1024 Results for "

neuronal

" in MedChemExpress (MCE) Product Catalog:
Products (1024)

1024 Results for "neuronal" in MCE Product Catalog:

11
11 Cited Publications
Cat. No.: HY-153169
CAS No.: 2754428-18-5
Purity:  99.30%
Synonyms: 6PPD-Quinone
6PPD-Q (6PPD-Quinone) is an environmental pollutant that can be detected in human urine and is widely present in the environment. 6PPD-Q targets and binds to CNR2, CNR1, AA2AR, LCAT, and TRPA1, with CNR2 exhibiting the highest binding affinity, potentially acting as a CNR2 receptor agonist to activate cannabinoid receptors. 6PPD-Q induces intestinal inflammation and barrier damage by disrupting mitochondrial function, reducing neuronal glycolysis metabolites and TCA cycle intermediates, and exacerbating α-synuclein (α-syn) aggregation. 6PPD-Q is applicable in research on environmental toxicology, neurodegenerative diseases, and inflammation-related disorders .
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10
10 Cited Publications
Cat. No.: HY-B1142
CAS No.: 940-69-2
Synonyms: (±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide
Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway .
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10
10 Cited Publications
Cat. No.: HY-N0570
CAS No.: 10597-60-1
Synonyms: DOPET; 3,4-Dihydroxyphenethyl alcohol; 3-Hydroxytyrosol
Hydroxytyrosol (DOPET; 3,4-Dihydroxyphenethyl alcohol) is an orally active, blood-brain barrier-permeable multi-active compound with multiple effects including antibacterial, antioxidant, anti-platelet aggregation, and neuroprotective activities. Hydroxytyrosol not only inhibits the growth of Vibrio by increasing bacterial membrane permeability, but also interacts with DNA and mediates supercoiled DNA relaxation. Meanwhile, Hydroxytyrosol effectively reduces thrombosis and inhibits lipid oxidation by inhibiting COX activity and promoting vascular nitric oxide production. In terms of neuroprotection, Hydroxytyrosol significantly alleviates neuronal apoptosis and inflammatory responses by up-regulating the expression level of ERβ, thereby improving cognitive function in Alzheimer's disease models. Hydroxytyrosol has been widely used in scientific research related to Vibrio infection, arterial thrombosis, Alzheimer's disease and other related fields .
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9
9 Cited Publications
Cat. No.: HY-Y1787
CAS No.: 108-59-8
Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis .
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8
8 Cited Publications
Cat. No.: HY-B0158
CAS No.: 65-46-3
Synonyms: Cytosine β-D-riboside; Cytosine-1-β-D-ribofuranoside
Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function .
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8
8 Cited Publications
Cat. No.: HY-101878
CAS No.: 60311-02-6
Purity:  99.72%
Synonyms: Sulforhodamine 101; SR101
Texas Red (Sulforhodamine 101) is an amphoteric rhodamine red fluorescent dye (excitation/emission: 586/605 nm). Texas Red is used extensively for investigating neuronal morphology and acts as acell type-selective fluorescent marker of astrocytes bothin vivoand in slice preparations .
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8
8 Cited Publications
Cat. No.: HY-P0117
CAS No.: 500992-11-0
Synonyms: Tat-NR2Bct; NA-1
Target:  

iGluR NO Synthase

Research Areas:  

Neurological Disease

Tat-NR2B9c (Tat-NR2Bct; NA-1) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy .
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8
8 Cited Publications
Cat. No.: HY-P0117A
CAS No.: 1834571-04-8
Synonyms: Tat-NR2Bct TFA; NA-1 TFA
Target:  

iGluR NO Synthase

Research Areas:  

Neurological Disease

Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c TFA also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy .
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7
7 Cited Publications
Cat. No.: HY-13694
CAS No.: 348-67-4
Purity:  99.86%
Synonyms: MRX-1024; D-Methionine
Methionine (MRX-1024; D-Methionine) is an effective chemoprotective agent which can also inhibit the neuronal activity through GABAA receptor activation.
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7
7 Cited Publications
Cat. No.: HY-105182
CAS No.: 131986-45-3
Purity:  99.52%
Synonyms: LY-246708
Target:  

mAChR

Research Areas:  

