Ret - ret proto-oncogene Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24716

About Ret

Primary_assembly 4: 151,326,431-151,368,176 reverse strand.mRatBN7.2:CM026977.1

This gene has 1 transcript (splice variant), 205 orthologues, 54 paralogues and is associated with 55 phenotypes. Biased expression in Brain (RPKM 34.7), Lung (RPKM 33.7) and 7 other tissues.

Summary

Predicted to enable calcium ion binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including innervation; positive regulation of neuron maturation; and retina development in camera-type eye. Located in several cellular components, including early endosome; membrane raft; and neuronal cell body. Biomarker of Parkinsonism; brain ischemia; and pheochromocytoma. Human ortholog(s) of this gene implicated in Hirschsprung's disease; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; multiple endocrine neoplasia type 2B; and pheochromocytoma. Orthologous to human RET (RET proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]

Ret Products (2)

mRNA Protein Name
NM_001110099.1 NP_001103569.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform b precursor
NM_012643.2 NP_036775.2 proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in innervation IMP
IMP: Inferred from mutant phenotype
18501516 RGD
involved in positive regulation of neuron maturation IMP
IMP: Inferred from mutant phenotype
18501516 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
15837122 RGD
involved in retina development in camera-type eye IEP
IEP: Inferred from expression pattern
16650834 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
20877310 RGD
located in dendrite IDA
IDA: Inferred from direct assay
20877310 RGD
located in early endosome IDA
IDA: Inferred from direct assay
20877310 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
20877310 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ret Protein Structure

RET_CLD1

RET_CLD1: pfam17756 (28 - 153)

Cadherin

Cadherin: pfam00028 (172 - 247)

RET_CLD3

RET_CLD3: pfam17812 (265 - 379)

RET_CLD4

RET_CLD4: pfam17813 (407 - 506)

PTKc_RET

PTKc_RET: cd05045 (723 - 1012)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1115 a.a.
Protein Preferred Names Protein Names

proto-oncogene tyrosine-protein kinase receptor Ret

  • Ret gene for receptor tyrosin

  • Ret proto-oncogene (multiple endocrine neoplasia MEN2A MEN2B and medullary thyroid carcinoma 1 Hirschsprung disease)

