33978415] |
| MDA-MB-231 | GI50 |
<50 μg/mL
Compound: 4
|
Growth inhibitory activity against human MDA-MB-231 breast tumor cell line
Growth inhibitory activity against human MDA-MB-231 breast tumor cell line
|
[PMID: 15808460] |
| MIA PaCa-2 | IC50 |
17.9 μM
Compound: 10
|
Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay
Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay
|
[PMID: 21775156] |
| MRC5 | GI50 |
>100 μM
Compound: 13
|
Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay
|
[PMID: 24210499] |
| NCI-H23 | GI50 |
<50 μg/mL
Compound: 4
|
Growth inhibitory activity against human NCI-H23 lung tumor cell line
Growth inhibitory activity against human NCI-H23 lung tumor cell line
|
[PMID: 15808460] |
| PANC-1 | GI50 |
87.94 μM
Compound: 13
|
Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay
|
[PMID: 24210499] |
| PC-3 | GI50 |
>100 μM
Compound: 13
|
Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay
|
[PMID: 24210499] |
| SMMC-7721 | IC50 |
>10 μM
Compound: 17
|
Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability after 48 hrs by MTS assay
|
[PMID: 33978415] |
| SW480 | IC50 |
>10 μM
Compound: 17
|
Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTS assay
Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTS assay
|
[PMID: 33978415] |
| SW-620 | GI50 |
<50 μg/mL
Compound: 4
|
Growth inhibitory activity against human SW620 colon tumor cell line
Growth inhibitory activity against human SW620 colon tumor cell line
|
[PMID: 15808460] |
| Vero | IC50 |
24.6 μM
Compound: 2
|
Trypanocidal activity against intracellular amastigote form of Trypanosoma cruzi IRHOD/CO/2008/SN3 in african green monkey Vero cells
Trypanocidal activity against intracellular amastigote form of Trypanosoma cruzi IRHOD/CO/2008/SN3 in african green monkey Vero cells
|
[PMID: 25462275] |
| Vero | IC50 |
45.4 μM
Compound: 2
|
Cytotoxicity against african green monkey Vero cells after 72 hrs
Cytotoxicity against african green monkey Vero cells after 72 hrs
|
[PMID: 25462275] |
In Vitro
Sugiol (5-30 μM; 30 min) inhibits TNF-α and proIL-1β/IL-1β protein production in J774A.1 cells[1].
Sugiol (5-30 μM; 30 min) inhibits MAPK activation, suppresses ERK1/2, JUNK1/2, and p38 phosphorylation in LPS-induced J774A.1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis[1]
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Cell Line:J774A.1 macrophages cells stimulated with LPS
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Concentration:5 μM, 10 μM, 20 μM, and 30 μM
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Incubation Time:30 min
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Result:Completely inhibited ERK1/2 phosphorylation at 30 μM, and effectively inhibited JNK1/2 and p38 phosphorylation.
Chemical Information
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No. CAS 511-05-7
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Appearance Solid
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Peso molecular 300.44
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Fòrmula C20H28O2
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Color White to off-white
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SMILES
O=C1C2=C(C=C(O)C(C(C)C)=C2)[C@@]3(C)CCCC(C)(C)[C@]3([H])C1
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Synonyms
(+)-Sugiol; 10-Deoxoxanthoperol
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
Select Batch:
Pureza:
99.98%
Assay:
99.98%
ee.:
99.98%
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Ficha de datos (272 KB)
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SDS (251 KB)
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- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
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Sugiol Related Classifications
HY-N1195 Related Classifications
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