ナラシン
Based on 2 publication(s) in Google Scholar
Narasin is a cationic ionophore antibiotic and coccidiostat agent. Narasin inhibits NF-κB signaling and induces tumor cells apoptosis. Narasin has antimicrobial, antiviral anticancer activity. Narasin inhibits tumor metastasis and growth of ERα‑positive breast cancer cells by inactivation of the TGF-β/SMAD3 and IL‑6/STAT3 signaling pathways.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 88.9%
- CAS 番号: 55134-13-9
- 分子式: C43H72O11
- 分子量:765.03
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Narasin
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生物活性
製品説明
IC50 & Target
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Coccidia |
体外実験
Narasin (1-25 ng/mL, 48 h) increases the percentage of phosphatidylserine exposing erythrocytes, cytosolic Ca2+ activity ([Ca2+]i) and the ceramide abundance at the erythrocyte surface[1].
Narasin (0-10 μM, 72 h) inhibits DENV2 infection with an IC50 value of 0.39 μM[2].
Narasin (0-10 μM, 72 h) significantly inhibits the cell viability of MCF-7, T47D and MDA-MB-231 cells, with respective IC50 values of 2.219, 3.562 and 11.76 µM[3].
Narasin (2.5-5 µM, 24 h) inhibits cell migration and invasion by suppressing EMT in ER+ BC cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7, T47D, MDA-MB-231
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Concentration:0-10 μM
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Incubation Time:72 h
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Result:Significantly reduced the viability of MCF-7 and T47D cells, with IC50 values of 2.219 and 3.562 µM, respectively.
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Cell Line:MCF-7 and T47D cells
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Concentration:2.5-5 µM
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Incubation Time:72 h
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Result:Significantly inhibited the migration of MCF-7 and T47D cells.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Xenograft mice model with MCF-7 cells
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Dosage:0.5 mg/kg or 1.5 mg/kg
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Administration:i.p., every 2 days for 50 consecutive days
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Result:Significantly decreased tumor volume and tumor weight in xenograft mice model with MCF-7 cells.
化学情報
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CAS 番号 55134-13-9
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性状 Solid
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分子量 765.03
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分子式 C43H72O11
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Color White to off-white
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SMILES
O[C@H]1[C@@]2(O[C@](C)([C@]3([H])O[C@H]([C@](CC)(O)CC3)C)CC2)O[C@@]4(O[C@]([C@@H](C)C[C@H]4C)([H])[C@@H](CC)C([C@@H](C)[C@@H](O)[C@@H]([C@]5([H])O[C@@]([C@@H](C)C[C@@H]5C)([H])[C@@H](CC)C(O)=O)C)=O)C=C1
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別名
Narasin
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Rep
Controlling mitochondrial membrane architecture via MIC60 determines viral replication to promote anti-viral immunity. [Abstract]2025 Jul 22;44(7):115922. PMID: 40628273 -
Talanta
Fluorescence-activated cell sorting-based efficient screening of monensin monoclonal antibodies and applications in lateral flow immunoassay. [Abstract]2025 Oct 1:293:128128. PMID: 40222095
溶剤 & 溶解度
体外:
DMSO : 12.5 mg/mL (16.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (279 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Ghada Bouguerra, et al. Stimulation of Eryptosis by Narasin. Cell Physiol Biochem. 2015;37(5):1807-16. [Content Brief]
[2]. Low JS, et al. Narasin, a novel antiviral compound that blocks dengue virus protein expression. Antivir Ther. 2011;16(8):1203-18. [Content Brief]
[3]. Chen J, et al. Narasin inhibits tumor metastasis and growth of ERα‑positive breast cancer cells by inactivation of the TGF‑β/SMAD3 and IL‑6/STAT3 signaling pathways. Mol Med Rep. 2020 Dec;22(6):5113-5124. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3071 mL | 6.5357 mL | 13.0714 mL | 32.6785 mL |
| 5 mM | 0.2614 mL | 1.3071 mL | 2.6143 mL | 6.5357 mL | |
| 10 mM | 0.1307 mL | 0.6536 mL | 1.3071 mL | 3.2678 mL | |
| 15 mM | 0.0871 mL | 0.4357 mL | 0.8714 mL | 2.1786 mL |
Narasin 関連分類
HY-121410 関連分類
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