Neurological Disease

Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia .
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7
7 Cited Publications
Cat. No.: HY-B0495
CAS No.: 84057-84-1
Synonyms: LTG; BW430C
Research Areas:  

Neurological Disease Cancer

Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na + channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al .
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7
7 Cited Publications
Cat. No.: HY-110032
CAS No.: 113170-86-8
Synonyms: LTG isethionate; BW430C isethionate
Research Areas:  

Neurological Disease Cancer

Lamotrigine (BW430C) isethionate is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine isethionate selectively blocks voltage-gated Na + channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine isethionate can be used for the research of epilepsy, focal seizure, et al .
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7
7 Cited Publications
Cat. No.: HY-100807
CAS No.: 89-00-9
Purity:  99.85%
Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis .
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7
7 Cited Publications
Cat. No.: HY-18638
CAS No.: 30675-13-9
Synonyms: 4,5,6,7-Tetrachloroindan-1,3-dione
Target:  

Deubiquitinase

Research Areas:  

Neurological Disease

TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective neuronal ubiquitin C-terminal hydrolase (UCH-L3) inhibitor with an IC50 of 0.6 μM . TCID diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons .
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7
7 Cited Publications
Cat. No.: HY-A0067
CAS No.: 131-57-7
Synonyms: Benzophenone 3
Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .
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7
7 Cited Publications
Cat. No.: HY-128692
CAS No.: 67769-47-5
Purity:  99.67%
Luc Yellow CH dilithium is a high-intensity fluorescent probe containing free hydrazyl groups. Luc Yellow CH can react with fatty aldehydes at room temperature. Luc Yellow CH serves as a biological tracer to monitor neuronal branching, regeneration, gap junction detection and characterization, and selective ablation of cells after aldehyde fixation. Luc Yellow CH displays the maximum excitation/emission of 430 nm/540 nm, respectively .
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7
7 Cited Publications
Cat. No.: HY-W127715
CAS No.: 71206-95-6
Lucifer Yellow CH dipotassium is a high-intensity fluorescent probe containing free hydrazyl groups. Lucifer Yellow CH can react with fatty aldehydes at room temperature. Lucifer Yellow CH serves as a biological tracer to monitor neuronal branching, regeneration, gap junction detection and characterization, and selective ablation of cells after aldehyde fixation. Lucifer yellow CH displays the maximum excitation/emission of 430 nm/540 nm, respectively .
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7
7 Cited Publications
Cat. No.: HY-B1692
CAS No.: 15985-39-4
Synonyms: MSX; MSO
Target:  

Glutaminase

Research Areas:  

Neurological Disease

L-Methionine-DL-sulfoximine (MSX; MSO), a highly specific and irreversible inhibitor of Glutamine synthetase (GS), is also a potent convulsant which metabolically and morphologically primarily affects astroglia. L-Methionine-DL-sulfoximine has been employed to inhibit the Gln-dependent ammonia-stimulated neuronal toxicity in vitro, potentiating Gln deficit-dependent depression. L-Methionine-DL-sulfoximine tremendously increases the rate of release of fixed nitrogen in cyanobacteria. L-Methionine-DL-sulfoximine is a promising candidate for research in biofertilizers and convulsive seizures (CS) .
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6
6 Cited Publications
Cat. No.: HY-101712
CAS No.: 867164-40-7
Purity:  99.79%
Target:  

HSP

Research Areas:  

Neurological Disease

TRC051384 is a potent inducer of heat shock protein 70 (HSP70). TRC051384 exhibits protective effects against neuronal trauma via inhibition of necroptosis. TRC051384 can be used for the research of ischemic stroke .
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6
6 Cited Publications
Cat. No.: HY-105182A
CAS No.: 152854-19-8
Purity:  99.93%
Synonyms: LY 246708 tartrate
Target:  

mAChR

Research Areas:  

Neurological Disease

Xanomeline (LY 246708) is the potent agonist of muscarinic M1/M4 receptor with antipsychotic-like activity. Xanomeline (LY 246708) increases neuronal excitability. Xanomeline (LY 246708) can be used for the research of schizophrenia .
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