TLR7 - toll like receptor 7 Gene

Also Known as IMD74; SLEB17; TLR7-like

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51284

About TLR7

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:12,867,072-12,890,361 (from NCBI)

This gene has 2 transcripts (splice variants), 197 orthologues, 22 paralogues and is associated with 2 phenotypes. Broad expression in placenta (RPKM 3.3), appendix (RPKM 3.0) and 23 other tissues.

Summary

The protein encoded by this gene is a member of the Toll-like Receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The human TLR family comprises 11 members. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. For the recognition of structural components in foreign Microorganisms, the various TLRs exhibit different patterns of expression as well; in this way for example, TLR-3, -7, and -8 are essential in the recognition of single-stranded RNA viruses. TLR7 senses single-stranded RNA oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells. This gene is predominantly expressed in lung, placenta, and spleen, and is phylogenetically related and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Aug 2020]

TLR7 Products (2)

mRNA	Protein	Name
NG_001066.3
NM_016562.4	NP_057646.1	toll-like receptor 7 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	16111635	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	33432245	GOA
enables single-stranded RNA binding	IMP IMP: Inferred from mutant phenotype	35477763	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in I-kappaB phosphorylation	IDA IDA: Inferred from direct assay	19740627	GOA
involved in canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	35477763	GOA
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19593445	GOA
involved in defense response to virus	IEP IEP: Inferred from expression pattern	32634389	GOA
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	16188996	GOA
involved in innate immune response	IMP IMP: Inferred from mutant phenotype	35477763	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	12032557	GOA
involved in positive regulation of chemokine production	IDA IDA: Inferred from direct assay	19740627	GOA
involved in positive regulation of interferon-alpha production	IDA IDA: Inferred from direct assay	16286015	GOA
involved in positive regulation of interferon-beta production	IDA IDA: Inferred from direct assay	16286015	GOA
involved in positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	19740627	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	16188996	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	19740627	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	16286015	GOA
involved in response to cGMP	IMP IMP: Inferred from mutant phenotype	35477763	GOA
involved in toll-like receptor 7 signaling pathway	IDA IDA: Inferred from direct assay	12032557	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19740627	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19740627	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLR7 Protein Structure

LRR_8

LRR_1

LRR_8

LRR_1

TIR

0
200
400
600
800
1000
1049 a.a.

Protein Preferred Names	Protein Names
toll-like receptor 7	toll-like receptor 7-like

Recombinant TLR7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79404	TLR7 Protein, Human (His, Myc)	Q9NYK1 (H861-V1049)	≥ 90%, as determined by reducing SDS-PAGE.

TLR7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82769	Toll-Like Receptor 7 Antibody (YA2514)	WB, IHC-P	Human
HY-P84838	Toll-Like Receptor 7 Antibody (YA4535)	ICC/IF, FC, ELISA	Human
HY-P84838A	Toll-Like Receptor 7 Antibody (YA4535)(PBS only)	ICC/IF, FC, ELISA	Human
HY-P85638	Toll-like Receptor 7 Antibody (YA5330)	WB	Transfected
HY-P86689	Toll-Like Receptor 7 Antibody (YA6381)	FC, WB	Human
HY-P86689A	Toll-Like Receptor 7 Antibody (YA6381)(PBS only)	FC, WB	Human

