XY028-140
Based on 1 publication(s) in Google Scholar
XY028-140 is a PROTAC-type degrader targeting CDK4/6, which degrades CDK4/6 by recruiting CRBN-type E3 ligase. XY028-140 can be used in CDK4/6-mediated cancer-related research.
(Pink: Cdk6/cyclin D2 and CDK4 ligand (HY-50767); Blue: Cereblon ligand (HY-41547); Black: linker (HY-W007408)).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 98.52%
- CAS No.: 2229974-83-6
- 화학식: C39H40N10O7
- 분자량:760.80
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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HY-129180
XY028-133CDK4/6 PROTAC Degrader -
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PROTAC CDK2/9 Degrader-1PROTAC CDK2/9 Degrader -
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AbemaciclibCDK4/6 Inhibitor -
HY-136250
BSJ-03-204CDK4/CCND1 Complex Inhibitor, CDK6/CCND1 Complex Inhibitor -
HY-134582
dCBP-1PROTAC p300/CBP Degrader -
HY-139039
BSJ-4-116PROTAC CDK12 Degrader -
HY-15777
RibociclibCDK4/6 Inhibitor -
HY-101488
CC-885CRBN Modulator/GSPT1 Molecular Glue Degrader -
HY-50767
PalbociclibCDK4/6 Inhibitor -
HY-136252
BSJ-04-132PROTAC CDK4 Degrader -
HY-111556
BSJ-03-123CDK6 PROTAC Degrader -
HY-144981
HQ461Cyclin K Degrader
Publications Citing Use of MedChemExpress (MCE) XY028-140
MoreAll PROTACs Isoforms
More
Biological Activity
제품 설명
IC50 & Target
[1]|
CDK4 |
CDK6 |
Cereblon |
In Vitro
XY028-140 (0.3 or 1 μM; 24 h) inhibits CDK4/6 expression and CDK4/6 activity in A375 melanoma and T47D breast cancer cells[1].
XY028-140 inhibits the proliferation of T47D breast cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:T47D
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Concentration:0.03, 0.1, 0.3, 1, 3 μM
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Incubation Time:11 days
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Result:Inhibited the proliferation of T47D breast cancer cells.
Chemical Information
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CAS No. 2229974-83-6
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Appearance Solid
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분자량 760.80
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화학식 C39H40N10O7
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Color White to yellow
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SMILES
O=C1C2=C(C(N1C3C(NC(CC3)=O)=O)=O)C(NCC(N4CCN(CC4)C5=CN=C(NC6=NC(N(C7CCCC7)C(C(C(C)=O)=C8C)=O)=C8C=N6)C=C5)=O)=CC=C2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Biochem Pharmacol
Momordin Ic suppresses breast cancer growth by targeting ACTL8‑dependent glutamine metabolism and PI3K/AKT/mTOR-MYC. [Abstract]2026 May:247:117761. PMID: 41621692
용액&용해도
In Vitro:
DMSO : 5.56 mg/mL (7.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 0.56 mg/mL (0.74 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 0.56 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.6 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (283 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3144 mL | 6.5720 mL | 13.1441 mL | 32.8601 mL |
| 5 mM | 0.2629 mL | 1.3144 mL | 2.6288 mL | 6.5720 mL |
XY028-140 Related Classifications
HY-138946 Related Classifications
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