CM-444
CM-444 is inhibitor for HDAC (IC50 is 6 nM-0.6 μM) and DNA methyltransferases (DNMT, IC50 is 1.8-2.3 μM). CM-444 is an inducer for the differentiation of acute myeloid leukemia cells. CM-444 exhibits anti-leukemic activity and improves the survival rate in mouse models.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2256079-52-2
- 分子式: C27H30N6O5
- 分子量:518.56
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
DNA Methyltransferase アイソフォーム固有の製品をすべて表示
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生物活性
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HDAC1 6.55 nM (IC50) |
HDAC10 15 nM (IC50) |
HDAC3 18 nM (IC50) |
HDAC2 51 nM (IC50) |
HDAC5 59 nM (IC50) |
HDAC4 62 nM (IC50) |
HDAC8 83 nM (IC50) |
HDAC9 90 nM (IC50) |
HDAC7 120 nM (IC50) |
HDAC6 531 nM (IC50) |
HDAC11 567.5 nM (IC50) |
DNMT3A 1.8 μM (IC50) |
DNMT1 2.2 μM (IC50) |
DNMT3B 2.3 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| JJN-3 | GI50 |
482 nM
Compound: 12a
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Antiproliferative activity against human JJN-3 cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay
Antiproliferative activity against human JJN-3 cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay
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[PMID: 33661013] |
| MM1.S | GI50 |
32 nM
Compound: 12a
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Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay
Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay
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[PMID: 33661013] |
| NCI-H929 | GI50 |
103 nM
Compound: 12a
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Antiproliferative activity against human NCI-H929 cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay
Antiproliferative activity against human NCI-H929 cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay
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[PMID: 33661013] |
化学情報
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CAS 番号 2256079-52-2
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分子量 518.56
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分子式 C27H30N6O5
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SMILES
O=C(C1=CN=C(N2CCC(CNC3=CC(C4=CC=C(C)O4)=NC5=CC(OC)=C(OC)C=C35)CC2)N=C1)NO
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CM-444 関連分類
HY-163803 関連分類
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