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Sodium butyrate

(Synonyms: Butanoic acid sodium; Butyric acid sodium)
28 Cited Publications
고객리뷰

Based on 28 publication(s) in Google Scholar

Sodium butyrate ((Butanoic acid; Butyric acid) sodium) is an orally active HDAC inhibitor. Sodium butyrate induces hyperacetylation of core histones and affects phosphorylation of H1/H2A, thereby altering chromatin structure and regulating gene expression. Sodium butyrate can be used in research related to various cancers, inflammatory bowel disease, and sickle cell anemia.

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  • Purity: 99.76%
  • CAS No.: 156-54-7
  • 화학식: C4H7NaO2
  • 분자량:110.09
  • 보관:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Sodium butyrate Chemical Structure
    Sodium butyrate Chemical Structure
  • Experimental Validation Results for Sodium butyrate
  • Experimental Validation Results for Sodium butyrate
  • Experimental Validation Results for Sodium butyrate
  • Experimental Validation Results for Sodium butyrate
  • Experimental Validation Results for Sodium butyrate
CAS No.: 156-54-7
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IFRT-PCRELISAIn Vivo Efficacy StudyWB
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  • Sodium butyrate Chemical Structure
    Sodium butyrate Chemical Structure
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  • 1/16

    Sodium butyrate purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2023 Dec;15(2):2249143. [Abstract]

    Customer Validation
     Sodium butyrate (BA, 150 mg/kg; i.p.; four times at 2-day intervals). Images of B16-F0 tumors in mice at day 15 post-tumor implantation.

  • 1/16

    Sodium butyrate purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2022 Jan 3;41(1):1. [Abstract]

    Customer Validation
     P. loescheii colonization and butyrate supplementation downregulate IL-1β and TNF-α in colonic macrophages.In the B16F10 melanoma model,the C57BL/6 mice were orally administrated with Prevotellaceae loescheii (P. loescheii) (1 × 108 CFU/mouse/every 2 days) or Sodium butyrate (1 g/kg) for 1 week during BMS-1 (10 mg/kg)-treatment (n = 10). Representative images of immunostaining analysis of CD68+iNOS+ and CD68+CD206+ cells in colonic tissues and corresponding quantitative analysis. Scale bars, 20 μm.

  • 1/16

    Sodium butyrate purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2022 Jan 3;41(1):1. [Abstract]

    Customer Validation
     P. loescheii colonization and butyrate supplementation downregulate IL-1β and TNF-α in colonic macrophages. In the B16F10 melanoma model, the C57BL/6 mice were orally administrated with Prevotellaceae loescheii (P. loescheii) (1 × 108 CFU/mouse/every 2 days) or Sodium butyrate (1 g/kg) for 1 week during BMS-1 (10 mg/kg)-treatment (n = 10). M1 marker (iNOS and CXCL9) and M2 marker (CD206 and Arg-1) in colonic macrophages were measured by qPCR.

  • 1/16

    Sodium butyrate purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2022 Jan 3;41(1):1. [Abstract]

    Customer Validation
     P. loescheii colonization and butyrate supplementation downregulate IL-1β and TNF-α in colonic macrophages. In the B16F10 melanoma model, the C57BL/6 mice were orally administrated with Prevotellaceae loescheii (P. loescheii) (1 × 108 CFU/mouse/every 2 days) or Sodium butyrate (1 g/kg) for 1 week during BMS-1 (10 mg/kg)-treatment (n = 10). The M1 factors (IL-1β and TNF-α) and M2 factors (TGF-β and IL-10) in colonic macrophages were determined by ELISA.

  • 1/16

    Sodium butyrate purchased from MedChemExpress. Usage Cited in: Neurobiol Dis. 2018 Mar:111:12-25. [Abstract]

    Customer Validation
     Cdc42-Rac1 activation mediates the effect of SB on microglial process elongation. Representative images showing the activation effect of Cdc42 and Rac1 by Sodium butyrate (SB) (5 mM) at different time points (5, 10 min) in primary cultured microglia.

  • Sodium butyrate