DMTAP
Based on 1 Customer Validation
DMTAP is a cationic lipid. DMTAP inhibits PKC activity and reduces PKC-dependent cytokine secretion. DMTAP kills macrophages and monocyte-like cells, but not T lymphocytes. DMTAP induces CD80/CD86 in dendritic cells. DMTAP combined with DOPE (HY-112005)/DPPE inhibits nitric oxide, TNF-alpha, and Prostaglandin E2 (HY-101952). DMTAP can be used in research on inflammation and breast cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.70%
- CAS 番号: 197974-74-6
- 分子式: C34H68ClNO4
- 分子量:590.36
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
![Trimethyl[2,3-(dioleyloxy)propyl]ammonium chloride](https://file.medchemexpress.com/product_pic/hy-w127644.gif)
生物活性
製品説明
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PKC |
CD80 |
CD86 |
TNF-alpha |
体外実験
DMTAP alone is toxic to macrophages, and DOPE synergistically enhances DMTAP toxicity[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD1 (female)[5]
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Dosage:60 mg/kg
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Administration:i.p.; once; 2 h before Carrageenan injection
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Result:Significantly reduced footpad volume at 3 h.
Maximum inhibition occurred at 48 h.
The reduction persisted for at least 72 h.
化学情報
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CAS 番号 197974-74-6
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性状 Solid
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分子量 590.36
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分子式 C34H68ClNO4
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Color White to off-white
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SMILES
CCCCCCCCCCCCCC(OCC(OC(CCCCCCCCCCCCC)=O)C[N+](C)(C)C)=O.[Cl-]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外:
Ethanol : 20 mg/mL (33.88 mM; Need ultrasonic)
DMSO : 2 mg/mL (3.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / Ethanol | 1 mM | 1.6939 mL | 8.4694 mL | 16.9388 mL | 42.3470 mL |
| Ethanol | 5 mM | 0.3388 mL | 1.6939 mL | 3.3878 mL | 8.4694 mL |
| 10 mM | 0.1694 mL | 0.8469 mL | 1.6939 mL | 4.2347 mL | |
| 15 mM | 0.1129 mL | 0.5646 mL | 1.1293 mL | 2.8231 mL | |
| 20 mM | 0.0847 mL | 0.4235 mL | 0.8469 mL | 2.1174 mL | |
| 25 mM | 0.0678 mL | 0.3388 mL | 0.6776 mL | 1.6939 mL | |
| 30 mM | 0.0565 mL | 0.2823 mL | 0.5646 mL | 1.4116 mL |
DMTAP 関連分類
HY-112523A 関連分類
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