Related Diseases

Diseases	Alias
Micronodular Basal Cell Carcinoma	Skin Micronodular Basal Cell Carcinoma Basal Cell Carcinoma, Micronodular
Ebola Hemorrhagic Fever	Ebola Virus Disease Viral Hemorrhagic Fever Hemorrhagic Fever, Ebola Ehf Ebola Fever Ebola Hemorrhagic Fevers, Viral Ebola Haemorrhagic Fever Ebod - [Ebola Disease] Evd - [Ebola Virus Disease] Ebola Virus Haemorrhagic Fever Vhf - [Viral Haemorrhagic Fever] Nos Viral Haemorrhagic Fever, Not Otherwise Specified
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Actinic Keratosis	Solar Keratosis Actinic Keratosis Senile Hyperkeratosis Sk - Solar Keratosis Keratosis, Actinic Seborrheic Keratosis Ak - [Actinic Keratosis] Sk - [Solar Keratosis]
Hand, Foot And Mouth Disease	Vesicular Stomatitis And Exanthem
Parasitic Protozoa Infectious Disease	Protozoan Infections Mastigophora Infectious Disease Sarcomastigophora Infectious Disease
Systemic Lupus Erythematosus 17	SLEB17
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Encephalopathy With Basal Ganglia Calcification Aicardi-Goutières Syndrome Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Avian Influenza	Bird Flu Influenza In Birds Avian Flu
Cutaneous Lupus Erythematosus	Lupus Erythematosus, Cutaneous Lupus Erythematosus Cutaneous
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Pre-Malignant Neoplasm
Common Wart	Verruca Vulgaris Viral Warts Nos Filiform Warts Digitate Warts
Autoimmune Disease Of Skin And Connective Tissue
Immune-Complex Glomerulonephritis	Immune Complex Glomerulonephritis
Skin Carcinoma	Skin Cancer Carcinoma Of Skin Ca - Skin Cancer Cancer Of Skin Malignant Neoplasm Of Skin Melanoma And Non-Melanoma Skin Cancer Skin Cancers Cancer, Skin
Anaerobic Pneumonia	Pneumonia Due To Anaerobes
West Nile Encephalitis	West-Nile Encephalitis West Nile Fever West Nile Fever Encephalitis West Nile Fever With Encephalitis West-Nile Fever Encephalitis, West Nile Fever
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Autoimmune Disease Of Exocrine System
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Human Immunodeficiency Virus Infectious Disease	Hiv Infections
Immunodeficiency 74, Covid19-Related, X-Linked	Respiratory Insufficiency Due To Sars-Cov-2 Viral Infection IMD74 Tlr7 Deficiency
Severe Covid-19
Respiratory Failure	Acute Respiratory Failure Chronic Respiratory Failure Respiratory Insufficiency Acute-On-Chronic Respiratory Failure Acute And Chronic Respiratory Failure Respiratory Insufficiency/Failure Chronic Respiratory Disease Respiratory Disease Pulmonary Valve Insufficiency Chronic Disease Of Respiratory System Respiration Disorders Respiratory Tract Diseases Lung Failure Nos Pulmonary Failure Arf - [Acute Respiratory Failure] Acute Respiratory Insufficiency Acute Pulmonary Insufficiency Acute Respiration Failure Chronic Respiration Failure
Primary Bacterial Infectious Disease
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Lyme Disease	Lyme Borreliosis Lyme Neuroborreliosis Borreliosis Borrelia Burgdorferi Infection Neuroborreliosis Bannwarth Syndrome Bannworth'S Syndrome Neurological Lyme Disease B. Burgdorferi Infection Borreliosis, Lyme Infection By Borrelia Burgdorferi Infection Due To Borrelia Burgdorferi Sensu Lato Lym Borrelia Infections
