VAMP3 - vesicle associated membrane protein 3 Gene

Also Known as CEB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9341

About VAMP3

Cytogenetic location: 1p36.23 Genomic coordinates (GRCh38): 1:7,771,296-7,781,432 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues and 10 paralogues. Ubiquitous expression in fat (RPKM 43.9), lung (RPKM 35.7) and 25 other tissues.

Summary

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to Other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or Thrombin stimulation. [provided by RefSeq, Jul 2008]

VAMP3 Products (1)

mRNA	Protein	Name
NM_004781.4	NP_004772.1	vesicle-associated membrane protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12130530	GOA

Biological Process GO Annotation	Evidence	References	Source
NOT involved in mucus secretion	IMP IMP: Inferred from mutant phenotype	22144578	GOA
involved in negative regulation of secretion by cell	IDA IDA: Inferred from direct assay	12130530	GOA
NOT involved in positive regulation of immunoglobulin production	IMP IMP: Inferred from mutant phenotype	24055037	GOA
NOT involved in regulation of histamine secretion by mast cell	IMP IMP: Inferred from mutant phenotype	18253931	GOA
involved in retrograde transport, endosome to Golgi	IDA IDA: Inferred from direct assay	18195106	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SNARE complex	IDA IDA: Inferred from direct assay	12130530	GOA
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	19478182	GOA
located in cytosol	IDA IDA: Inferred from direct assay	22589474	GOA
located in intracellular membrane-bounded organelle	IDA IDA: Inferred from direct assay	18253931	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	19061864	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VAMP3 Protein Structure

Synaptobrevin

0
100 a.a.

Protein Preferred Names	Protein Names
vesicle-associated membrane protein 3	VAMP-3

