NV03
Based on 1 Customer Validation
NV03 is a potent and selective antagonist of Ubiquitin-like with PHD and RING finger domains 1 (UHRF1)-H3K9me3 interaction by binding to UHRF1 tandem tudor domain, with a Kd of 2.4 μM. NV03 is also a ligand for E3 ligase. NV03 can be studied in anticancer research.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.77%
- CAS No.: 2448341-58-8
- 화학식: C19H27N5O2S
- 분자량:389.51
-
보관:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
용액&용해도
- 순도&문서
- References
-
Help & FAQs
-
HY-103236
NSC232003UHRF1 Inhibitor -
HY-10587
BIX-01294G9a/GLP Inhibitor -
HY-W004883
3-Amino-4,6-dimethylpyridineUHRF1 Inhibitor -
HY-133129
MS1943EZH2 HyT Degrader -
HY-15227
EPZ004777DOT1L Inhibitor -
HY-19715
SGC707PRMT3 Inhibitor -
HY-117690
dBRD9BRD9 PROTAC Degrader -
HY-12335
UNC0379SETD8 Inhibitor -
HY-12583
A-366G9a Inhibitor -
HY-15273
UNC0638G9a/GLP Inhibitor -
HY-B1322
Amodiaquine dihydrochloride dihydrateAntimalarial Agent -
HY-145322
TMX-4116CK1α Degrader
All Histone Methyltransferase Isoforms
More
Biological Activity
제품 설명
IC50 & Target
|
UHRF1 |
In Vitro
Chemical Information
-
CAS No. 2448341-58-8
-
Appearance Solid
-
분자량 389.51
-
화학식 C19H27N5O2S
-
Color White to light yellow
-
SMILES
O=C1N(CC(NCCCN(CC)CC)=O)N=C(C)N2C1=C(C)C3=C2C=CS3
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
용액&용해도
In Vitro:
DMSO : 33.33 mg/mL (85.57 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.42 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
-
Data Sheet (272 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5673 mL | 12.8366 mL | 25.6733 mL | 64.1832 mL |
| 5 mM | 0.5135 mL | 2.5673 mL | 5.1347 mL | 12.8366 mL | |
| 10 mM | 0.2567 mL | 1.2837 mL | 2.5673 mL | 6.4183 mL | |
| 15 mM | 0.1712 mL | 0.8558 mL | 1.7116 mL | 4.2789 mL | |
| 20 mM | 0.1284 mL | 0.6418 mL | 1.2837 mL | 3.2092 mL | |
| 25 mM | 0.1027 mL | 0.5135 mL | 1.0269 mL | 2.5673 mL | |
| 30 mM | 0.0856 mL | 0.4279 mL | 0.8558 mL | 2.1394 mL | |
| 40 mM | 0.0642 mL | 0.3209 mL | 0.6418 mL | 1.6046 mL | |
| 50 mM | 0.0513 mL | 0.2567 mL | 0.5135 mL | 1.2837 mL | |
| 60 mM | 0.0428 mL | 0.2139 mL | 0.4279 mL | 1.0697 mL | |
| 80 mM | 0.0321 mL | 0.1605 mL | 0.3209 mL | 0.8023 mL |
NV03 Related Classifications
HY-125292 Related Classifications
Powered by Bioz