Il18 - interleukin 18 Gene

Also Known as IL-18; IL-1 gamma

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29197

Summary

Predicted to enable cytokine activity and interleukin-18 receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; positive regulation of cell population proliferation; and positive regulation of cytokine production. Located in apical plasma membrane; cytoplasm; and extracellular space. Used to study brain edema; fatty liver disease; heart disease; status epilepticus; and vasculitis. Biomarker of several diseases, including cardiac arrest; ischemia (multiple); lung disease (multiple); perinatal necrotizing enterocolitis; and urinary tract Infection. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18). [provided by Alliance of Genome Resources, Apr 2022]

Il18 Products (1)

mRNA Protein Name
NM_019165.2 NP_062038.2 interleukin-18

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12034039 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
12490070 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
12684057 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
11739527 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
18320471 RGD
involved in cellular response to parathyroid hormone stimulus IEP
IEP: Inferred from expression pattern
18165223 RGD
involved in cellular response to peptide hormone stimulus IMP
IMP: Inferred from mutant phenotype
12490070 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
18547159 RGD
involved in cellular response to type II interferon IEP
IEP: Inferred from expression pattern
18547159 RGD
involved in detection of mechanical stimulus involved in sensory perception of pain IDA
IDA: Inferred from direct assay
19853379 RGD
involved in digestive tract morphogenesis IEP
IEP: Inferred from expression pattern
21088234 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
24412291 RGD
involved in lung development IEP
IEP: Inferred from expression pattern
18952566 RGD
involved in negative regulation of neutrophil apoptotic process IMP
IMP: Inferred from mutant phenotype
20844839 RGD
involved in negative regulation of peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
22001439 RGD
involved in osteoblast differentiation IEP
IEP: Inferred from expression pattern
18165223 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
22001439 RGD
involved in positive regulation of blood vessel remodeling IDA
IDA: Inferred from direct assay
19717152 RGD
involved in positive regulation of chemokine production IMP
IMP: Inferred from mutant phenotype
19497959 RGD
involved in positive regulation of collagen biosynthetic process IDA
IDA: Inferred from direct assay
20644901 RGD
involved in positive regulation of hepatocyte proliferation IDA
IDA: Inferred from direct assay
24412291 RGD
involved in positive regulation of interleukin-1 beta production IEP
IEP: Inferred from expression pattern
17623049 RGD
involved in positive regulation of interleukin-8 production IDA
IDA: Inferred from direct assay
18547159 RGD
involved in positive regulation of male germ cell proliferation IDA
IDA: Inferred from direct assay
16002206 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
17188500 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
22636674 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
22636674 RGD
involved in positive regulation of superoxide anion generation IMP
IMP: Inferred from mutant phenotype
19497959 RGD
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
17623049 RGD
involved in positive regulation of vascular permeability IMP
IMP: Inferred from mutant phenotype
11739527 RGD
involved in response to hyperoxia IEP
IEP: Inferred from expression pattern
19672068 RGD
involved in response to hypoxia IMP
IMP: Inferred from mutant phenotype
12122053 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
11086064 RGD
involved in sleep IDA
IDA: Inferred from direct assay
11506998 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
12032269 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
16002206 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-18

  • IFN-gamma-inducing factor

  • interferon gamma-inducing factor

  • interleukin-1 gamma

Recombinant Il18 Proteins

Cat. No. Product Name Accession Purity
HY-P7210 IL-18 Protein, Rat P97636-1 (H37-S194) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-132591A Inclisiran sodium 99.08% Unkown
HY-132591 Inclisiran 99.48% Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-13205 Belnacasan Inhibitor 99.99% Phase 2
HY-149478 JT002 Inhibitor 99.54% Phase 2
HY-19676 Pralnacasan Inhibitor 99.83% Phase 2
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P991083 MAS825 Inhibitor 95.83% Phase 3
HY-P99491 Camoteskimab Inhibitor 98.56% Phase 2
HY-P990591 GSK-1070806 Inhibitor 99.84% Phase 2

Pre-clinical Phase

Bioactive Molecules (53)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16990 Ac-YVAD-cmk Inhibitor 99.63% Unkown
HY-101092 QS-21-Api Activator 99.73% Unkown
HY-113298 Citraconic acid Inhibitor 99.08% Unkown
HY-150751 ODN TTAGGG 99.87% Unkown
HY-143221 AS-Inclisiran sodium 96.58% Unkown
HY-155876 NVP-DFV890 Antagonist 99.97% Unkown
HY-172162 LC-04-045 99.56% Unkown
HY-130413 Protectin D1 99.10% Unkown
HY-169996 NP3-253 Inhibitor 99.78% Unkown
HY-164426 HEI3090 Activator 99.00% Unkown
HY-123879 BAA473 99.93% Unkown
HY-156413 NLRP3 agonist 1 99.47% Unkown
HY-P10939A Ac-DMLD-CMK TFA Inhibitor 98.44% Unkown
HY-102019 NSC61610 Inhibitor 99.89% Unkown
HY-150742A ODN 2336 sodium 97.80% Unkown
HY-NP192 Sericin 0% Unkown
HY-W176629 Hydrocotarnine Inhibitor 99.70% Unkown
HY-160793 NSC80734 Inhibitor 98.08% Unkown
HY-172941 VEN-02XX Inhibitor 99.66% Unkown
HY-158024A (S)-NDT-19795 Inhibitor / Unkown
HY-RS06709 IL18BP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-147660 IMMH001 Agonist 98.10% Unkown
HY-111662 Fc 11a-2 Inhibitor 99.75% Unkown
HY-130480 Fructose-arginine Inhibitor 98.32% Unkown
HY-150742 ODN 2336 Agonist 90.74% Unkown
HY-173234 GI-Y2 Inhibitor / Unkown
HY-P4890A Relaxin H3 (human) TFA / Unkown
HY-RS06708 IL18 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174631 Human IL18 mRNA 90.9% Unkown
HY-113298R Citraconic acid (Standard) Inhibitor / Unkown
HY-125577 VRT-18858 Inhibitor / Unkown
HY-171589 NLRP3-IN-77 Inhibitor / Unkown
HY-175640 Troponin-IN-1 Inhibitor / Unkown
HY-178053 AHR agonist 10 / Unkown
HY-179635 GSTO1-IN-6 Inhibitor / Unkown
HY-185311 NEK7 degrader-3 / Unkown
HY-N6189 MBL-1 Inhibitor / Unkown
HY-P10939 Ac-DMLD-CMK Inhibitor / Unkown
HY-P4890 Relaxin H3 (human) / Unkown
HY-RS06710 IL18R1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06711 IL18RAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-119337 CE-2072 Inhibitor / Unkown
HY-174630 Human IL18R1 mRNA / Unkown
HY-185102 ZBP1 PROTAC-1 Inhibitor / Unkown
HY-208735 NEK7 degrader-5 / Unkown
HY-RS16685 Il18 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18310 Il18bp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19262 Il18r1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20633 Il18rap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23120 Il18 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24788 Il18bp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25751 Il18r1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27142 Il18rap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990220 Anti-Mouse IL-18 Antibody (YIGIF74-1G7) Inhibitor 97.12% Unkown
HY-P990312 ABT-325 Inhibitor 99.75% Unkown
HY-P992046 Anti-IL-18 Antibody Inhibitor / Unkown
HY-P992238 Anti-IL-18RAP Antibody / Unkown
HY-P992239 Anti-IL-18Rα Antibody / Unkown
HY-P992335 COM503 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il18 NCBI NCBI:3606