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GSDMD - gasdermin D Gene

Also Known as DF5L; DFNA5L; FKSG10; GSDMDC1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79792

About GSDMD

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,553,387-143,563,062 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele, 187 orthologues and 4 paralogues. Ubiquitous expression in spleen (RPKM 35.6), duodenum (RPKM 18.8) and 24 other tissues.

Summary

Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]

GSDMD Products (2)

mRNA	Protein	Name
NM_001166237.1	NP_001159709.1	gasdermin-D
NM_024736.7	NP_079012.3	gasdermin-D

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	27281216	GOA
enables phosphatidylinositol-4-phosphate binding	IDA IDA: Inferred from direct assay	36227980	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables wide pore channel activity	IDA IDA: Inferred from direct assay	32109412	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	32109412	GOA
involved in positive regulation of interleukin-1 production	IDA IDA: Inferred from direct assay	33883744	GOA
involved in positive regulation of interleukin-18 production	IDA IDA: Inferred from direct assay	33883744	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	33883744	GOA
involved in protein secretion	IDA IDA: Inferred from direct assay	33883744	GOA
involved in pyroptotic cell death	IDA IDA: Inferred from direct assay	32109412	GOA
involved in pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	28392147	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in membrane	IDA IDA: Inferred from direct assay	32109412	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	32109412	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	33883744	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSDMD Protein Structure

Gasdermin

0
100
200
300
400
484 a.a.

Protein Preferred Names	Protein Names
gasdermin-D	gasdermin domain containing 1

GSDMD Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GSDMD	P57764	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	GSDMD	P57764	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	GSDMD	P57764	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	GSDMD	P57764	ASPG	Homo sapiens	Q86U10	Y2H Prey Pooling	32296183
Intra	GSDMD	P57764	ASPG	Homo sapiens	Q86U10	Validated Y2H	32296183
Intra	GSDMD	P57764	ASPG	Homo sapiens	Q86U10	Y2H Array	32296183
Intra	GSDMD	P57764	KCTD6	Homo sapiens	Q8NC69	Validated Y2H	32296183
Intra	GSDMD	P57764	KCTD6	Homo sapiens	Q8NC69	Validated Y2H	25416956
Intra	GSDMD	P57764	KCTD6	Homo sapiens	Q8NC69	Y2H Array	32296183
Intra	GSDMD	P57764	KCTD6	Homo sapiens	Q8NC69	Y2H Prey Pooling	25416956
Intra	GSDMD	P57764	KCTD6	Homo sapiens	Q8NC69	Y2H Prey Pooling	32296183
Intra	GSDMD	P57764	ZBTB33	Homo sapiens	Q86T24	Validated Y2H	32296183
Intra	GSDMD	P57764	ZBTB33	Homo sapiens	Q86T24	Y2H Prey Pooling	32296183
Intra	GSDMD	P57764	ZBTB33	Homo sapiens	Q86T24	Y2H Array	32296183
Cross	GSDMD	P57764	N	SARS-CoV-2	P0DTC9	Anti Bait CoIP	34296442
Cross	GSDMD	P57764	N	SARS-CoV-2	P0DTC9	Pull Down	34296442
Intra	GSDMD	P57764	PSMA1	Homo sapiens	P25786	Y2H Prey Pooling	32296183
Intra	GSDMD	P57764	PSMA1	Homo sapiens	P25786	Y2H Array	32296183
Intra	GSDMD	P57764	ZNF558	Homo sapiens	Q96NG5	Y2H Prey Pooling	32296183
Intra	GSDMD	P57764	ZNF558	Homo sapiens	Q96NG5	Y2H Array	32296183
Intra	GSDMD	P57764	ZNF558	Homo sapiens	Q96NG5	Validated Y2H	32296183
Intra	GSDMD	P57764	CASP1	Homo sapiens	P29466	Pull Down	34296442
Intra	GSDMD	P57764	CASP1	Homo sapiens	P29466	Protease Assay	34296442
Intra	GSDMD	P57764	ZNF426	Homo sapiens	Q9BUY5	Validated Y2H	32296183
Intra	GSDMD	P57764	ZNF426	Homo sapiens	Q9BUY5	Y2H Array	32296183
Intra	GSDMD	P57764	ZNF426	Homo sapiens	Q9BUY5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

