Creatine monohydrate
Based on 6 publication(s) in Google Scholar
Creatine monohydrate, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.98%
- CAS 番号: 6020-87-7
- 分子式: C4H11N3O3
- 分子量:149.15
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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- 純度とドキュメンテーション
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MedChemExpress（MCE）の使用を引用している文献 Creatine monohydrate
More- Cell Res. 2026 Jul;36(7):513-530. [Abstract]
- Proc Natl Acad Sci U S A. 2025 Sep 9;122(36):e2426135122. [Abstract]
- Cancer Immunol Res. 2025 Jun 4;13(6):939-956. [Abstract]
- Cell Rep. 2025 Sep 1;44(9):116139. [Abstract]
- Toxicol Appl Pharmacol. 2022 Apr 15:441:115971. [Abstract]
- Connect Tissue Res. 2025 Mar;66(2):73-86. [Abstract]
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Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
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Human Endogenous Metabolite |
Microbial Metabolite |
Creatine monohydrate (10-20 mM, 1-3 weeks) promotes the cell growth, differentiation and mineralization of osteoblast-like cells[2].
Creatine monohydrate (0.1-10 mM, 2-24 h) scanvages the free radicals, protects the DNA especially mtDNA from oxidative damage[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Creatine monohydrate (0.03-0.3 mg/kg, drinking water for 8 weeks) stimulates the PI3K/AKT signaling pathways, promotes the protein synthesis and muscle hypertrophy, thereby promoting the performance of short-duration, high-intensity exercise in rats models[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 6020-87-7
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性状 Solid
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分子量 149.15
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分子式 C4H11N3O3
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Color White to off-white
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SMILES
O=C(O)CN(C(N)=N)C.[H]O[H]
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (6)
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Journal Impact Factor
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Most Recent
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Cell Res
Compression-induced metabolic adaptation drives confined tumor cell migration and distant metastasis via malate-dependent microtubule reinforcement. [Abstract]2026 Jul;36(7):513-530. PMID: 42151565 -
Proc Natl Acad Sci U S A
Structural insights into the substrate uptake and inhibition of the human creatine transporter (hCRT). [Abstract]2025 Sep 9;122(36):e2426135122. PMID: 40892912
Creatine monohydrate purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2025 Sep 9;122(36):e2426135122. [Abstract]
SPR analysis showed Creatine (25 μM) binding to hCRT, with a dissociation constant (KD) of 3.2 μM.
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Cancer Immunol Res
In Situ Delivery of Gasdermin E mRNA Promotes Antitumor Immunity via Creatine-Elicited Type I Interferon Signaling in Monocytes. [Abstract]2025 Jun 4;13(6):939-956. PMID: 40168141
Creatine monohydrate purchased from MedChemExpress. Usage Cited in: Cancer Immunol Res. 2025 Jun 4;13(6):939-956. [Abstract]
Creatine (10, 100, and 1,000 µmol/L; 24 h) stimulates type I IFN induction via the cGAMP–cGAS–STING–IRF3 signaling axis. 2030-cGAMP was robustly induced in monocytes following Creatine treatment.
Creatine monohydrate purchased from MedChemExpress. Usage Cited in: Cancer Immunol Res. 2025 Jun 4;13(6):939-956. [Abstract]
Examination of cGAS-STING downstream signaling in monocytes by flow cytometry revealed activation of the STING-TBK1-IRF3 signaling axis following Creatine (10, 100, and 1,000 µmol/L; 24 h) treatment.
Creatine monohydrate purchased from MedChemExpress. Usage Cited in: Cancer Immunol Res. 2025 Jun 4;13(6):939-956. [Abstract]
Combination of LNP-Gsdme and Creatine (10.5 mg/mice; once daily; IT) synergistically suppresses tumor growth. Tumor growth curves, tumor images, and tumor weights of B16F10 and 4T1 tumor–bearing mice treated with LNP-Gsdme/GFP or combined with Creatine.
