Cd38 - CD38 molecule Gene

Also Known as ADPRC 1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25668

About Cd38

Primary_assembly 14: 67,172,063-67,211,986 reverse strand.mRatBN7.2:CM026987.1

This gene has 2 transcripts (splice variants), 281 orthologues, 1 paralogue and is associated with 8 phenotypes. Biased expression in Spleen (RPKM 249.7), Lung (RPKM 118.2) and 8 other tissues.

Summary

Enables NAD+ nucleosidase activity. Involved in several processes, including blood vessel diameter maintenance; long-term synaptic depression; and negative regulation of bone resorption. Located in basolateral plasma membrane; nucleus; and secretory granule membrane. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human CD38 (CD38 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd38 Products (1)

mRNA Protein Name
NM_013127.2 NP_037259.1 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NAD+ nucleotidase, cyclic ADP-ribose generating IDA
IDA: Inferred from direct assay
11733184 RGD
Biological Process GO Annotation Evidence References Source
involved in artery smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
21431168 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
14998907 RGD
involved in long-term synaptic depression IMP
IMP: Inferred from mutant phenotype
10097163 RGD
involved in negative regulation of bone resorption IDA
IDA: Inferred from direct assay
10477767 RGD
involved in negative regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
19696022 RGD
involved in positive regulation of cell growth IMP
IMP: Inferred from mutant phenotype
18719074 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
19696022 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
18719074 RGD
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
9664081 RGD
involved in positive regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
18524860 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
11399650 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
14998907 RGD
involved in response to hormone IDA
IDA: Inferred from direct assay
9325179 RGD
involved in response to hydroperoxide IDA
IDA: Inferred from direct assay
12893282 RGD
involved in response to hypoxia IDA
IDA: Inferred from direct assay
12111041 RGD
involved in response to interleukin-1 IEP
IEP: Inferred from expression pattern
11399650 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
14998907 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
11399650 RGD
Cellular Component GO Annotation Evidence References Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
21784055 RGD
located in nuclear membrane IDA
IDA: Inferred from direct assay
11733184 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cd38 Protein Structure

Rib_hydrolayse

Rib_hydrolayse: pfam02267 (57 - 286)

  • 0
  • 100
  • 200
  • 303 a.a.
Protein Preferred Names Protein Names

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

  • 2'-phospho-ADP-ribosyl cyclase

  • 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase

  • 2'-phospho-cyclic-ADP-ribose transferase

  • ADP-ribosyl cyclase 1

  • CD38 antigen (ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase)

  • CD38H

  • cADPr hydrolase 1

  • cyclic ADP-ribose hydrolase 1

Recombinant Cd38 Proteins

Cat. No. Product Name Accession Purity
HY-P70077 CD38 Protein, Rat (HEK293, His) Q64244 (W45-V303) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72897 CD38 Protein, Rat (HEK293, Fc) Q64244 (W45-V303) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9915 Daratumumab 99.10% Unkown
HY-P9976 Isatuximab Inhibitor 98.5% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P10563 Noraramtide / Phase 1
Inhibitory Antibodies (8)
Cat. No. Product Name Effect
Purity Phase
HY-P99616 Felzartamab Inhibitor 99.34% Phase 3
HY-P99730 Mezagitamab Inhibitor 99.76% Phase 3
HY-P991715 Sanritatug Inhibitor 99.62% Phase 3
HY-P99744 Modakafusp alfa Inhibitor 96.22% Phase 2
HY-P990037 Erzotabart Inhibitor 99.00% Phase 2
HY-P990747 Lumrotatug Inhibitor 97.00% Phase 2
HY-P991913 CID-103 Inhibitor / Phase 2
HY-P991183 SAR-442257 Ligand ≥99.0% Phase 1

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-123999 CD38 inhibitor 1 99.83% Unkown
HY-N0640 Kuromanin chloride Inhibitor 99.83% Unkown
HY-150508 MK-0159 Inhibitor 99.72% Unkown
HY-129997 Luteolinidin chloride Inhibitor 99.91% Unkown
HY-144987 RBN013209 98.63% Unkown
HY-134358A Ara-F-NAD+ sodium Inhibitor 99.59% Unkown
HY-186178 CD38-IN-6 Inhibitor 99.96% Unkown
HY-144988 CD38 inhibitor 2 98.81% Unkown
HY-134358 Ara-F-NAD+ Inhibitor / Unkown
HY-182345 NOTA-MK0159 Inhibitor / Unkown
HY-184021 A-8531 Inhibitor / Unkown
HY-184206 A-3190 Inhibitor / Unkown
HY-171417 6-Alkyne-F-araNAD Inhibitor / Unkown
HY-181543 CVN14 Inhibitor / Unkown
HY-164628 CD38-IN-5 Inhibitor / Unkown
HY-184493 CD38-IN-7 Inhibitor / Unkown
HY-119648A (E/Z)-CCR-11 Inhibitor 98.00% Unkown
Inhibitory Antibodies (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P9915A Daratumumab (Anti-CD38) 97.94% Unkown
HY-P990273 Anti-Mouse CD38 Antibody (NIMR5) Inhibitor 95.00% Unkown
HY-P9976A Isatuximab (anti-CD38) 98.44% Unkown
HY-P991490 ISB2001 Inhibitor 99.17% Unkown
HY-P991461 AMG-424 Inhibitor 99.32% Unkown
HY-P991914 FTL004 Inhibitor / Unkown
HY-P992455 SAR442085 Inhibitor / Unkown
HY-P991462 GBR-1342 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd38 NCBI NCBI:952