2. Gene
  3. Ret - ret proto-oncogene Gene

Ret - ret proto-oncogene Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 24716 | Gene type: protein coding

About Ret

Primary_assembly 4: 151,326,431-151,368,176 reverse strand.mRatBN7.2:CM026977.1

This gene has 1 transcript (splice variant), 205 orthologues, 54 paralogues and is associated with 55 phenotypes. Biased expression in Brain (RPKM 34.7), Lung (RPKM 33.7) and 7 other tissues.

Summary

Predicted to enable calcium ion binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including innervation; positive regulation of neuron maturation; and retina development in camera-type eye. Located in several cellular components, including early endosome; membrane raft; and neuronal cell body. Biomarker of Parkinsonism; brain ischemia; and pheochromocytoma. Human ortholog(s) of this gene implicated in Hirschsprung's disease; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; multiple endocrine neoplasia type 2B; and pheochromocytoma. Orthologous to human RET (RET proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]

Ret Products(2)

mRNA Protein Name
NM_001110099.1 NP_001103569.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform b precursor
NM_012643.2 NP_036775.2 proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor

Ret Protein Structure

RET_CLD1

RET_CLD1: pfam17756 (28 - 153)

Cadherin

Cadherin: pfam00028 (172 - 247)

RET_CLD3

RET_CLD3: pfam17812 (265 - 379)

RET_CLD4

RET_CLD4: pfam17813 (407 - 506)

PTKc_RET

PTKc_RET: cd05045 (723 - 1012)

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  • 1115 a.a.
Protein Preferred Names Protein Names

proto-oncogene tyrosine-protein kinase receptor Ret

Ret gene for receptor tyrosin

Ret proto-oncogene (multiple endocrine neoplasia MEN2A MEN2B and medullary thyroid carcinoma 1 Hirschsprung disease)

receptor tyrosine kinase

Related Agents

Approval
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10981 Lenvatinib Inhibitor 99.84% Yes
HY-10331 Regorafenib Inhibitor 99.93% Yes
HY-114370 Selpercatinib Inhibitor 99.87% Yes
HY-112301 Pralsetinib Inhibitor 99.98% Yes
HY-10981A Lenvatinib mesylate Inhibitor 99.86% Yes
HY-13308 Regorafenib Hydrochloride Inhibitor 99.58% Yes
HY-10331A Regorafenib monohydrate Inhibitor 99.96% Yes
HY-10331B Regorafenib mesylate Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-10206 Amuvatinib Inhibitor 99.47% Phase 2
HY-132846 Vepafestinib Inhibitor 98.84% Phase 2
HY-10206A Amuvatinib hydrochloride Inhibitor / Phase 2
HY-10032 PF 477736 Inhibitor 99.21% Phase 1
HY-100459 GSK3179106 Inhibitor 98.41% Phase 1
Pre-clinical Phase
Bioactive Molecules (60)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10410 TG101209 Inhibitor 99.22% Unkown
HY-15002 AST 487 Inhibitor 99.42% Unkown
HY-124401 BT-13 Agonist 99.59% Unkown
HY-18840 BBT594 Inhibitor 99.86% Unkown
HY-101963 AD80 Inhibitor 99.88% Unkown
HY-133551 WF-47-JS03 Inhibitor 99.63% Unkown
HY-15769 WHI-P180 Inhibitor 99.62% Unkown
HY-139590 Zeteletinib Inhibitor 99.06% Unkown
HY-112301A trans-Pralsetinib Inhibitor 96.07% Unkown
HY-145565 Enbezotinib Inhibitor 99.50% Unkown
HY-156135 NSC194598 Inhibitor ≥98.0% Unkown
HY-110193 SPP-86 Inhibitor 99.62% Unkown
HY-136534 RET V804M-IN-1 Inhibitor 98.22% Unkown
HY-153175 BT44 Activator 99.08% Unkown
HY-10981S Lenvatinib-d4 Inhibitor 99.59% Unkown
HY-U00437 Pz-1 Inhibitor 99.92% Unkown
HY-133553 RET-IN-3 Inhibitor 99.51% Unkown
HY-18507 AD57 Inhibitor 98.08% Unkown
HY-18317 JNJ-38158471 Inhibitor 97.02% Unkown
HY-34595 Pyrazoloadenine Inhibitor 99.98% Unkown
HY-139590A Zeteletinib hemiadipate Inhibitor / Unkown
HY-132193 RET-IN-4 Inhibitor / Unkown
HY-144422 RET-IN-15 Inhibitor / Unkown
HY-10981S1 Lenvatinib-d5 Inhibitor / Unkown
HY-145024 RET-IN-6 Inhibitor / Unkown
HY-117873 KBP-7018 Inhibitor / Unkown
HY-149539 PLM-101 Inhibitor / Unkown
HY-151987 RET-IN-20 Inhibitor / Unkown
HY-146710 RET-IN-16 Inhibitor / Unkown
HY-13342AS Apatinib-d8 free base 92.56% Unkown
HY-153941 RET-IN-24 Inhibitor / Unkown
HY-112950 RET-IN-1 Inhibitor / Unkown
HY-153676 RET-IN-23 Inhibitor / Unkown
HY-156113 RET-IN-25 Inhibitor / Unkown
HY-149413 FHND5071 Inhibitor / Unkown
HY-14979A ML786 dihydrochloride Inhibitor / Unkown
HY-143546 RET-IN-9 Inhibitor / Unkown
HY-151377 RET-IN-19 Inhibitor / Unkown
HY-156471 RET-IN-26 Inhibitor / Unkown
HY-146680 FLT3/ITD-IN-4 Inhibitor / Unkown
HY-144170 RET-IN-14 Inhibitor / Unkown
HY-120214 TAS05567 / Unkown
HY-144029 RET-IN-13 Inhibitor / Unkown
HY-141896 RET-IN-7 Inhibitor 98.00% Unkown
HY-147563 RET-IN-17 Inhibitor / Unkown
HY-149099 RET-IN-22 Inhibitor / Unkown
HY-143615 RET-IN-10 Inhibitor / Unkown
HY-151945 TRK II-IN-1 Inhibitor / Unkown
HY-144131 RET-IN-11 Inhibitor / Unkown
HY-148015 Enbezotinib (enantiomer) Inhibitor 99.72% Unkown
HY-18507A AD57 hydrochloride Inhibitor / Unkown
HY-149415 Multi-kinase-IN-5 Inhibitor / Unkown
HY-143545 RET-IN-8 Inhibitor / Unkown
HY-145023 RET-IN-5 Inhibitor / Unkown
HY-147564 RET-IN-18 Inhibitor / Unkown
HY-10331S1 Regorafenib-13C,d3 Inhibitor / Unkown
HY-15769A WHI-P180 hydrochloride Inhibitor / Unkown
HY-148742 RET-IN-21 Inhibitor / Unkown
HY-116116 Tafetinib Inhibitor / Unkown
HY-144030 RET-IN-12 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ret NCBI NCBI:5979
Canis familiaris Ret NCBI NCBI:403494
Macaca fascicularis Ret NCBI NCBI:102135879
Mus musculus Ret NCBI NCBI:19713
Susscrofa domestica Ret NCBI
Macaca mulatta Ret NCBI NCBI:703466