  • receptor tyrosine kinase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10981 Lenvatinib Inhibitor 99.75% Yes
HY-10331 Regorafenib Inhibitor 99.97% Yes
HY-10981A Lenvatinib mesylate Inhibitor 99.91% Yes
HY-114370 Selpercatinib Inhibitor 99.83% Yes
HY-112301 Pralsetinib Inhibitor 99.98% Yes
HY-10331A Regorafenib monohydrate Inhibitor 99.94% Yes
HY-13308 Regorafenib Hydrochloride Inhibitor 99.58% Yes
HY-10331B Regorafenib mesylate Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Phase
HY-10206 Amuvatinib Inhibitor 99.40% Phase 2
HY-132846 Vepafestinib Inhibitor 98.61% Phase 2
HY-145565 Enbezotinib Inhibitor 99.50% Phase 2
HY-149451 SYHA1815 Inhibitor / Phase 2
HY-10032 PF 477736 Inhibitor 99.04% Phase 1
HY-100459 GSK3179106 Inhibitor 99.81% Phase 1
HY-139590 Zeteletinib Inhibitor 98.31% Phase 1
HY-116116 Tafetinib Inhibitor 96.20% Phase 1
HY-178061 APS03118 Inhibitor / Phase 1
HY-149413 FHND5071 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (125)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15002 AST 487 Inhibitor 98.90% Unkown
HY-10410 TG101209 Inhibitor 98.81% Unkown
HY-101963 AD80 Inhibitor 99.88% Unkown
HY-18840 BBT594 Inhibitor 99.81% Unkown
HY-156135 NSC194598 Inhibitor 98.90% Unkown
HY-153175 BT44 Activator 98.87% Unkown
HY-162565 CDD-2807 Inhibitor 99.52% Unkown
HY-N10889 Sominone Activator 99.96% Unkown
HY-136534 RET V804M-IN-1 Inhibitor 99.36% Unkown
HY-13342AS Apatinib-d8 free base 92.5% Unkown
HY-P10044 IGF1Rtide 99.53% Unkown
HY-18507 AD57 Inhibitor 98.27% Unkown
HY-110193 SPP-86 Inhibitor 99.87% Unkown
HY-101246 RPI-1 Inhibitor 98.47% Unkown
HY-10981S Lenvatinib-d4 Inhibitor 99.59% Unkown
HY-112301A trans-Pralsetinib Inhibitor 98.06% Unkown
HY-15769 WHI-P180 Inhibitor 99.84% Unkown
HY-U00437 Pz-1 Inhibitor 99.90% Unkown
HY-133551 WF-47-JS03 Inhibitor 99.63% Unkown
HY-148742 RET-IN-21 Inhibitor 97.00% Unkown
HY-133553 RET-IN-3 Inhibitor 99.51% Unkown
HY-18317 JNJ-38158471 Inhibitor 97.02% Unkown
HY-34595 Pyrazoloadenine Inhibitor 99.98% Unkown
HY-10331S Regorafenib-d3 Inhibitor 98.0% Unkown
HY-10206A Amuvatinib hydrochloride Inhibitor / Unkown
HY-132193 RET-IN-4 Inhibitor / Unkown
HY-139590A Zeteletinib hemiadipate Inhibitor / Unkown
HY-117873A KBP-7018 hydrochloride Inhibitor / Unkown
HY-E70771 RET L730I Recombinant Human Active Protein Kinase / Unkown
HY-147563 RET-IN-17 Inhibitor / Unkown
HY-E70767 RET G691S Recombinant Human Active Protein Kinase / Unkown
HY-151987 RET-IN-20 Inhibitor / Unkown
HY-143545 RET-IN-8 Inhibitor / Unkown
HY-170373 RET ligand-1 Inhibitor / Unkown
HY-14979A ML786 dihydrochloride Inhibitor / Unkown
HY-170856 RET ligand-4 Ligand / Unkown
HY-178964 PROTAC RET Degrader 1 Degrader / Unkown
HY-170926 CQ1373 Inhibitor / Unkown
HY-180551 ZW-6-052 Degrader / Unkown
HY-144422 RET-IN-15 Inhibitor / Unkown
HY-E70769 RET G810R Recombinant Human Active Protein Kinase / Unkown
HY-183783 PROTAC RET Degrader 2 Degrader / Unkown
HY-170809 RET-IN-29 Inhibitor / Unkown
HY-144131 RET-IN-11 Inhibitor / Unkown
HY-170019 RET-IN-28 Inhibitor / Unkown
HY-159824 Soxataltinib Inhibitor / Unkown
HY-14979 ML786 Inhibitor / Unkown
HY-168867 RD-23 Degrader / Unkown
HY-180550 ZW-18-116 Degrader / Unkown
HY-156471 RET-IN-26 Inhibitor / Unkown
HY-164413 CLM3 Inhibitor / Unkown
HY-E70774 RET R749T Recombinant Human Active Protein Kinase / Unkown
HY-10981S2 Lenvatinib-15N,d4 Inhibitor 98.01% Unkown
HY-151945 TRK II-IN-1 Inhibitor / Unkown
HY-176937 HSN608 Inhibitor / Unkown