Measles	Rubeola Morbilli Measles Nos Koplik Spots
Superficial Basal Cell Carcinoma	Multifocal Superficial Basal Cell Carcinoma Multicentric Basal Cell Carcinoma Superficial Multicentric Basal-Cell Carcinoma
Herpangina	Vesicular Pharyngitis
Bronchiolitis
Genital Herpes	Herpes Genitalis Genital Herpes Simplex Venereal Herpes Virus-Genital Herpes
Covid-19	2019 Novel Coronavirus 2019-Ncov Infection Covid19 Sars-Cov-2 Infection Wuhan Coronavirus Infection Wuhan Seafood Market Pneumonia Virus Infection
Integumentary System Disease
Lymphadenitis	Acute Lymphadenitis Chronic Lymphadenitis Chronic Adenitis Acute Adenitis Adenitis Inflammation Of Lymph Node Adenitis Nos Inflammation Of Gland Lymphatic Gland Inflammation Lymph Gland Inflammation Polyadenitis Chronic Adenitis Of Any Lymph Node Except Mesenteric Chronic Lymphadenitis Except Mesenteric Chronic Non-Specific Lymphadenitis
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
T Cell Deficiency	T Cell Immunodeficiency T Lymphocyte Deficiency T Lymphocyte Immunodeficiency T-Lymphocyte Deficiency
Borst-Jadassohn Intraepidermal Carcinoma	Intraepidermal Epithelioma Of Jadassohn Bowen'S Disease, Clonal
Autoimmune Disease Of Musculoskeletal System
Heart Block, Congenital	Congenital Heart Block Heart Block Congenital Congenital Atrioventricular Block
Mouth Disease	Mouth Diseases Mouth Disorders
Swine Influenza	Influenza Due To Influenza A Virus Subtype H1n1
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Chilblain Lupus 1	Chilblain Lupus CHBL1 Chilblain Lupus Erythematosus Chle Hutchinson Lupus Chilblain Lupus, Type 1
Chromoblastomycosis	Chromomycosis Mossy Foot Disease Verrucous Dermatitis Fonseca Disease Pedroso Disease Drechslera Hawaiiensis Drechslera Infection
Coronavirus Infectious Disease
Subcutaneous Mycosis	Subcutaneous Fungal Disease
Potocki-Shaffer Syndrome	Proximal 11p Deletion Syndrome Chromosome 11p11.2 Deletion Syndrome Pss 11p11.2 Deletion P11pds Defect11 Syndrome Deletion Of Chromosome 11p11.2 POSHS
Disease By Infectious Agent	Infectious Disease Infectious Diseases
X-Linked Immunodeficiency 74	Immunodeficiency 74, Covid-19-Related, X-Linked Imd74 Respiratory Insufficiency Due To Sars-Cov-2 Viral Infection Tlr7 Deficiency X-Linked Immunodeficiency 74,Covid-19-Related
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Viral Infectious Disease	Arbovirus Infections Viral Disease Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Anogenital Venereal Wart	Genital Warts Condylomata Acuminata Anogenital Warts Condyloma Acuminatum Anogenital Human Papilloma Virus Infectious Disease Genital Wart Virus Infectious Disease Venereal Wart Venereal Warts Verrucae Anogenitales Verrucae Genitales
Chikungunya	Chikungunya Fever Arbovirus A Chikungunya Type Chik Chikv Infection Ck Chikungunya Virus Infection Chikungunya Haemorrhagic Fever Chikungunya Viral Disease Chikungunya Mosquito-Borne Viral Fever

