Difopein
Difopein is a 14-3-3 protein inhibitor. Difopein acts as an apoptosis inducer, regulates apoptosis-related proteins, downregulates Bcl-2, upregulates Bax, activates caspase-9 and caspase-3, and induces nuclear fragmentation, membrane-enclosed apoptotic bodies and DNA ladder formation. Difopein serves as a tumor growth inhibitor, which inhibits the proliferation of glioma cells and induces their apoptosis in in vivo nude mouse models. Difopein is applicable to glioma-related research.
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- CAS 番号: 396834-58-5
- 分子式: C273H424N76O89S6
- 分子量:6387.13
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Caspase-9 |
Caspase-3 |
Bax |
Difopein (24-48 h) induces time-dependent apoptosis in human U251 and U87 glioma cells, causes time-dependent increases in both early and late apoptosis, and triggers apoptotic DNA fragmentation in U251 cells[1].
Difopein (24-48 h) alters the cell cycle distribution of U251 cells, causing time-dependent cell arrest at the G1 phase, while the proportions of cells in the S and G2 phases decrease; at 24 h and 48 h post-transfection, the proportions of G1-phase cells reach 73.9% and 84.8%, respectively[1].
Difopein (24-48 h) downregulates the anti-apoptotic protein Bcl-2 and upregulates the pro-apoptotic protein Bax at both mRNA and protein levels, and activates caspase-9 and caspase-3 in human U251 glioma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 396834-58-5
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分子量 6387.13
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分子式 C273H424N76O89S6
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配列
Ser-Ala-Asp-Gly-Ala-Pro-His-Cys-Val-Pro-Arg-Asp-Leu-Ser-Trp-Leu-Asp-Leu-Glu-Ala-Asn-Met-Cys-Leu-Pro-Gly-Ala-Ala-Gly-Leu-Asp-Ser-Ala-Asp-Gly-Ala-Pro-His-Cys-Val-Pro-Arg-Asp-Leu-Ser-Trp-Leu-Asp-Leu-Glu-Ala-Asn-Met-Cys-Leu-Pro-Gly-Ala-Ala-Gly-Leu-Glu
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シーケンスの短縮
SADGAPHCVPRDLSWLDLEANMCLPGAAGLDSADGAPHCVPRDLSWLDLEANMCLPGAAGLE
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Difopein 関連分類
HY-P1380 関連分類
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