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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
262 Results for "
TLR-4
" in MedChemExpress (MCE) Product Catalog:
Products (262)
262 Results for "TLR-4" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-N1990
CAS No.: 94987-08-3
1
1
1 Cited Publications
Target:
Research Areas:
MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex antagonist. MD2-TLR4-IN-1 inhibits Lipopolysaccharides (HY-D1056) (LPS)-induced expression of TNF-α and IL-6 in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively. MD2-TLR4-IN-1 can be used for the study of acute lung injury (ALI) .
1
1 Cited Publications
Cat. No.: HY-B0012
CAS No.: 40391-99-9
Research Areas:
Pamidronic acid, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronic acid significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of OPG in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronic acid can inhibit the signaling of Wnt and β-catenin, and is applicable for research on osteoporosis and osteosarcoma [4].
1
1 Cited Publications
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Research Areas:
CAY10614 is a potent TLR4 antagonist. CAY10614 inhibits the lipid A-induced activation of TLR4, with an IC50 of 1.675 μM. CAY10614 can improve survival of mice in lethal endotoxin shock model .
1
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.
1
1 Cited Publications
Cat. No.: HY-P10208A
Target:
Research Areas:
1
1 Cited Publications
Cat. No.: HY-P73586Y
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: TLR4; CD284; Toll Like Receptor 4; Toll Like Receptor 4 Protein; Toll-Like Receptor 4; Homolog Of Drosophila Toll; HToll; CD284 Antigen; TLR-4; TOLL; ARMD10
Species:
Human
Source:
Sf9 insect cells
1
Research Areas:
Pamidronate disodium (CGP 23339A), the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronate disodium significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of osteoprotegerin in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronate disodium can inhibit the signaling of Wnt and β-catenin, and is applicable for research on osteoporosis and osteosarcoma [4].
1
1 Cited Publications
Cat. No.: HY-B0730
CAS No.: 109552-15-0
Research Areas:
Pamidronate disodium pentahydrate, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronate disodium pentahydrate significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of osteoprotegerin in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronate disodium pentahydrate can inhibit the signaling of Wnt and β-catenin, and is applicable for research on osteoporosis and osteosarcoma [4].
1
1 Cited Publications
Cat. No.: HY-N2345
CAS No.: 23567-23-9
1
1 Cited Publications
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Research Areas:
L48H37 is an analog of Curcumin (HY-N0005) with improved chemical stability. L48H37 is a potent and specific myeloid differentiation protein 2 (MD2) inhibitor and inhibits the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 is used for the research of sepsis or lung injury treatment .
1
Category:
Cardiovascular Disease Neurological Disease Plants Solanaceae Extract Infection Alkaloids Capsicum annuum L. Other Alkaloids Disease Research Fields Inflammation/Immunology
Target:
1
1
1 Cited Publications
Cat. No.: HY-N6612A
CAS No.: 207300-70-7
1
1 Cited Publications
Cat. No.: HY-N2830
CAS No.: 21499-24-1
1
1 Cited Publications
Cat. No.: HY-N0320
CAS No.: 142998-47-8
1
1
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
