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Cat. No.: HY-117688

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WJ35435

WJ35435 is a dual-targeted anticancer hybrid that induces anti-HDAC (in particular HDAC1 and HDAC6) and anti-topoisomerase I activities that causes DNA damage associated with a low DNA repair capability and induces cell cycle arrest at G1- and G2-phase to apoptosis. WJ35435 induces histone H3 acetylation and phosphorylation, α-tubulin acetylation and γ-H2AX formation to achieve anti-HDAC effect. WJ35435 is promising for research of cancer.

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CAS No.: 1620054-84-3
화학식: C₂₀H₂₁N₃O₃
분자량:351.40

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

WJ35435 Chemical Structure

CAS No.: 1620054-84-3

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All HDAC Isoforms :

All Topoisomerase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	0.16 μM Compound: 41; WJ36435	Inhibition of colony formation in human DU-145 cells incubated for 10 days by crystal violet method Inhibition of colony formation in human DU-145 cells incubated for 10 days by crystal violet method	[PMID: 33143937]
DU-145	IC₅₀	0.33 nM Compound: 15; WJ35435	Antiproliferative activity against human DU-145 cells incubated for 48 hrs by Sulforhodamine B staining method Antiproliferative activity against human DU-145 cells incubated for 48 hrs by Sulforhodamine B staining method	[PMID: 33077264]
PC-3	IC₅₀	0.31 μM Compound: 41; WJ36435	Inhibition of colony formation in human PC-3 cells incubated for 10 days by crystal violet method Inhibition of colony formation in human PC-3 cells incubated for 10 days by crystal violet method	[PMID: 33143937]
PC-3	IC₅₀	0.39 nM Compound: 15; WJ35435	Antiproliferative activity against human PC-3 cells incubated for 48 hrs by Sulforhodamine B staining method Antiproliferative activity against human PC-3 cells incubated for 48 hrs by Sulforhodamine B staining method	[PMID: 33077264]

Chemical Information

CAS No. 1620054-84-3
분자량 351.40
화학식 C₂₀H₂₁N₃O₃
SMILES

O=C(C1=CC=CC2=CC3=C(N=C21)C=CC=C3)NCCCCCC(NO)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yu C C, et al. A novel small molecule hybrid of vorinostat and DACA displays anticancer activity against human hormone-refractory metastatic prostate cancer through dual inhibition of histone deacetylase and topoisomerase I[J]. Biochemical pharmacology, 2014, 90(3): 320-330. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

WJ35435

All HDAC Isoforms

All Topoisomerase Isoforms

Biological Activity

제품 설명

Cellular Effect

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Bioz

Keywords

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WJ35435

All HDAC Isoforms

All Topoisomerase Isoforms

Biological Activity

제품 설명

Cellular Effect

Chemical Information

순도&문서

References

Calculators

Help & FAQs

WJ35435 Related Classifications

HY-117688 Related Classifications

Bioz

Keywords

Your Recently Viewed Products