HY-171146 HSN748 Inhibitor / Unkown
HY-178786 RET-IN-31 Inhibitor / Unkown
HY-E70859 RET L790F Recombinant Human Active Protein Kinase / Unkown
HY-168105 RET-IN-27 Inhibitor / Unkown
HY-184396 GR2-128 Inhibitor / Unkown
HY-170855A YW-N-7 TFA Degrader / Unkown
HY-182741 RET-IN-32 Inhibitor / Unkown
HY-183729 RET-IN-34 Inhibitor / Unkown
HY-E70776 RET S891A Recombinant Human Active Protein Kinase / Unkown
HY-143615 RET-IN-10 Inhibitor / Unkown
HY-E70768 RET G810C Recombinant Human Active Protein Kinase / Unkown
HY-148015 Enbezotinib (enantiomer) Inhibitor 99.72% Unkown
HY-176885A CDD-2212 Inhibitor / Unkown
HY-E70770 RET G810S Recombinant Human Active Protein Kinase / Unkown
HY-183931 NPA101.3 Inhibitor / Unkown
HY-161775 RET/TRKA-IN-1 Inhibitor / Unkown
HY-145024 RET-IN-6 Inhibitor / Unkown
HY-149099 RET-IN-22 Inhibitor / Unkown
HY-176885 CDD-2211 Inhibitor / Unkown
HY-E70781 RET Y806H Recombinant Human Active Protein Kinase / Unkown
HY-181895 PROTAC HyTTD Degrader-1 Degrader / Unkown
HY-143546 RET-IN-9 Inhibitor / Unkown
HY-18507A AD57 hydrochloride Inhibitor / Unkown
HY-174245 RET-IN-30 Inhibitor / Unkown
HY-10331S1 Regorafenib-13C,d3 Inhibitor / Unkown
HY-153676 RET-IN-23 Inhibitor / Unkown
HY-172952 LRRK2-IN-17 Inhibitor / Unkown
HY-E70789 BCR-RET Recombinant Human Active Protein Kinase / Unkown
HY-183684 RET-IN-33 Inhibitor / Unkown
HY-182354 VEGFR2-IN-84 Inhibitor / Unkown
HY-181918 PLM-101-C3-NHBoc / Unkown
HY-147564 RET-IN-18 Inhibitor / Unkown
HY-112950 RET-IN-1 Inhibitor / Unkown
HY-E70772 RET L730M Recombinant Human Active Protein Kinase / Unkown
HY-170852 QZ2135 Degrader / Unkown
HY-149539 PLM-101 Inhibitor / Unkown
HY-E70775 RET R813Q Recombinant Human Active Protein Kinase / Unkown
HY-149415 Multi-kinase-IN-5 Inhibitor / Unkown
HY-120214 TAS05567 / Unkown
HY-10981S1 Lenvatinib-d5 Inhibitor / Unkown
HY-141896 RET-IN-7 Inhibitor 98.00% Unkown
HY-E70779 RET V804M Recombinant Human Active Protein Kinase / Unkown
HY-153941 RET-IN-24 Inhibitor / Unkown
HY-151377 RET-IN-19 Inhibitor / Unkown
HY-E70777 RET V804E Recombinant Human Active Protein Kinase / Unkown
HY-E70766 RET E762Q Recombinant Human Active Protein Kinase / Unkown
HY-115541 BRD4-IN-41 / Unkown
HY-146710 RET-IN-16 Inhibitor / Unkown
HY-168868 RET ligand-2 Inhibitor / Unkown
HY-114588 Tafetinib analogue 1 Inhibitor / Unkown
HY-176884 CDD-2110 Inhibitor / Unkown
HY-156113 RET-IN-25 Inhibitor / Unkown
HY-144170 RET-IN-14 Inhibitor / Unkown
HY-179308 RET ligand-5 Degrader / Unkown
HY-144029 RET-IN-13 Inhibitor / Unkown
HY-170854 RET Ligand-Linker Conjugate-1 Ligand / Unkown
HY-E70778 RET V804L Recombinant Human Active Protein Kinase / Unkown
HY-170853 RET ligand-3 Degrader / Unkown
HY-145023 RET-IN-5 Inhibitor / Unkown
HY-E70780 RET Y791F Recombinant Human Active Protein Kinase / Unkown
HY-174993 FHND5071 (1H) Inhibitor / Unkown
HY-146680 FLT3/ITD-IN-4 Inhibitor / Unkown
HY-E70773 RET M918T Recombinant Human Active Protein Kinase / Unkown
HY-164549 XMD15-44 Inhibitor / Unkown
HY-18817 AFG210 Inhibitor / Unkown
HY-W759629 Selpercatinib-d3 Inhibitor / Unkown
HY-15769A WHI-P180 hydrochloride Inhibitor / Unkown
HY-117873 KBP-7018 Inhibitor / Unkown
HY-164482 HG-6-63-01 Inhibitor / Unkown
HY-144030 RET-IN-12 Inhibitor / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99828 Cofetuzumab Inhibitor 99.31% Unkown
HY-P992232 Anti-GFRA4 Antibody (scFv) Inhibitor / Unkown
HY-P992009 Anti-GFRA4 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ret NCBI NCBI:5979