GSDMD Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P83706	GSDMD Antibody (YA3443)	WB	Human
HY-P83706A	GSDMD Antibody (YA3443)(PBS only)	WB	Human
HY-P85810	GSDMD (N-terminal) Antibody (YA5502)	WB, ICC/IF, ELISA	Human, Mouse, Rat
HY-P86158	Cleaved N-terminal GSDMD Antibody (YA5850)	WB, ICC/IF, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Cinca Syndrome	CINCA Nomid Cryopyrin-Associated Periodic Syndrome 3 Chronic Neurologic Cutaneous And Articular Syndrome Multisystem Inflammatory Disease, Neonatal-Onset Caps3 Chronic Infantile Neurological Cutaneous Articular Syndrome Infantile-Onset Multisystem Inflammatory Disease Iomid Syndrome Neonatal-Onset Multisystem Inflammatory Disease Nomid Syndrome Prieur-Griscelli Syndrome Neonatal Onset Multisystem Inflammatory Disease Chronic Infantile Neurological, Cutaneous And Articular Syndrome Iomid Infantile Onset Multisystem Inflammatory Disease Prieur Griscelli Syndrome Chronic Infantile Neurological Cutaneous And Articular Syndrome Chronic, Infantile, Neurological, Cutaneous, Articular Syndrome Chronic Infantile Neurologic Cutaneous And Articular Syndrome Chronic Infantile Neurological, Cutaneous, And Articular Syndrome Cryopyrin-Associated Periodic Syndromes
Familial Cold Autoinflammatory Syndrome	Familial Cold Urticaria Fcas Familial Polymorphous Cold Eruption Fcu Cold Hypersensitivity
Bacterial Sepsis
Salmonellosis	Salmonella Infections Salmonella Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-B0240	Disulfiram		99.77%	Unkown
HY-B0240R	Disulfiram (Standard)		99.54%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Phase
HY-19309	ABT-546 hydrochloride		/	Phase 1

Pre-clinical Phase

Bioactive Molecules (33)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-13453	BAY 11-7082		99.98%	Unkown
HY-127019	Nigericin		99.64%	Unkown
HY-100381	Nigericin sodium salt		99.60%	Unkown
HY-100573	Necrosulfonamide		98.61%	Unkown
HY-111674	LDC7559	Inhibitor	99.51%	Unkown
HY-171006	IRF1-IN-1	Inhibitor	99.72%	Unkown
HY-N0816	Polyphyllin VI		98.49%	Unkown
HY-N2414	Periplogenin		≥99.70%	Unkown
HY-111675	Ac-FLTD-CMK	Inhibitor	99.18%	Unkown
HY-171007	IRF1-IN-2		99.83%	Unkown
HY-N0218	Benzoylmesaconine	Inhibitor	99.56%	Unkown
HY-18711A	SCR-1481B1	Inhibitor	99.95%	Unkown
HY-152670	JC2-11	Inhibitor	98.03%	Unkown
HY-N7400	Phaseoloidin		99.92%	Unkown
HY-RS05857	GSDMD Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-156374	D359-0396	Inhibitor	99.98%	Unkown
HY-161727	P2Y14R antagonist 1		98.76%	Unkown
HY-100573A	(E/Z)-Necrosulfonamide		98.03%	Unkown
HY-100573S	Necrosulfonamide-d4		99.65%	Unkown
HY-130480	Fructose-arginine	Inhibitor	98.32%	Unkown
HY-173234	GI-Y2	Inhibitor	/	Unkown
HY-P11603	SK56	Inhibitor	/	Unkown
HY-RS16519	Gsdmd Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-135283	ABT-546		/	Unkown
HY-161332	Antitumor agent-143		/	Unkown
HY-172788	NLRP3-IN-78	Inhibitor	/	Unkown
HY-175640	Troponin-IN-1	Inhibitor	/	Unkown
HY-179348	DPP9-IN-2		/	Unkown
HY-180830	NLRP3-IN-86	Inhibitor	/	Unkown
HY-181168	Lb54		/	Unkown
HY-182066	Photosensitizer-9	Activator	/	Unkown
HY-185207	CQ80	Inducer	/	Unkown
HY-RS22950	Gsdmd Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GSDMD	MGD	MGI:1916396
Macaca mulatta	GSDMD	VGNC	VGNC:73232
Rattus norvegicus	GSDMD	RGD	RGD:1307261
Canis familiaris	GSDMD	VGNC	VGNC:41526
Felis catus	GSDMD	VGNC	VGNC:62726
Bos taurus	GSDMD	VGNC	VGNC:29675
Others	GSDMD	NCBI