OptoDArG

OptoDArG (20 m%; 50 ms) UV-driven trans-to-cis photoisomerization increases bilayer capacitance by +4.54 pF and generates depolarizing optocapacitive currents, whereas blue-driven cis-to-trans isomerization decreases capacitance by −3.57 pF and generates oppositely directed currents in PLBs^[1].
OptoDArG (60 µM; 1 h) in HEK293 NaV1.3 cells, UV light generates optocapacitive depolarization that triggers APs with 33.3% success, while blue light triggers Gd³⁺-sensitive mechanosensitive depolarizing currents and APs^[1].
OptoDArG (30 μM; 30 s) is a light-controlled DAG photoswitch whose cis isomer rapidly and reversibly activates TRPC3 conductance in HEK293 cells expressing TRPC3^[2].
OptoDArG (30 μM) facilitates photoactivation with a lower light-intensity threshold and reduced activation sigmoidicity (mean n = 2.9 at maximum light intensity) in HEK293 cells expressing TRPC3-G652A^[2].
OptoDArG photoactivation sensitivity is reduced in HEK293 cells expressing TRPC6-G709A^[2].
OptoDArG is a highly efficient photochromic ligand that facilitates activation of the TRPC3 G652A mutant in HEK293 cells via a lipid-sensing site near the selectivity filter using 365/430 nm light^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.