Grp94-IN-3
Grp94-IN-3 (Compound 47) is a selective ATP competitive inhibitor of Grp94, with a Kd value of 76 nM. Grp94-IN-3 has a much lower affinity for Hsp90α, with a Kd value of 9.17 μM. Grp94-IN-3 induces the degradation of integrin α2 (Integrin α2) in MDA-MB-231 cells and reduces the intracellular accumulation of mutant cardiac proteins in human trabecular meshwork cells. Grp94-IN-3 can be used for the study of metastatic cancer and open-angle glaucoma.
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- 화학식: C22H24ClN3O4
- 분자량:429.90
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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GRP94 76 nM (Kd) |
HSP90α 9.17 μM (Kd) |
Chemical Information
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분자량 429.90
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화학식 C22H24ClN3O4
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SMILES
O=C(OC)C(C(O)=CC(O)=C1Cl)=C1CCN2N=NC=C2CC3=CC=CC=C3CCC
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Grp94-IN-3 Related Classifications
HY-180195 Related Classifications
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