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0180	Imiquimod	Agonist	99.97%	Unkown
HY-B1370	Hydroxychloroquine sulfate	Inhibitor	99.99%	Yes
HY-B0180A	Imiquimod hydrochloride	Agonist	99.77%	Yes
HY-B0180B	Imiquimod maleate	Agonist	99.92%	Yes
HY-B1370B	(R)-Hydroxychloroquine	Inhibitor	/	Unkown
HY-B1370A	(S)-Hydroxychloroquine	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Phase
HY-165632	Creatine ethyl ester	Activator	/	Phase 4
HY-134581A	Enpatoran hydrochloride	Inhibitor	99.42%	Phase 3
HY-W008634	Bropirimine	Agonist	99.94%	Phase 3
HY-13740	Resiquimod	Agonist	99.95%	Phase 2
HY-15601	Vesatolimod	Agonist	99.90%	Phase 2
HY-13740G	Resiquimod (GMP)	Agonist	/	Phase 2
HY-108472	Loxoribine	Agonist	99.94%	Phase 2
HY-100176	PF-4878691	Agonist	99.89%	Phase 2
HY-111269	AZD8848	Agonist	99.14%	Phase 2
HY-118250	GSK2245035	Agonist	99.79%	Phase 2
HY-139575	Guretolimod	Agonist	/	Phase 2
HY-177617A	Bazlitoran sodium	Agonist	95.30%	Phase 2
HY-177617	Bazlitoran	Agonist	95.30%	Phase 2
HY-13655A	Isatoribine	Agonist	/	Phase 2
HY-109104	Telratolimod	Agonist	98.85%	Phase 1
HY-111786	LHC-165	Agonist	98.0%	Phase 1
HY-178166	ETI41	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (93)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134581	Enpatoran	Inhibitor	99.87%	Unkown
HY-N0201	Atractylenolide I	Antagonist	99.98%	Unkown
HY-124603	AT791	Inhibitor	98.77%	Unkown
HY-128799	CL097	Agonist	99.90%	Unkown
HY-160229	ssRNA40 sodium	Activator	98.34%	Unkown
HY-12756	E6446	Antagonist	98.78%	Unkown
HY-12756A	E6446 dihydrochloride	Antagonist	99.29%	Unkown
HY-103697	Gardiquimod		99.91%	Unkown
HY-103698	TLR7/8 agonist 1	Agonist	98.42%	Unkown
HY-139323	TLR7/8-IN-1	Inhibitor	99.92%	Unkown
HY-135905	CL264	Inhibitor	98.63%	Unkown
HY-103698A	TLR7/8 agonist 1 dihydrochloride	Agonist	99.70%	Unkown
HY-110120	DSR-6434	Agonist	99.32%	Unkown
HY-128799A	CL097 hydrochloride	Agonist	99.96%	Unkown
HY-111582	BBIQ	Agonist	99.81%	Unkown
HY-B1370R	Hydroxychloroquine sulfate (Standard)	Inhibitor	99.96%	Unkown
HY-160227A	ORN 06 sodium	Activator	95.05%	Unkown
HY-130797	TLR7/8 agonist 3	Agonist	99.96%	Unkown
HY-153879	C12-TLRa	Ligand	99.71%	Unkown
HY-111358	TLR7 agonist 1	Agonist	98.19%	Unkown
HY-159102	PVP-037.2	Agonist	99.18%	Unkown
HY-115400	1V209	Agonist	99.67%	Unkown
HY-117602	TLR7 agonist 3	Agonist	99.90%	Unkown
HY-156174	E104	Inhibitor	99.38%	Unkown
HY-13740S	Resiquimod-d5	Agonist	98.33%	Unkown
HY-150736	ODN 20844	Inhibitor	96.14%	Unkown
HY-139017	TLR7/8 agonist 4	Agonist	99.18%	Unkown
HY-138139B	AXC-715 trihydrochloride	Agonist	99.76%	Unkown
HY-131945	CU-115	Antagonist	99.63%	Unkown
HY-103697A	Gardiquimod diTFA		99.0%	Unkown
HY-138139A	AXC-715 hydrochloride	Agonist	99.89%	Unkown
HY-110207	SM-324405	Agonist	98.52%	Unkown
HY-145885	TLR7/8 agonist 6	Agonist	98.93%	Unkown
HY-156693A	MTvkPABC-P5 TFA	Agonist	98.78%	Unkown
HY-176774	L07-2	Agonist	99.83%	Unkown