VAMP3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VAMP3	Q15836	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	32296183
Intra	VAMP3	Q15836	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	VAMP3	Q15836	RMDN3	Homo sapiens	Q96TC7	Y2H Array	32296183
Intra	VAMP3	Q15836	RMDN3	Homo sapiens	Q96TC7	Validated Y2H	32296183
Intra	VAMP3	Q15836	RMDN3	Homo sapiens	Q96TC7	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	NEMP1	Homo sapiens	O14524-2	Y2H Array	32296183
Intra	VAMP3	Q15836	NEMP1	Homo sapiens	O14524-2	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	VAMP3	Q15836	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	VAMP3	Q15836	PTGES	Homo sapiens	O14684	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	PTGES	Homo sapiens	O14684	Y2H Array	32296183
Intra	VAMP3	Q15836	MGST2	Homo sapiens	Q99735	Validated Y2H	32296183
Intra	VAMP3	Q15836	MGST2	Homo sapiens	Q99735	Y2H Array	32296183
Intra	VAMP3	Q15836	MGST2	Homo sapiens	Q99735	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	VAMP3	Q15836	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	VAMP3	Q15836	BSCL2	Homo sapiens	J3KQ12	Y2H Array	32296183
Intra	VAMP3	Q15836	BSCL2	Homo sapiens	J3KQ12	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	VAMP3	Q15836	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	VAMP3	Q15836	TMEM35A	Homo sapiens	Q53FP2	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	TMEM35A	Homo sapiens	Q53FP2	Validated Y2H	32296183
Intra	VAMP3	Q15836	TMEM35A	Homo sapiens	Q53FP2	Y2H Array	32296183
Intra	VAMP3	Q15836	TMPPE	Homo sapiens	Q6ZT21	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	TMPPE	Homo sapiens	Q6ZT21	Validated Y2H	32296183
Intra	VAMP3	Q15836	TMPPE	Homo sapiens	Q6ZT21	Y2H Array	32296183
Intra	VAMP3	Q15836	VEGFD	Homo sapiens	O43915	BFG-2H	27107012
Intra	VAMP3	Q15836	STX2	Homo sapiens	P32856-2	Y2H Array	32296183
Intra	VAMP3	Q15836	STX2	Homo sapiens	P32856-2	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	AIG1	Homo sapiens	Q9NVV5-2	Y2H Array	32296183
Intra	VAMP3	Q15836	AIG1	Homo sapiens	Q9NVV5-2	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	AIG1	Homo sapiens	Q9NVV5-2	Validated Y2H	32296183
Intra	VAMP3	Q15836	AHNAK2	Homo sapiens	Q8IVF2-3	Y2H Array	32296183
Intra	VAMP3	Q15836	AHNAK2	Homo sapiens	Q8IVF2-3	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	AHNAK2	Homo sapiens	Q8IVF2-3	Validated Y2H	32296183
Intra	VAMP3	Q15836	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	VAMP3	Q15836	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	VAMP3	Q15836	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	VAMP3	Q15836	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	CLEC14A	Homo sapiens	Q86T13	Validated Y2H	32296183
Intra	VAMP3	Q15836	CLEC14A	Homo sapiens	Q86T13	Y2H Array	32296183
Intra	VAMP3	Q15836	CLEC14A	Homo sapiens	Q86T13	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	TM4SF20	Homo sapiens	Q53R12	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	TM4SF20	Homo sapiens	Q53R12	Validated Y2H	32296183
Intra	VAMP3	Q15836	TM4SF20	Homo sapiens	Q53R12	Y2H Array	32296183
Intra	VAMP3	Q15836	TMEM52B	Homo sapiens	Q4KMG9	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	TMEM52B	Homo sapiens	Q4KMG9	Validated Y2H	32296183
Intra	VAMP3	Q15836	TMEM52B	Homo sapiens	Q4KMG9	Y2H Array	32296183
Intra	VAMP3	Q15836	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	VAMP3	Q15836	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	VAMP3	Q15836	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	VAMP3	Q15836	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	VAMP3	Q15836	FAM174A	Homo sapiens	Q8TBP5	Y2H Array	32296183
Intra	VAMP3	Q15836	FAM174A	Homo sapiens	Q8TBP5	Validated Y2H	32296183
Intra	VAMP3	Q15836	FAM174A	Homo sapiens	Q8TBP5	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	FAM210B	Homo sapiens	Q96KR6	Validated Y2H	32296183
Intra	VAMP3	Q15836	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
Intra	VAMP3	Q15836	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
Intra	VAMP3	Q15836	TMEM86B	Homo sapiens	Q8N661	Y2H Array	32296183
Intra	VAMP3	Q15836	TMEM86B	Homo sapiens	Q8N661	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	VAMP3	Q15836	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	VAMP3	Q15836	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	VAMP3	Q15836	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	VAMP3	Q15836	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	VAMP3	Q15836	COMT	Homo sapiens	P21964	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	COMT	Homo sapiens	P21964	Y2H Array	32296183
Intra	VAMP3	Q15836	EMP3	Homo sapiens	P54852	PLA	30614533
Intra	VAMP3	Q15836	EMP3	Homo sapiens	P54852	BiFC	30614533