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Cell Rep
SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer. [Abstract]2025 Sep 1;44(9):116139. PMID: 40892544
Creatine monohydrate purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Sep 1;44(9):116139. [Abstract]
The syngeneic mouse MC38 CRC model was utilized to examine how Creatine (oral gavage; 50 mg/mL; 400 μL/time; 3 times per week) supplementation, with or without the addition of anti-PD-1 antibody, affected tumor growth and survival. Tumor growth, tumor weights, and survival curves were recorded for the MC38 model mice given the different therapies. Combination therapy significantly suppressed tumor growth and prolonged survival of MC38 tumor-bearing immunocompetent C57BL/6 J mice compared to either single-agent or control-treated groups.
Creatine monohydrate purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Sep 1;44(9):116139. [Abstract]
Tumor growth curve and tumor weights of DLD1 xenografts after indicated treatment.To ascertain whether Creatine (oral gavage; 50 mg/mL; 400 μL/time; 3 times per week) exhibits an inhibitory effect on tumor progression, a DLD-1 xenograft model was established, and Creatine was found to remarkably inhibit tumor development.
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Toxicol Appl Pharmacol
2022 Apr 15:441:115971. PMID: 35276125 -
Connect Tissue Res
Creatine promotes osteogenic differentiation of dental pulp stem cells via the AMPK-ULK1-autophagy axis. [Abstract]2025 Mar;66(2):73-86. PMID: 39930963
溶剤 & 溶解度
H2O : 16.67 mg/mL (111.77 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (393 KB)
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参考文献
[1]. Nouioua S, et al. Creatine deficiency syndrome. A treatable myopathy due to arginine-glycine amidinotransferase (AGAT) deficiency. Neuromuscul Disord. 2013 Aug;23(8):670-4. [Content Brief]
[2]. Gerber I, et al., Stimulatory effects of creatine on metabolic activity, differentiation and mineralization of primary osteoblast-like cells in monolayer and micromass cell cultures. Eur Cell Mater. 2005 Jul 15;10:8-22. [Content Brief]
[3]. Guidi C, et al., Differential effect of creatine on oxidatively-injured mitochondrial and nuclear DNA. Biochim Biophys Acta. 2008 Jan;1780(1):16-26. [Content Brief]
[4]. Cunha MP, et al., Antidepressant-like effect of creatine in mice involves dopaminergic activation. J Psychopharmacol. 2012 Nov;26(11):1489-501. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.7047 mL | 33.5233 mL | 67.0466 mL | 167.6165 mL |
| 5 mM | 1.3409 mL | 6.7047 mL | 13.4093 mL | 33.5233 mL | |
| 10 mM | 0.6705 mL | 3.3523 mL | 6.7047 mL | 16.7617 mL | |
| 15 mM | 0.4470 mL | 2.2349 mL | 4.4698 mL | 11.1744 mL | |
| 20 mM | 0.3352 mL | 1.6762 mL | 3.3523 mL | 8.3808 mL | |
| 25 mM | 0.2682 mL | 1.3409 mL | 2.6819 mL | 6.7047 mL | |
| 30 mM | 0.2235 mL | 1.1174 mL | 2.2349 mL | 5.5872 mL | |
| 40 mM | 0.1676 mL | 0.8381 mL | 1.6762 mL | 4.1904 mL | |
| 50 mM | 0.1341 mL | 0.6705 mL | 1.3409 mL | 3.3523 mL | |
| 60 mM | 0.1117 mL | 0.5587 mL | 1.1174 mL | 2.7936 mL | |
| 80 mM | 0.0838 mL | 0.4190 mL | 0.8381 mL | 2.0952 mL | |
| 100 mM | 0.0670 mL | 0.3352 mL | 0.6705 mL | 1.6762 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Creatine monohydrate 関連分類
HY-W017462 関連分類
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