Cat. No.: HY-161659

Apoptosis inducer 19

고객리뷰

Based on 1 Customer Validation

Apoptosis inducer 19 (Compound 7g) is an Apoptosis inducer. Apoptosis inducer 19 elevates expression of pro-apoptotic proteins (Bax and caspase-3) and downregulates anti-apoptotic protein (Bcl-2). Apoptosis inducer 19 upregulates cellular reactive oxygen species (ROS) levels and disrupts mitochondrial membrane potential (MMP). Apoptosis inducer 19 can be used for triple-negative breast cancer (TNBC) research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 98.31%
CAS No.: 3049296-75-2
화학식: C₂₂H₂₃NO₄
분자량:365.42

보관:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Apoptosis inducer 19 Chemical Structure

CAS No.: 3049296-75-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
용액&용해도
- In Vitro
- In Vivo
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

Bcl-2

Bax

Caspase 3

All Bcl-2 Family Isoforms :

All Caspase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	17.12 μM Compound: 7g	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB method Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs by SRB method	[PMID: 38750906]
HCT-116	IC₅₀	18.3 μM Compound: 7g	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by SRB method Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by SRB method	[PMID: 38750906]
HEK293	IC₅₀	39.05 μM Compound: 7g	Antiproliferative activity against HEK293 cells assessed as inhibition of cell growth measured after 48 hrs by SRB method Antiproliferative activity against HEK293 cells assessed as inhibition of cell growth measured after 48 hrs by SRB method	[PMID: 38750906]
MCF7	IC₅₀	16.2 μM Compound: 7g	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by SRB method Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by SRB method	[PMID: 38750906]
MDA-MB-231	IC₅₀	9.42 μM Compound: 7g	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by SRB method Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by SRB method	[PMID: 38750906]
MDA-MB-468	IC₅₀	10.13 μM Compound: 7g	Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by SRB method Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by SRB method	[PMID: 38750906]

Chemical Information

CAS No. 3049296-75-2
Appearance Solid
분자량 365.42
화학식 C₂₂H₂₃NO₄
Color Off-white to light yellow
SMILES

COC1=CC=C(/C=C/C(C2=CC=C(OCC(N3CCCC3)=O)C=C2)=O)C=C1
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 50 mg/mL (136.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7366 mL

13.6829 mL

27.3658 mL

5 mM

0.5473 mL

2.7366 mL

5.4732 mL

10 mM

0.2737 mL

1.3683 mL

2.7366 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (6.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kumar P, et al. Design, synthesis, and biological evaluation of chalcone acetamide derivatives against triple negative breast cancer. Bioorg Med Chem Lett. 2024 Jul 15;107:129795. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.7366 mL	13.6829 mL	27.3658 mL	68.4144 mL
	5 mM	0.5473 mL	2.7366 mL	5.4732 mL	13.6829 mL
	10 mM	0.2737 mL	1.3683 mL	2.7366 mL	6.8414 mL
	15 mM	0.1824 mL	0.9122 mL	1.8244 mL	4.5610 mL
	20 mM	0.1368 mL	0.6841 mL	1.3683 mL	3.4207 mL
	25 mM	0.1095 mL	0.5473 mL	1.0946 mL	2.7366 mL
	30 mM	0.0912 mL	0.4561 mL	0.9122 mL	2.2805 mL
	40 mM	0.0684 mL	0.3421 mL	0.6841 mL	1.7104 mL
	50 mM	0.0547 mL	0.2737 mL	0.5473 mL	1.3683 mL
	60 mM	0.0456 mL	0.2280 mL	0.4561 mL	1.1402 mL
	80 mM	0.0342 mL	0.1710 mL	0.3421 mL	0.8552 mL
	100 mM	0.0274 mL	0.1368 mL	0.2737 mL	0.6841 mL

Keywords

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Apoptosis inducer 19

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Pyroptosis Compound Library

Anti-Breast Cancer Compound Library

Mitochondria-Targeted Compound Library

Cell Death Library

Multi-Target Compound Library

Mitophagy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

All Bcl-2 Family Isoforms

All Caspase Isoforms

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

Apoptosis inducer 19

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Pyroptosis Compound Library

Anti-Breast Cancer Compound Library

Mitochondria-Targeted Compound Library

Cell Death Library

Multi-Target Compound Library

Mitophagy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

All Bcl-2 Family Isoforms

All Caspase Isoforms

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

Apoptosis inducer 19 Related Classifications

HY-161659 Related Classifications