Intra	VAMP3	Q15836	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	VAMP3	Q15836	GORAB	Homo sapiens	Q5T7V8	Y2H Array	32296183
Intra	VAMP3	Q15836	GORAB	Homo sapiens	Q5T7V8	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	GORAB	Homo sapiens	Q5T7V8	Validated Y2H	32296183
Intra	VAMP3	Q15836	SAR1A	Homo sapiens	Q9NR31	Validated Y2H	32296183
Intra	VAMP3	Q15836	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
Intra	VAMP3	Q15836	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	VAMP3	Q15836	KCNK5	Homo sapiens	O95279	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	KCNK5	Homo sapiens	O95279	Y2H Array	32296183
Intra	VAMP3	Q15836	SNAP29	Homo sapiens	O95721	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	SNAP29	Homo sapiens	O95721	Y2H Array	32296183
Intra	VAMP3	Q15836	SNAP29	Homo sapiens	O95721	Anti Tag CoIP	35271311
Intra	VAMP3	Q15836	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	VAMP3	Q15836	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	VAMP3	Q15836	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	TM4SF19	Homo sapiens	Q96DZ7	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	TM4SF19	Homo sapiens	Q96DZ7	Validated Y2H	32296183
Intra	VAMP3	Q15836	TM4SF19	Homo sapiens	Q96DZ7	Y2H Array	32296183
Intra	VAMP3	Q15836	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	VAMP3	Q15836	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	STX1A	Homo sapiens	Q16623	Validated Y2H	32296183
Intra	VAMP3	Q15836	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	VAMP3	Q15836	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	VAMP3	Q15836	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	VAMP3	Q15836	CLDN7	Homo sapiens	O95471	Y2H Array	32296183
Intra	VAMP3	Q15836	CLDN7	Homo sapiens	O95471	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	STX4	Homo sapiens	Q12846	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	STX4	Homo sapiens	Q12846	Anti Tag CoIP	35271311
Intra	VAMP3	Q15836	STX4	Homo sapiens	Q12846	Validated Y2H	25416956
Intra	VAMP3	Q15836	STX4	Homo sapiens	Q12846	Y2H Array	25416956
Intra	VAMP3	Q15836	STX4	Homo sapiens	Q12846	Y2H Array	32296183
Intra	VAMP3	Q15836	VSIR	Homo sapiens	Q9H7M9	Validated Y2H	32296183
Intra	VAMP3	Q15836	VSIR	Homo sapiens	Q9H7M9	Y2H Array	32296183
Intra	VAMP3	Q15836	VSIR	Homo sapiens	Q9H7M9	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	SNAP23	Homo sapiens	O00161	Pull Down	26359495
Intra	VAMP3	Q15836	SNAP23	Homo sapiens	O00161	Anti Tag CoIP	35271311
Intra	VAMP3	Q15836	SNAP23	Homo sapiens	O00161	Anti Bait CoIP	24373201
Intra	VAMP3	Q15836	BCL2L13	Homo sapiens	Q9BXK5	Y2H Array	25416956
Intra	VAMP3	Q15836	CIAO2A	Homo sapiens	Q9H5X1	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	CIAO2A	Homo sapiens	Q9H5X1	Y2H Array	32296183
Intra	VAMP3	Q15836	CIAO2A	Homo sapiens	Q9H5X1	Validated Y2H	32296183
Intra	VAMP3	Q15836	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	VAMP3	Q15836	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	VAMP3	Q15836	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	VAMP3	Q15836	BSND	Homo sapiens	Q8WZ55	Validated Y2H	32296183
Intra	VAMP3	Q15836	BSND	Homo sapiens	Q8WZ55	Y2H Array	32296183
Intra	VAMP3	Q15836	BSND	Homo sapiens	Q8WZ55	Y2H Prey Pooling	32296183
Intra	VAMP3	Q15836	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	VAMP3	Q15836	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	VAMP3	Q15836	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	VAMP3	Q15836	PLEKHO1	Homo sapiens	Q53GL0	Validated Y2H	32296183
Intra	VAMP3	Q15836	PLEKHO1	Homo sapiens	Q53GL0	Y2H Array	32296183
Intra	VAMP3	Q15836	PLEKHO1	Homo sapiens	Q53GL0	Y2H Prey Pooling	32296183
Cross	VAMP3	Q15836	Picalm	Rattus norvegicus	O55012	Pull Down	22118466

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant VAMP3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76121	VAMP3 Protein, Human (His)	Q15836 (M1-K77)	≥ 95%, as determined by reducing SDS-PAGE.

VAMP3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82127	Cellubrevin Antibody (YA1872)	WB, ICC/IF, FC, IP	Human

Related Diseases

Diseases	Alias
Tetanus	Lockjaw Clostridial Tetanus Infection Due To Clostridium Tetani Lock-Jaw

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P10809	VAMP	Inhibitor	98.13%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15595	VAMP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22908	Vamp3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29422	Vamp3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	VAMP3	VGNC	VGNC:36757
Rattus norvegicus	VAMP3	RGD	RGD:61880
Canis familiaris	VAMP3	VGNC	VGNC:48223
Felis catus	VAMP3	VGNC	VGNC:107688
Macaca mulatta	VAMP3	VGNC	VGNC:106528
Mus musculus	VAMP3	MGD	MGI:1321389
Others	VAMP3	NCBI