製品番号: HY-N1195

Sugiol

Name: Sugiol
Brand: MedChemExpress
SKU: HY-N1195
Price: 380.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(別名: (+)-Sugiol; 10-Deoxoxanthoperol)

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Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages.

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純度 : 99.88%
CAS 番号: 511-05-7
分子式: C₂₀H₂₈O₂
分子量:300.44

保管条件:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Sugiol 構造式

CAS 番号: 511-05-7

容量

価格（税別）

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数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]

ERK1

ERK2

p38 MAPK

JNK1

JNK2

IL-1β

p38 MAPK アイソフォーム固有の製品をすべて表示 :

ERK アイソフォーム固有の製品をすべて表示 :

JNK アイソフォーム固有の製品をすべて表示 :

Interleukin Related アイソフォーム固有の製品をすべて表示 :

TNF Receptor アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	<50 μg/mL Compound: 4	Inhibitory activity against human A549 lung tumor cell proliferation Inhibitory activity against human A549 lung tumor cell proliferation	[PMID: 15808460]
A549	GI₅₀	79.8 μM Compound: 13	Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
A549	IC₅₀	>10 μM Compound: 17	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 33978415]
BEAS-2B	IC₅₀	>10 μM Compound: 17	Cytotoxicity against human BEAS2B cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human BEAS2B cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 33978415]
BXPC-3	GI₅₀	36.08 μM Compound: 13	Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
HCT-116	GI₅₀	<50 μg/mL Compound: 4	Growth inhibitory activity against human HCT116 colon tumor cell line Growth inhibitory activity against human HCT116 colon tumor cell line	[PMID: 15808460]
HL-60	GI₅₀	68.64 μM Compound: 13	Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
HL-60	IC₅₀	>10 μM Compound: 17	Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 33978415]
K562	IC₅₀	6.7 μM Compound: Sugiol	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 30684866]
MCF7	IC₅₀	>10 μM Compound: 17	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 33978415]
MDA-MB-231	GI₅₀	<50 μg/mL Compound: 4	Growth inhibitory activity against human MDA-MB-231 breast tumor cell line Growth inhibitory activity against human MDA-MB-231 breast tumor cell line	[PMID: 15808460]
MIA PaCa-2	IC₅₀	17.9 μM Compound: 10	Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay	[PMID: 21775156]
MRC5	GI₅₀	>100 μM Compound: 13	Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
NCI-H23	GI₅₀	<50 μg/mL Compound: 4	Growth inhibitory activity against human NCI-H23 lung tumor cell line Growth inhibitory activity against human NCI-H23 lung tumor cell line	[PMID: 15808460]
PANC-1	GI₅₀	87.94 μM Compound: 13	Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
PC-3	GI₅₀	>100 μM Compound: 13	Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
SMMC-7721	IC₅₀	>10 μM Compound: 17	Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 33978415]
SW480	IC₅₀	>10 μM Compound: 17	Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 33978415]
SW-620	GI₅₀	<50 μg/mL Compound: 4	Growth inhibitory activity against human SW620 colon tumor cell line Growth inhibitory activity against human SW620 colon tumor cell line	[PMID: 15808460]
Vero	IC₅₀	24.6 μM Compound: 2	Trypanocidal activity against intracellular amastigote form of Trypanosoma cruzi IRHOD/CO/2008/SN3 in african green monkey Vero cells Trypanocidal activity against intracellular amastigote form of Trypanosoma cruzi IRHOD/CO/2008/SN3 in african green monkey Vero cells	[PMID: 25462275]
Vero	IC₅₀	45.4 μM Compound: 2	Cytotoxicity against african green monkey Vero cells after 72 hrs Cytotoxicity against african green monkey Vero cells after 72 hrs	[PMID: 25462275]

体外実験

Sugiol (5-30 μM; 30 min) inhibits TNF-α and proIL-1β/IL-1β protein production in J774A.1 cells^[1].
Sugiol (5-30 μM; 30 min) inhibits MAPK activation, suppresses ERK1/2, JUNK1/2, and p38 phosphorylation in LPS-induced J774A.1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

J774A.1 macrophages cells stimulated with LPS
Concentration:

5 μM, 10 μM, 20 μM, and 30 μM
Incubation Time:

30 min
Result:

Completely inhibited ERK1/2 phosphorylation at 30 μM, and effectively inhibited JNK1/2 and p38 phosphorylation.

Related Protocols :

化学情報

CAS 番号 511-05-7
性状 Solid
分子量 300.44
分子式 C₂₀H₂₈O₂
Color White to off-white
SMILES

O=C1C2=C(C=C(O)C(C(C)C)=C2)[C@@]3(C)CCCC(C)(C)[C@]3([H])C1
別名

(+)-Sugiol; 10-Deoxoxanthoperol
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Chao KP, et al. Anti-inflammatory activity of sugiol, a diterpene isolated from Calocedrus formosana bark. Planta Med. 2005 Apr;71(4):300-5. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Sugiol

p38 MAPK アイソフォーム固有の製品をすべて表示

ERK アイソフォーム固有の製品をすべて表示

JNK アイソフォーム固有の製品をすべて表示

Interleukin Related アイソフォーム固有の製品をすべて表示

TNF Receptor アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC₅₀ & Target

Cellular Effect

体外実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Bioz

Keywords

最近チェックした製品

Sugiol

p38 MAPK アイソフォーム固有の製品をすべて表示

ERK アイソフォーム固有の製品をすべて表示

JNK アイソフォーム固有の製品をすべて表示

Interleukin Related アイソフォーム固有の製品をすべて表示

TNF Receptor アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

Cellular Effect

体外実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Sugiol 関連分類

HY-N1195 関連分類

Bioz

Keywords

最近チェックした製品

IC₅₀ & Target