製品番号: HY-N0059

D-Arabinose

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D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC₅₀ is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082).

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 98.0%
CAS 番号: 10323-20-3
分子式: C₅H₁₀O₅
分子量:150.13

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

D-Arabinose 構造式

CAS 番号: 10323-20-3

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
溶剤 & 溶解度
- 体外
- 体内
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

Human Endogenous Metabolite

PPAR-γ

Parasite アイソフォーム固有の製品をすべて表示 :

AMPK アイソフォーム固有の製品をすべて表示 :

PPAR アイソフォーム固有の製品をすべて表示 :

体外実験

D-Arabinose (40 μM; 24 h) activates the ACSS2-PPARγ/TFEB pathway in SH-SY5Y/BV2 cells and significantly upregulates CRTC1 protein level, BDNF mRNA level and AMPK phosphorylation level^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

SH-SY5Y (human neuroblastoma), BV2 (mouse microglia)
Concentration:

40 μM (WB/qPCR), 6 h (metabolic flux)
Incubation Time:

24 h
Result:

Increased CRTC1 protein (2.1±0.3-fold) and BDNF mRNA (1.8±0.2-fold) in both cell lines; PPARγ/TFEB proteins upregulated (1.7-fold), ACSS2 phosphorylation (S659) increased 2.5-fold.
Enhanced PPARγ/TFEB recruitment to CRTC1 promoter (2.3-fold for PPARγ, 1.9-fold for TFEB).
Increased glucose-derived pyruvate M+1 isotopomer and glutamate synthesis, while reducing ATP levels.

体内実験

D-Arabinose (2.5% or 5% drinking water; free drinking; 30 days) improves depressive-like behavior and reverses the downregulation of CRTC1 and BDNF expression in the hippocampus in the mouse chronic restraint stress (CRS) model^[1].
D-Arabinose (42 mM; 3 days) significantly inhibits the growth of C. elegans N2 strain (wild type)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 J male mice (6-8 weeks, CRS-induced depression model)^[1]
Dosage:

2.5% (w/v, drinking water), 5% (w/v, drinking water)
Administration:

Oral via drinking water ad libitum; 30 days (chronic treatment) or single gavage (3 h prior to testing)
Result:

Behavioral tests
Chronic treatment: 2.5% and 5% D-arabinose reduced immobility time in tail suspension test (TST, ↓35% and ↓41%, p<0.001) and forced swim test (FST, ↓38% and ↓45%, p<0.001), and increased sucrose preference (↑42% and ↑50%, p<0.01).
Single gavage (5%): Rapid antidepressant effect with TST immobility ↓28% at 3 h post-treatment.

Neurobiological changes
Hippocampal CRTC1 protein ↑2.1-fold (p<0.01) and BDNF mRNA ↑1.8-fold (p<0.05) in 2.5% group; dendritic spine density in DG region restored to control levels (↑65%, p<0.001).
Knockdown of hippocampal CRTC1/ACSS2/PPARγ/TFEB abolished D-arabinose’s antidepressant effects, confirming pathway dependency.

化学情報

CAS 番号 10323-20-3
性状 Solid
分子量 150.13
分子式 C₅H₁₀O₅
Color White to off-white
SMILES

O=C[C@H]([C@@H]([C@@H](CO)O)O)O
Structure Classification
- Saccharides
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
- Microorganisms
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (666.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.6609 mL

33.3045 mL

66.6089 mL

5 mM

1.3322 mL

6.6609 mL

13.3218 mL

10 mM

0.6661 mL

3.3304 mL

6.6609 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (16.65 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (16.65 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (16.65 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (278 KB)
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- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Guo Y, et al. D-arabinose acts as antidepressant by activating the ACSS2-PPARγ/TFEB axis and CRTC1 transcription. Pharmacol Res. 2024 Apr;202:107136. [Content Brief]

[2]. Sakoguchi H, et al. Growth inhibitory effect of D-arabinose against the nematode Caenorhabditis elegans: Discovery of a novel bioactive monosaccharide. Bioorg Med Chem Lett. 2016 Feb 1;26(3):726-729. [Content Brief]

[3]. LeBlanc DJ, et al. Metabolism of D-arabinose: a new pathway in Escherichia coli. J Bacteriol. 1971 Apr;106(1):90-6. [Content Brief]

[4]. An SJ, et al. Inhibitory effect of d-arabinose on oral bacteria biofilm formation on titanium discs. Anaerobe. 2022 Jun;75:102533. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	6.6609 mL	33.3045 mL	66.6089 mL	166.5223 mL
	5 mM	1.3322 mL	6.6609 mL	13.3218 mL	33.3045 mL
	10 mM	0.6661 mL	3.3304 mL	6.6609 mL	16.6522 mL
	15 mM	0.4441 mL	2.2203 mL	4.4406 mL	11.1015 mL
	20 mM	0.3330 mL	1.6652 mL	3.3304 mL	8.3261 mL
	25 mM	0.2664 mL	1.3322 mL	2.6644 mL	6.6609 mL
	30 mM	0.2220 mL	1.1101 mL	2.2203 mL	5.5507 mL
	40 mM	0.1665 mL	0.8326 mL	1.6652 mL	4.1631 mL
	50 mM	0.1332 mL	0.6661 mL	1.3322 mL	3.3304 mL
	60 mM	0.1110 mL	0.5551 mL	1.1101 mL	2.7754 mL
	80 mM	0.0833 mL	0.4163 mL	0.8326 mL	2.0815 mL
	100 mM	0.0666 mL	0.3330 mL	0.6661 mL	1.6652 mL

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D-Arabinose

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Parasite アイソフォーム固有の製品をすべて表示

AMPK アイソフォーム固有の製品をすべて表示

PPAR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

D-Arabinose 関連分類

HY-N0059 関連分類