HY-157793	SMU-L11	Agonist	99.64%	Unkown
HY-145960A	MC-Val-Cit-PAB-Amide-TLR7 agonist 4 formic	Agonist	97.70%	Unkown
HY-158694A	TLR7 agonist 20 hydrochloride	Agonist	99.86%	Unkown
HY-164485	INI-4001	Activator	/	Unkown
HY-145961	TLR7 agonist 4	Agonist	98.87%	Unkown
HY-179474	TSI-13-57	Inhibitor	98.73%	Unkown
HY-178037	TLR9 antagonist 1	Antagonist	/	Unkown
HY-153071	TLR7 agonist 6	Agonist	98.08%	Unkown
HY-145960	MC-Val-Cit-PAB-Amide-TLR7 agonist 4	Agonist	99.39%	Unkown
HY-150158	TMX-201		≥95.0%	Unkown
HY-150744	ODN 24888	Inhibitor	/	Unkown
HY-10018	Toll-like receptor modulator	Modulator	99.36%	Unkown
HY-153543	TLR7/8 agonist 8	Agonist	98.69%	Unkown
HY-101589	Sotirimod	Agonist	99.90%	Unkown
HY-139017A	TLR7/8 agonist 4 TFA	Agonist	/	Unkown
HY-141454A	TLR8 agonist 2 hydrochloride	Agonist	/	Unkown
HY-141454	TLR8 agonist 2	Agonist	/	Unkown
HY-147215	UC-1V150	Agonist	/	Unkown
HY-163670	TLR7 agonist 21	Inhibitor	/	Unkown
HY-175421	ArMan	Activator	/	Unkown
HY-156175	TLR7 agonist 14	Agonist	/	Unkown
HY-168159	TLR7 agonist 27	Agonist	/	Unkown
HY-153544	TLR7/8 agonist 9	Inhibitor	/	Unkown
HY-121496	3M-011	Agonist	/	Unkown
HY-179007	TLR7 agonist 31	Agonist	/	Unkown
HY-153070	TLR7 agonist 5	Agonist	/	Unkown
HY-183079	ENDO12	Inhibitor	/	Unkown
HY-153073	TLR7 agonist 8	Agonist	/	Unkown
HY-159916	AYK004	Agonist	/	Unkown
HY-159914	AYK004-B1	Agonist	/	Unkown
HY-168157	TLR7 agonist 26	Agonist	/	Unkown
HY-163398	TLR7-IN-1	Inhibitor	/	Unkown
HY-162845	TLR7/8 agonist 11	Agonist	/	Unkown
HY-176553	KBD4466	Inhibitor	/	Unkown
HY-184473	NOD1/TLR7 agonist-1	Agonist	/	Unkown
HY-175782	SMU-R39	Antagonist	/	Unkown
HY-160227	ORN 06	Activator	/	Unkown
HY-181796	TLR7 antagonist-1	Antagonist	/	Unkown
HY-153072	TLR7 agonist 7	Agonist	/	Unkown
HY-169017	MTT5	Agonist	98.49%	Unkown
HY-162115	TLR7 agonist 17	Agonist	/	Unkown
HY-169057	BI1543673	Inhibitor	/	Unkown
HY-178169	ETI60	Inhibitor	99.51%	Unkown
HY-173070	TLR7 agonist 29	Agonist	/	Unkown
HY-152726	TLR7 agonist 9	Agonist	/	Unkown
HY-117686	AZ12441970	Agonist	/	Unkown
HY-179336	TLR7/8 agonist 14	Agonist	/	Unkown
HY-179047	SMU-L11-R	Agonist	/	Unkown
HY-170899	TLR7 agonist 28	Agonist	/	Unkown
HY-162725	TLR7 agonist 24	Agonist	/	Unkown
HY-179209	TLR9-IN-2	Inhibitor	/	Unkown
HY-145886	TLR7/8 antagonist 1	Antagonist	/	Unkown
HY-158694	TLR7 agonist 20	Agonist	/	Unkown
HY-159919	UM-3006	Agonist	/	Unkown
HY-131920	Poly(U)	Agonist	/	Unkown
HY-111582G	BBIQ (GMP)	Agonist	/	Unkown
HY-177300	TLR7/8 agonist 13	Agonist	/	Unkown
HY-183400	BIM-46174	Inhibitor	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991956	ABB071	Inhibitor	/	Unkown
HY-P992348	DS-7011a	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TLR7	MGD	MGI:2176882
Bos taurus	TLR7	VGNC	VGNC:52836
Rattus norvegicus	TLR7	RGD	RGD:1563357
Canis familiaris	TLR7	VGNC	VGNC:54607
Macaca mulatta	TLR7	VGNC	VGNC:78390
Others	TLR7	NCBI