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Cat. No.: HY-155397

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PRO-HD2

PRO-HD2 is a HDAC6 PROTAC degrader. PRO-HD2 exerts antiproliferative activity in leukemia cells. PRO-HD2 can be used for leukemia research.

(Pink: HDAC6 ligand (HY-175627); Blue: Cereblon ligand (HY-41547); Black: linker).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3126555-89-0
화학식: C₃₈H₃₉N₅O₅S
분자량:677.81

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

PRO-HD2 Chemical Structure

CAS No.: 3126555-89-0

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

PRO-HD2 is a HDAC6 PROTAC degrader. PRO-HD2 exerts antiproliferative activity in leukemia cells. PRO-HD2 can be used for leukemia research^[1].
(Pink: HDAC6 ligand (HY-175627); Blue: Cereblon ligand (HY-41547); Black: linker).

IC₅₀ & Target

^[1]

HDAC6

Cereblon

All PROTACs Isoforms :

All HDAC Isoforms :

In Vitro

OthersAnti-cancer

Others

PRO-HD2 (500 nM-5 μM; 24 h) efficiently degrades HDAC6 in A549 cells. After 24 h of incubation, almost complete depletion of HDAC6 is observed at concentrations ≥ 500 nM^[1].
PRO-HD2 (0.5-1 μM; 12-48 h) efficiently degrades HDAC6 in MCF-7, HCT-116, A549 and Jurkat cells^[1].

Anti-cancer

PRO-HD2 (48 h) inhibits the proliferation of Jurkat cells, with an IC₅₀ of 2.62 μM after 48 h of incubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

A549 cells (adenocarcinomic human alveolar basal epithelial cells)
Concentration:

500 nM, 1 μM, 5 μM
Incubation Time:

24 h
Result:

Nearly completely depleted HDAC6 protein.
Exhibited higher HDAC6 degradation efficiency compared to PRO-HD1 and PRO-HD3.

Related Protocols :

Cell Viability Determination by MTT Colorimetric Assay

Chemical Information

CAS No. 3126555-89-0
분자량 677.81
화학식 C₃₈H₃₉N₅O₅S
SMILES

S=C1N(CC2=CC=C(C3=CC=C(CNCCCCCCNC4=CC=CC(C(N5C6CCC(NC6=O)=O)=O)=C4C5=O)C=C3)C=C2)C=CC=C1O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jia Q, et al. Cell-Specific Degradation of Histone Deacetylase Using Warhead-Caged Proteolysis Targeting Chimeras. Analytical chemistry. 2023 Nov 14;95(45):16474-16480. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

PRO-HD2

All PROTACs Isoforms

All HDAC Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

PRO-HD2 Related Classifications

HY-155397 Related Classifications

Bioz

Keywords

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