Antioxidant agent-22
Antioxidant agent-22 is a paraben derivative tetracyclic spermine cyclotriphosphazene compound. Antioxidant agent-22 exhibits antioxidant, anti-Inflammatory, and apoptotic activities. Antioxidant agent-22 significantly upregulates CAT, SOD, caspase-3 and IL-6 expression, suppresses GSH, IL-1β, and reduces BCL-2 and BAX levels. Antioxidant agent-22 can be used for the research of cancer, such as lung cancer.
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- CAS No.: 2996086-75-8
- 화학식: C32H48N7O6P3
- 분자량:719.69
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
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- 순도&문서
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Biological Activity
제품 설명
IC50 & Target
[1]|
IL-6 |
IL-1β |
Caspase 3 |
Bax |
Bcl-2 |
In Vitro
Antioxidant agent-22 (Compound 5) (1.56-100 μM) exhibits cytotoxic activity against A549 human lung adenocarcinoma cells with an IC50 of 12.650 μM and minimal toxicity in MRC-5 human lung fibroblast cells[1].
Antioxidant agent-22 increases the expression of antioxidant (CAT, GSS, SOD), anti-inflammatory (IL-6), Caspase-3 and decreases apoptotic BCL-2 and BAX genes in A549 human lung adenocarcinoma cells[1].
Antioxidant agent-22 exhibits antioxidant activity by reducing GSH levels, anti-inflammatory activity by reducing IL-1β levels, and pro-apoptotic activity by increasing Caspase-3 levels in A549 human lung adenocarcinoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2996086-75-8
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분자량 719.69
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화학식 C32H48N7O6P3
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SMILES
CCCCOC(C(C=C1)=CC=C1OP2(OC3=CC=C(C(OCCCC)=O)C=C3)=NP4(N5CCCN4)=NP6(N(CCCC5)CCCN6)=N2)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antioxidant agent-22 Related Classifications
HY-181174 Related Classifications
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Keywords
- Antioxidant agent-22
- 2996086-75-8
- Antioxidant agent22
- Antioxidant agent 22
- SOD
- Glutathione Peroxidase
- Caspase
- Interleukin Related
- Bcl-2 Family
- Apoptosis
- human lung adenocarcinoma
- catalase
- caspase-3
- B-cell lymphoma 2
- MRC-5 human lung fibroblast cells
- superoxide dismutase
- lung cancer cells
- non-small cell lung cancer
- A549 human lung adenocarcinoma cells
- normal lung fibroblasts
- Inhibitor
- inhibitor
- inhibit