DP-15
Based on 1 Customer Validation
DP-15 is the degrader for GSPT1 and BRD4 with DC50s of 5.25 nM and 0.48 nM. DP-15 exhibits anti-proliferative activity of AML cells and NHL cells with an IC50 of nanomolar levels, arrests the cell cycle at G1 phase, and induces apoptosis in MOLM13. DP-15 exhibits anti-leukemia activity in MOLM-13 xenograft mouse models. (Pink: ligand for target protein JQ-1 carboxylic acid (HY-78695); Black: linker (HY-W262798); Blue: ligand for E3 ligase Cereblon Thalidomide-5-OH (HY-23095))
(Pink: BRD4 ligand (HY-78695); Blue: Cereblon ligand (HY-23095); Black: linker (HY-W262798)).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.06%
- CAS 番号: 3033837-71-4
- 分子式: C42H44ClN9O5S
- 分子量:822.37
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Apoptosis Compound Library
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生物活性
化学情報
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CAS 番号 3033837-71-4
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性状 Solid
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分子量 822.37
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分子式 C42H44ClN9O5S
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Color Light yellow to yellow
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SMILES
CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(N4CCN(CC4)CC5CCN(C6=CC=C(C(N(C7C(NC(CC7)=O)=O)C8=O)=O)C8=C6)CC5)=O)C9=NN=C(C)N29
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (121.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (254 KB)
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- Deutsch - DE (254 KB)
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- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2160 mL | 6.0800 mL | 12.1600 mL | 30.3999 mL |
| 5 mM | 0.2432 mL | 1.2160 mL | 2.4320 mL | 6.0800 mL | |
| 10 mM | 0.1216 mL | 0.6080 mL | 1.2160 mL | 3.0400 mL | |
| 15 mM | 0.0811 mL | 0.4053 mL | 0.8107 mL | 2.0267 mL | |
| 20 mM | 0.0608 mL | 0.3040 mL | 0.6080 mL | 1.5200 mL | |
| 25 mM | 0.0486 mL | 0.2432 mL | 0.4864 mL | 1.2160 mL | |
| 30 mM | 0.0405 mL | 0.2027 mL | 0.4053 mL | 1.0133 mL | |
| 40 mM | 0.0304 mL | 0.1520 mL | 0.3040 mL | 0.7600 mL | |
| 50 mM | 0.0243 mL | 0.1216 mL | 0.2432 mL | 0.6080 mL | |
| 60 mM | 0.0203 mL | 0.1013 mL | 0.2027 mL | 0.5067 mL | |
| 80 mM | 0.0152 mL | 0.0760 mL | 0.1520 mL | 0.3800 mL | |
| 100 mM | 0.0122 mL | 0.0608 mL | 0.1216 mL | 0.3040 mL |
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