PRO-HD2
PRO-HD2 is a HDAC6 PROTAC degrader. PRO-HD2 exerts antiproliferative activity in leukemia cells. PRO-HD2 can be used for leukemia research.
(Pink: HDAC6 ligand (HY-175627); Blue: Cereblon ligand (HY-41547); Black: linker).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3126555-89-0
- 分子式: C38H39N5O5S
- 分子量:677.81
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
PROTACs アイソフォーム固有の製品をすべて表示
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生物活性
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HDAC6 |
Cereblon |
PRO-HD2 (500 nM-5 μM; 24 h) efficiently degrades HDAC6 in A549 cells. After 24 h of incubation, almost complete depletion of HDAC6 is observed at concentrations ≥ 500 nM[1].
PRO-HD2 (0.5-1 μM; 12-48 h) efficiently degrades HDAC6 in MCF-7, HCT-116, A549 and Jurkat cells[1].
PRO-HD2 (48 h) inhibits the proliferation of Jurkat cells, with an IC50 of 2.62 μM after 48 h of incubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells (adenocarcinomic human alveolar basal epithelial cells)
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Concentration:500 nM, 1 μM, 5 μM
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Incubation Time:24 h
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Result:Nearly completely depleted HDAC6 protein.
Exhibited higher HDAC6 degradation efficiency compared to PRO-HD1 and PRO-HD3.
化学情報
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CAS 番号 3126555-89-0
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分子量 677.81
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分子式 C38H39N5O5S
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SMILES
S=C1N(CC2=CC=C(C3=CC=C(CNCCCCCCNC4=CC=CC(C(N5C6CCC(NC6=O)=O)=O)=C4C5=O)C=C3)C=C2)C=CC=C1O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PRO-HD2 関連分類
HY-155397 関連分類
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