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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
699 Results for "
PI3K/AKT
" in MedChemExpress (MCE) Product Catalog:
Products (699)
699 Results for "PI3K/AKT" in MCE Product Catalog:
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13 Cited Publications
Synonyms: ALA; C18:3 (9Z,12Z,15Z); C18:3 n-3
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α-Linolenic acid sodium (ALA; C18:3 (9Z,12Z,15Z); C18:3 n-3) is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid sodium can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid sodium possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .
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13 Cited Publications
Synonyms: ALA free base; C18:3 (9Z,12Z,15Z) free base; C18:3 n-3 free base
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Cardiovascular Disease Natural Products Ulex europaeus L. Disease markers Plants Endogenous metabolite Disease Research Fields Cardiovascular System Disorder Labiatae Extract
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12 Cited Publications
Cat. No.: HY-N0103A
CAS No.: 145572-44-7
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12 Cited Publications
Cat. No.: HY-18676
CAS No.: 2070015-22-2
OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain) . OSU-T315 abrogates AKT activation by impeding AKT localization in lipid rafts and triggers caspase-dependent apoptosis in an ILK-independent manner . OSU-T315 causes cell death through apoptosis and autophagy .
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Lauraceae Extract Plants Lindera aggregata (Sims) Kosterm. Alkaloids Phenols Polyphenols Disease Research Fields Isoquinoline Alkaloids Endocrinology Cancer
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12 Cited Publications
Cat. No.: HY-N2515
CAS No.: 494753-69-4
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12 Cited Publications
Synonyms: Norcoclaurine; Demethyl-Coclaurine
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11 Cited Publications
Synonyms: Ononoside; Formononetin 7-O-β-D-glucopyranoside
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11 Cited Publications
Synonyms: 17α-Hydroxy-6α-methylprogesterone; U8840
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Medroxyprogesterone (17α-Hydroxy-6α-methylprogesterone) is a synthetic human variant of progesterone that is a progesterone receptor agonist with oral activity. Medroxyprogesterone can induce cell proliferation through the PI3K/Akt signaling pathway. Medroxyprogesterone has an inhibitory effect on atherosclerosis in mice. The progesterone agonist activity of Medroxyprogesterone is less effective than Medroxyprogesterone acetate (HY-B0469) .
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10 Cited Publications
Cat. No.: HY-N0847
CAS No.: 68370-47-8
Category:
Other Monoterpenes Terpenoids Other Diseases Plants Other Families Extract Disease Research Fields
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Zingiberaceae Extract Terpenoids Sesquiterpenes Plants Curcuma phaeocaulis Valeton Disease Research Fields Cancer
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Research Areas:
Onvoloxastat (ML355) is an orally active selective 12-LOX inhibitor with an IC50 of 0.34 μM. Onvoloxastat inhibits platelet activation by blocking thrombin- or thromboxane A2-induced phosphorylation of Akt, PI3K and Erk1/2. At low doses (1-20 μM), it mainly acts by reducing ROS levels, while at high doses (50 μM), it functions via activating the cAMP pathway. Onvoloxastat can be used in research related to thrombosis and diabetes .
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7 Cited Publications
Cat. No.: HY-N1381
CAS No.: 13137-64-9
Category:
Asclepiadaceae Extract Plants Periploca sepium Bunge Disease Research Fields Inflammation/Immunology Steroids
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Neurological Disease Metabolic Disease Inflammation/Immunology
Doxepin Hydrochloride is an orally active, blood-brain barrier penetrant tricyclic antidepressant with multiple activities including hypnosis, sedation, analgesia and vasodilation. Doxepin Hydrochloride enhances the expression of PSD-95 and synapsin 1 via the PI3K/AKT/mTOR signaling pathway, and is metabolized to DesmethylDoxepin Hydrochloride in vivo. Doxepin Hydrochloride can be used in research related to various diseases such as depression, anxiety, obesity and atopic dermatitis .
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Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
Doxepin is an orally active, blood-brain barrier penetrant tricyclic antidepressant with multiple activities including hypnosis, sedation, analgesia and vasodilation. Doxepin enhances the expression of PSD-95 and synapsin 1 via the PI3K/AKT/mTOR signaling pathway, and is metabolized to Desmethyldoxepin in vivo. Doxepin can be used in research related to various diseases such as depression, anxiety, obesity and atopic dermatitis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
