Hdac11 - histone deacetylase 11 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 232232

About Hdac11

Chromosome 6: 91,133,647-91,151,674 forward strand.GRCm39:CM000999.3

This gene has 7 transcripts (splice variants), 198 orthologues, 10 paralogues and is associated with 4 phenotypes. Ubiquitous expression in testis adult (RPKM 59.4), cerebellum adult (RPKM 42.4) and 27 other tissues.

Summary

Predicted to enable histone deacetylase activity. Predicted to be involved in histone deacetylation and oligodendrocyte development. Predicted to be located in nucleus and plasma membrane. Predicted to be part of histone deacetylase complex. Orthologous to human HDAC11 (histone deacetylase 11). [provided by Alliance of Genome Resources, Apr 2022]

Hdac11 Products (1)

mRNA Protein Name
NM_144919.2 NP_659168.1 histone deacetylase 11

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17568773 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hdac11 Protein Structure

HDAC_classIV

HDAC_classIV: cd09993 (34 - 318)

  • 0
  • 100
  • 200
  • 300
  • 347 a.a.
Protein Preferred Names Protein Names

histone deacetylase 11

  • HD11

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10221 Vorinostat Inhibitor 99.96% Yes
HY-109015 Tucidinostat Inhibitor 98.74% Unkown
HY-12164 Mocetinostat Inhibitor 99.68% Yes
HY-14842 Givinostat Inhibitor 98.67% Yes
HY-13322 Pracinostat Inhibitor 99.80% Yes
HY-14842B Givinostat hydrochloride monohydrate Inhibitor 99.63% Yes
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Yes

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-150109 Purinostat mesylate Inhibitor 99.45% Phase 3
HY-15433 Quisinostat Inhibitor 99.71% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2

Pre-clinical Phase

Bioactive Molecules (59)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13428 Tubacin Inhibitor 98.71% Unkown
HY-18998 LMK-235 Inhibitor 99.61% Unkown
HY-112285 FT895 Inhibitor 99.84% Unkown
HY-128918 SIS17 Inhibitor 99.43% Unkown
HY-16699 Nexturastat A Inhibitor 98.69% Unkown
HY-145757 Elevenostat Inhibitor 95.07% Unkown
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Unkown
HY-16012A Domatinostat Inhibitor 99.34% Unkown
HY-115475 SW-100 Inhibitor 99.93% Unkown
HY-126330 SS-208 Inhibitor 99.00% Unkown
HY-135714 Bavarostat Inhibitor 99.51% Unkown
HY-172157 HDAC11-IN-2 Inhibitor 99.52% Unkown
HY-176542 TD034 Inhibitor 99.77% Unkown
HY-143412 MIR002 Inhibitor 99.0% Unkown
HY-114483 AES-135 Inhibitor 98.68% Unkown
HY-143411 GEM144 Inhibitor / Unkown
HY-173444 HDAC11-IN-3 Inhibitor 99.70% Unkown
HY-110280 MC1742 Inhibitor 98.95% Unkown
HY-182019 HDAC11-IN-5 Inhibitor 98.25% Unkown
HY-138831 AES-350 Inhibitor 99.30% Unkown
HY-157740 XSJ-10 Inhibitor 95.16% Unkown
HY-178970 HDAC11-IN-4 Inhibitor 95.0% Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-176868 Rodin-C Inhibitor / Unkown
HY-173076 HDAC11-IN-1 Inhibitor / Unkown
HY-157481 HDAC1-IN-6 Inhibitor / Unkown
HY-161778 ZG-126 Inhibitor / Unkown
HY-179019 HDAC-IN-94 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-151263 G4/HDAC-IN-1 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor 98.71% Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-143877 NN-390 Inhibitor / Unkown
HY-180811 ALK/HDAC-IN-2 Inhibitor / Unkown
HY-159171 sEH/HDAC6-IN-2 Inhibitor / Unkown
HY-181579 HDAC6-IN-74 Inhibitor / Unkown
HY-184203 SM-06-09 Inhibitor / Unkown
HY-157889 ZINC000028464438 Inhibitor / Unkown
HY-181009 HDAC-IN-98 Inhibitor 98.36% Unkown
HY-163207 sEH/HDAC6-IN-1 Inhibitor / Unkown
HY-170379 HDAC-IN-84 Inhibitor / Unkown
HY-152173 HDAC-IN-51 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-183560 HDAC6-IN-82 Inhibitor / Unkown
HY-182717 FT234 Inhibitor / Unkown
HY-161350 ALK/HDAC-IN-1 Inhibitor / Unkown
HY-162630 HDAC6-IN-44 Inhibitor / Unkown
HY-150772 Tubulin/HDAC-IN-1 Inhibitor / Unkown
HY-180214 HDAC6-IN-69 Inhibitor / Unkown
HY-184574 HDAC-IN-104 Inhibitor / Unkown
HY-147966 HDAC-IN-43 Inhibitor / Unkown
HY-162658 Leuxinostat Inhibitor / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-174302 PIM-1/HDAC-IN-2 Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-179272 Wee1/HDAC-IN-1 Inhibitor / Unkown
HY-15433B Quisinostat hydrochloride Inhibitor / Unkown
HY-169400 HDACs/EZH2-IN-1 Inhibitor / Unkown
HY-175030 TNI-97 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdac11 NCBI NCBI:79885