2. Gene
  3. Dyrk1a - dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a Gene

Dyrk1a - dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as mmb; Dyrk; Mnbh; Mp86; Gm10783; D16Ertd272e; D16Ertd493e; 2310043O08Rik

Gene ID: 13548 | Gene type: protein coding

About Dyrk1a

Chromosome 16: 94,370,869-94,496,376 forward strand.GRCm39:CM001009.3

This gene has 6 transcripts (splice variants), 236 orthologues, 12 paralogues and is associated with 26 phenotypes. Ubiquitous expression in thymus adult (RPKM 12.2), whole brain E14.5 (RPKM 1.) and 28 other tissues.

Summary

Enables several functions, including identical protein binding activity; protein self-association; and Tau Protein binding activity. Involved in several processes, including negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of microtubule polymerization; and protein phosphorylation. Acts upstream of or within negative regulation of mRNA splicing, via spliceosome and peptidyl-tyrosine phosphorylation. Located in several cellular components, including axon; cytoskeleton; and dendrite. Part of ribonucleoprotein complex. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Used to study Down syndrome. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant non-syndromic intellectual disability 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A). [provided by Alliance of Genome Resources, Apr 2022]

Dyrk1a Products(6)

mRNA Protein Name
NM_001402792.1 NP_001389721.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 3
NM_001402793.1 NP_001389722.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 4
NM_001402791.1 NP_001389720.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1
NM_007890.2 NP_031916.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1
NM_001113389.1 NP_001106860.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1
NM_001347731.2 NP_001334660.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 2

Dyrk1a Protein Structure

PKc_DYRK1

PKc_DYRK1: cd14226 (147 - 483)

  • 0
  • 200
  • 400
  • 600
  • 763 a.a.
Protein Preferred Names Protein Names

dual specificity tyrosine-phosphorylation-regulated kinase 1A

dual specificity YAK1-related kinase

protein kinase minibrain homolog

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-105309 GSK-626616 Inhibitor 99.68% Phase 1
Pre-clinical Phase
Bioactive Molecules (50)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-115470 CLK-IN-T3 Inhibitor 98.63% Unkown
HY-111380 EHT 1610 Inhibitor 98.16% Unkown
HY-112296 T025 98.84% Unkown
HY-132308 DYRK1-IN-1 Inhibitor 99.62% Unkown
HY-142295 GNF2133 Inhibitor 98.49% Unkown
HY-15569 NU6102 Inhibitor 99.23% Unkown
HY-101298 Paprotrain Inhibitor 99.87% Unkown
HY-12838 Mirk-IN-1 Inhibitor 99.53% Unkown
HY-101029 MBM-55 99.94% Unkown
HY-108476 INDY Inhibitor 99.51% Unkown
HY-111379 EHT 5372 Inhibitor 98.12% Unkown
HY-15951 ML167 Inhibitor 98.62% Unkown
HY-146221 Dyrk1A-IN-5 Inhibitor 98.56% Unkown
HY-135906 CK2/ERK8-IN-1 ≥99.0% Unkown
HY-129492 GNF4877 Inhibitor 99.32% Unkown
HY-12828A KH-CB20 Inhibitor 99.80% Unkown
HY-147066 Dyrk1A-IN-4 Inhibitor 99.90% Unkown
HY-144290 ARN25068 Inhibitor 99.66% Unkown
HY-149262 CLK1-IN-3 98.03% Unkown
HY-117049 Leucettine L41 Inhibitor 98.70% Unkown
HY-110052 TBCA Inhibitor 99.60% Unkown
HY-147060 Dyrk1A-IN-3 Inhibitor 99.96% Unkown
HY-156816 ON 108600 Inhibitor 99.73% Unkown
HY-128758 DYRKs-IN-1 Inhibitor / Unkown
HY-128758A DYRKs-IN-1 hydrochloride Inhibitor 99.70% Unkown
HY-101029A MBM-55S / Unkown
HY-128759 DYRKs-IN-2 Inhibitor / Unkown
HY-129449 AnnH31 Inhibitor 99.91% Unkown
HY-139830 Dyrk1A-IN-1 Inhibitor / Unkown
HY-142295A GNF2133 hydrochloride Inhibitor / Unkown
HY-144614 JH-XVII-10 / Unkown
HY-144617 JH-XIV-68-3 Inhibitor / Unkown
HY-144695 Dyrk1A/α-synuclein-IN-1 Inhibitor / Unkown
HY-144696 Dyrk1A/α-synuclein-IN-2 Inhibitor / Unkown
HY-144826 ZDWX-25 Inhibitor / Unkown
HY-146337 Dyrk1A/B-IN-1 Inhibitor / Unkown
HY-146586 Haspin-IN-1 Inhibitor / Unkown
HY-146587 Haspin-IN-2 Inhibitor / Unkown
HY-147760 Dyrk1A-IN-2 Inhibitor / Unkown
HY-150537 AChE/GSK-3β-IN-1 Inhibitor / Unkown
HY-152183 FINDY Inhibitor / Unkown
HY-155723 Leucettinib-92 Inhibitor / Unkown
HY-157995 Dyrk1A-IN-7 Inhibitor / Unkown
HY-77324S 4-(Trifluoromethyl)aniline-d4 Inhibitor / Unkown
HY-N2892 Aristolactam A IIIa Inhibitor / Unkown
HY-RS04094 DYRK1A Human Pre-designed siRNA Set A / Unkown
HY-RS04095 Dyrk1a Mouse Pre-designed siRNA Set A / Unkown
HY-RS04096 Dyrk1a Rat Pre-designed siRNA Set A / Unkown
HY-122989 Aristolactam BIII Inhibitor / Unkown
HY-162107 Dyrk1A-IN-6 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dyrk1a NCBI NCBI:1859