Questiomycin A
Based on 1 Customer Validation
Questiomycin A (Phx-3) is a GRP78 (cytoprotective endoplasmic reticulum chaperone) degrader and enhances the anticancer activity of Sorafenib. Questiomycin A is also an antimicrobial/antibiotic that can be obtained from the metabolite of Pseudomonas chlororaphis HT66. Questiomycin A can be used in research on biological control of cancer and plant diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.20%
- CAS 番号: 1916-59-2
- 分子式: C12H8N2O2
- 分子量:212.20
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
Antibacterial Compound Library
HY-L049
-
Endoplasmic Reticulum Stress Compound Library
HY-L054
-
Cytoskeleton Compound Library
HY-L060
-
Antibiotics Library
HY-L067
-
Microbial Metabolite Library
HY-L084
-
Anti-Cancer Natural Product Library
HY-L107
-
Human Metabolite Library
HY-L123
-
Cuproptosis Compound Library
HY-L133
-
Metabolic Enzyme Compound Library
HY-L146
-
Highly Selective Inhibitors Library
HY-L158
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Natural Product Library Plus
HY-L021P
-
Bioactive Compound Library
HY-L001
-
RO5 Drug-like Natural Product Library
HY-L200
-
High-Throughput Bioactive Compound Library
HY-L205
-
High-Throughput Natural Product Library
HY-L206
-
Mass Spectrometry Human Metabolite Library
HY-L215
-
Amino Acid Metabolite Compound Library
HY-L227
-
Chinese Baijiu Compound Library
HY-L241
-
Natural Product Diversity Scaffold Library
HY-L245
-
Fungal-Sourced Compound Library
HY-L253
-
Mass Spectrometry Natural Product Library
HY-L262
-
Natural Product and Natural Product-Like Compound Library
HY-L021M
-
Anti-Infection Compound Library
HY-L002
-
Cell Cycle/DNA Damage Compound Library
HY-L004
-
Metabolism/Protease Compound Library
HY-L012
-
Natural Product Library
HY-L021
-
Anti-Cancer Compound Library
HY-L025
-
Anti-Aging Compound Library
HY-L034
Antibiotic アイソフォーム固有の製品をすべて表示
More
生物活性
|
Grp78 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | IC50 |
2 μM
Compound: 1
|
Compound concentration required to reduce the cell proliferation of human acute T-lymphoblastic leukemia CCRF-CEM cells by 50%, using MTT method
Compound concentration required to reduce the cell proliferation of human acute T-lymphoblastic leukemia CCRF-CEM cells by 50%, using MTT method
|
[PMID: 12431048] |
| CCRF-SB | IC50 |
1 μM
Compound: 1
|
Compound concentration required to reduce the cell proliferation of human acute B-lymphoblastic leukemia CCRF-SB cells by 50%, using MTT method
Compound concentration required to reduce the cell proliferation of human acute B-lymphoblastic leukemia CCRF-SB cells by 50%, using MTT method
|
[PMID: 12431048] |
| HeLa | IC50 |
2.7 μM
Compound: 1
|
Compound concentration required to reduce the cell proliferation of cervix carcinoma Hela cells by 50%, using MTT method
Compound concentration required to reduce the cell proliferation of cervix carcinoma Hela cells by 50%, using MTT method
|
[PMID: 12431048] |
| HEp-2 | IC50 |
1.8 μM
Compound: 1
|
Compound concentration required to reduce the cell proliferation of larynx carcinoma cells by 50%, using MTT method
Compound concentration required to reduce the cell proliferation of larynx carcinoma cells by 50%, using MTT method
|
[PMID: 12431048] |
Questiomycin A (3 µM; 24 h) induces cell death and downregulates GRP78 protein expression in HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HepG2 cells
-
Concentration:3 µM
-
Incubation Time:24 h
-
Result:Suppressed more than 50% of the GRP78 expression and induced cell death.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Nude mice (HepG2 cells xenograft model)[1].
-
Dosage:10 mg/kg
-
Administration:Intraperitoneal injection; once a day; 8 days.
-
Result:Stimulated Sorafenib-dependent antitumor activity.
化学情報
-
CAS 番号 1916-59-2
-
性状 Solid
-
分子量 212.20
-
分子式 C12H8N2O2
-
Color Brown to black
-
SMILES
O=C1C(N)=CC2=NC3=C(C=CC=C3)OC2=C1
-
別名
Phx-3
-
Structure Classification
-
Initial Source
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 12.5 mg/mL (58.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (274 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Machihara K, et al. Questiomycin A stimulates sorafenib-induced cell death via suppression of glucose-regulated protein 78. Biochem Biophys Res Commun. 2017 Oct 7;492(1):33-40. [Content Brief]
[2]. Guo S, et al. Production of Antibacterial Questiomycin A in Metabolically Engineered Pseudomonas chlororaphis HT66. J Agric Food Chem. 2022 Jun 29;70(25):7742-7750. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7125 mL | 23.5627 mL | 47.1254 mL | 117.8134 mL |
| 5 mM | 0.9425 mL | 4.7125 mL | 9.4251 mL | 23.5627 mL | |
| 10 mM | 0.4713 mL | 2.3563 mL | 4.7125 mL | 11.7813 mL | |
| 15 mM | 0.3142 mL | 1.5708 mL | 3.1417 mL | 7.8542 mL | |
| 20 mM | 0.2356 mL | 1.1781 mL | 2.3563 mL | 5.8907 mL | |
| 25 mM | 0.1885 mL | 0.9425 mL | 1.8850 mL | 4.7125 mL | |
| 30 mM | 0.1571 mL | 0.7854 mL | 1.5708 mL | 3.9271 mL | |
| 40 mM | 0.1178 mL | 0.5891 mL | 1.1781 mL | 2.9453 mL | |
| 50 mM | 0.0943 mL | 0.4713 mL | 0.9425 mL | 2.3563 mL |
Questiomycin A 関連分類
HY-N8439 関連分類
Powered by Bioz