Cat. No.: HY-18313

S6K1-IN-1

Customer Review

Based on 1 Customer Validation

S6K1-IN-1 is a selective S6K1 inhibitor with an IC₅₀ value of 52 nM. S6K1-IN-1 can be used in the research of obesity and insulin resistance-related diseases.

For research use only. We do not sell to patients.

Purity: 99.71%
CAS No.: 1265789-88-5
Formula: C₁₇H₁₈N₄O₃S
Molecular Weight:358.41

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

S6K1-IN-1 Chemical Structure

CAS No.: 1265789-88-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

S6K1-IN-1 is a selective S6K1 inhibitor with an IC₅₀ value of 52 nM. S6K1-IN-1 can be used in the research of obesity and insulin resistance-related diseases^[1].

IC₅₀ & Target^[1]

p70S6K1

52 nM (IC₅₀)

JAK3

CLK1

All Ribosomal S6 Kinase (RSK) Isoforms :

All JAK Isoforms :

All CDK Isoforms :

In Vitro

S6K1-IN-1 (compound 18) (1-10 μM) exhibits only low-level inhibition against JAK3, CLK1, and CHEK2 in a panel of 43 kinases, and shows excellent selectivity for S6K1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1265789-88-5
Appearance Solid
Molecular Weight 358.41
Formula C₁₇H₁₈N₄O₃S
Color Off-white to pink
SMILES

O=C(C1=C(NC(NC2=CC3=C(NN=C3)C=C2)=O)SC(C(C)(C)C)=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (348.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7901 mL

13.9505 mL

27.9010 mL

5 mM

0.5580 mL

2.7901 mL

5.5802 mL

10 mM

0.2790 mL

1.3951 mL

2.7901 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ye P, et al. Potent and selective thiophene urea-templated inhibitors of S6K. Bioorg Med Chem Lett. 2011 Jan 15;21(2):849-52. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.7901 mL	13.9505 mL	27.9010 mL	69.7525 mL
	5 mM	0.5580 mL	2.7901 mL	5.5802 mL	13.9505 mL
	10 mM	0.2790 mL	1.3951 mL	2.7901 mL	6.9753 mL
	15 mM	0.1860 mL	0.9300 mL	1.8601 mL	4.6502 mL
	20 mM	0.1395 mL	0.6975 mL	1.3951 mL	3.4876 mL
	25 mM	0.1116 mL	0.5580 mL	1.1160 mL	2.7901 mL
	30 mM	0.0930 mL	0.4650 mL	0.9300 mL	2.3251 mL
	40 mM	0.0698 mL	0.3488 mL	0.6975 mL	1.7438 mL
	50 mM	0.0558 mL	0.2790 mL	0.5580 mL	1.3951 mL
	60 mM	0.0465 mL	0.2325 mL	0.4650 mL	1.1625 mL
	80 mM	0.0349 mL	0.1744 mL	0.3488 mL	0.8719 mL
	100 mM	0.0279 mL	0.1395 mL	0.2790 mL	0.6975 mL

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S6K1-IN-1

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

MAPK Compound Library

Protein Tyrosine Kinase Compound Library

Stem Cell Signaling Compound Library

Anti-Aging Compound Library

Differentiation Inducing Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

Glutamine Metabolism Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Obesity Compound Library

Anti-Liver Cancer Compound Library

Anti-Prostate Cancer Compound Library

Cancer Stem Cells Compound Library

Autoimmune Disease Compound Library

Highly Selective Inhibitors Library

Serine/Threonine Kinase Inhibitor Library

Anti-Drug-Resistant Compound Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Anti-Rheumatic Arthritis Compound Library

Posttranslational Modification Library

High-Efficiency Gene Editing Compound Library

All Ribosomal S6 Kinase (RSK) Isoforms

All JAK Isoforms

All CDK Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

S6K1-IN-1 Related Classifications

HY-18313 Related Classifications