442 Results for "

Chinese hamster ovary/HPRT

" in MedChemExpress (MCE) Product Catalog:
Products (442)

442 Results for "Chinese hamster ovary/HPRT" in MCE Product Catalog:

387
Dimethyl sulfoxide, meets analytical specification of Ch.P.
Dimethyl sulfoxide, meets analytical specification of Ch.P.
0 Images
387 Publications Verification
Cat. No.: HY-Y0320
CAS No.: 67-68-5
Synonyms: DMSO, meets analytical specification of Ch.P.
Dimethyl sulfoxide (DMSO), meets analytical specification of Ch.P. is an aprotic solvent that dissolves polar and non-polar compounds, including water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and can rapidly penetrate or enhance the penetration of other substances into biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Dimethyl sulfoxide also exhibits antifreeze and antibacterial properties .
MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch.P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition). Amicrobic, low endotoxin, can be used in various biochemical experiments such as drug dissolution.
loading...
    loading...
View All Sizes
80
Berberine sulfate
Berberine sulfate
0 Images
80 Cited Publications
Cat. No.: HY-N0716B
CAS No.: 633-66-9
Synonyms: Natural Yellow 18 sulfate
Category:  

Alkaloids Coptis chinensis Franch. Plants Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology Ranunculaceae Extract

Target:  

Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Parasite Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB

Berberine sulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine sulfate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine sulfate has antineoplastic properties. The sulfate form improves bioavailability .
loading...
    loading...
View All Sizes
74
Shikonin
Shikonin
0 Images
74 Cited Publications
Cat. No.: HY-N0822
CAS No.: 517-89-5
Synonyms: C.I. 75535; Isoarnebin 4
Category:  

Quinones Boraginaceae Extract Plants Lithospermum erythrorhizon Sieb. et Zucc. Disease Research Fields Naphthalene Quinones Cancer

Target:  

Exosomes Chloride Channel Pyruvate Kinase NF-κB TNF Receptor HIV AIM2

Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM . Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway . Shikonin decreases exosome secretion through the inhibition of glycolysis . Shikonin inhibits AIM2 inflammasome activation .
loading...
    loading...
View All Sizes
54
Berberine hemisulfate
Berberine hemisulfate
0 Images
54 Cited Publications
Cat. No.: HY-N0716A
CAS No.: 316-41-6
Synonyms: Natural Yellow 18 hemisulfate
Category:  

Infection Alkaloids Coptis chinensis Franch. Metabolic Disease Plants Disease Research Fields Isoquinoline Alkaloids Cancer Ranunculaceae Extract

Target:  

Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB

Berberine hemisulfate is the hemisulfate form of Berberine (HY-N0716). Berberine hemisulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian. Berberine hemisulfate exhibits anti-inflammatory, antibiobic, antitumor, cardiovascular protective and neuroprotective activity .
loading...
    loading...
View All Sizes
26
Salvianolic acid B
Salvianolic acid B
0 Images
26 Cited Publications
Cat. No.: HY-N1362
CAS No.: 121521-90-2
Synonyms: Lithospermic acid B
Category:  

Cardiovascular Disease Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants Disease Research Fields Labiatae Extract

Target:  

Autophagy

Salvianolic acid B is an active ingredient of Salvia miltiorrhiza, which has been widely applied in China for the management of various microcirculation-related disorders, such as cardiovascular disease, cerebrovascular disease, and diabetic vascular complication.
loading...
    loading...
View All Sizes
21
Isorhamnetin
Isorhamnetin
0 Images
21 Cited Publications
Cat. No.: HY-N0776
CAS No.: 480-19-3
Synonyms: 3'-Methylquercetin
Category:  

Cardiovascular Disease Flavonols Hippophaë rhamnoides Leguminosae Extract Plants Endogenous metabolite Flavonoids Microorganisms Elaeagnaceae Extract Phenols Polyphenols Disease Research Fields Glycyrrhiza uralensis Fisch. Inflammation/Immunology

Target:  

MEK PI3K Endogenous Metabolite

Isorhamnetin is a flavonoid compound extracted from the Chinese herb Hippophae rhamnoides L.. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3K.
loading...
    loading...
View All Sizes
19
Gastrodin
Gastrodin
0 Images
19 Cited Publications
Cat. No.: HY-N0115
CAS No.: 62499-27-8
Synonyms: Gastrodine
Category:  

Natural Products Neurological Disease Orchidaceae Extract Gastrodia elata Bl. Anti-aging Phenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis Ferroptosis

Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin inhibits ethanol-induced hepatocellular apoptosis. Gastrodin inhibits H2O2-induced ferroptosis through its antioxidative effect. Gastrodin can be used for study of dizziness, epilepsy, stroke and dementia .
loading...
    loading...
View All Sizes
16
Polydatin
Polydatin
0 Images
16 Cited Publications
Cat. No.: HY-N0120A
CAS No.: 27208-80-6
Synonyms: Piceid
Category:  

Anti-aging Reynoutria japonica Houtt. Plants Polygonaceae Extract Stilbenes Phenols Polyphenols Disease Research Fields Inflammation/Immunology Cancer

Target:  

Autophagy Apoptosis Mitophagy

Polydatin (Piceid), extracted from the roots of Reynoutria japonica, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. Polydatin (Piceid) inhibits G6PD and induces oxidative and ER stresses.
loading...
    loading...
View All Sizes
14
Mycophenolate mofetil hydrochloride
Mycophenolate mofetil hydrochloride
0 Images
14 Cited Publications
Cat. No.: HY-B0199A
CAS No.: 116680-01-4
Synonyms: RS 61443 hydrochloride; TM-MMF hydrochloride
Category:  

Monophenols Phenols Endogenous metabolite Disease Research Fields Cancer

Target:  

Interleukin Related

Mycophenolate mofetil (RS 61443; TM-MMF) hydrochloride is an orally active antimetabolic immunosuppressant with antiproliferative and anti-inflammatory properties. Mycophenolate mofetil hydrochloride significantly inhibits the production of B, T lymphocytes and the proliferation of smooth muscle cells by selectively blocking the de novo purine synthesis pathway. Mycophenolate mofetil hydrochloride effectively reduces adventitial inflammation, medial necrosis and intimal thickening in rat aortic allografts, and decreases the number of lymphocytes expressing the IL-2 receptor, thereby delaying xenograft rejection. Mycophenolate mofetil hydrochloride shows certain toxicity in a hamster-to-rat limb xenotransplantation model when used in combination with FK506 (HY-13756). Mycophenolate mofetil hydrochloride is widely used in studies related to allograft arteriosclerosis (chronic rejection) .
loading...
    loading...
View All Sizes
12
Coptisine chloride
Coptisine chloride
0 Images
12 Cited Publications
Cat. No.: HY-N0736
CAS No.: 6020-18-4
Category:  

Infection Alkaloids Coptis chinensis Franch. Metabolic Disease Plants Disease Research Fields Isoquinoline Alkaloids Ranunculaceae Extract

Target:  

Indoleamine 2,3-Dioxygenase (IDO) Bacterial Influenza Virus

Coptisine chloride is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM. Coptisine chloride is a potent H1N1 neuraminidase (NA-1) inhibitor with an IC50 of 104.6?μg/mL and can be used for influenza A (H1N1) infection.
loading...
    loading...
View All Sizes
12
Higenamine
Higenamine
0 Images
12 Cited Publications
Cat. No.: HY-N2037
CAS No.: 5843-65-2
Synonyms: Norcoclaurine; Demethyl-Coclaurine
Category:  

Alkaloids Phenols Polyphenols  Aconitum carmichaeli Debx. Plants Disease Research Fields Isoquinoline Alkaloids Endocrinology Ranunculaceae Extract

Target:  

MAP3K MDM-2/p53 Adrenergic Receptor ROS Kinase Apoptosis

Higenamine (Norcoclaurine), a β2-AR agonist with antioxidant capability, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine is also a α1-adrenergic receptor antagonist with hypotensive effect. is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine protects myocyte Apoptosis and ischemia/reperfusion (I/R) injury through selective activation of beta2-adrenergic receptor (β2-AR). Higenamine also reduces I/R-induced myocardial infarction in mice. Higenamine can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine can be used to study cancer, inflammation, cardiorenal syndrome and other diseases .
loading...
    loading...
View All Sizes
11
Physcion
Physcion
0 Images
11 Cited Publications
Cat. No.: HY-N0108
CAS No.: 521-61-9
Synonyms: Parietin; Rheochrysidin
Category:  

Marine natural products Plants Polygonaceae Extract Biological Pesticide Research Agricultural Research Infection Quinones Microorganisms Anthraquinones Rheum officinale Baill. Phenols Polyphenols Disease Research Fields Inflammation/Immunology Marine microorganism Cancer

Target:  

Bacterial Toll-like Receptor (TLR) NF-κB Apoptosis Autophagy Antibiotic

Physcion (Parietin), an anthraquinone derivative derived from the traditional Chinese medicine rhubarb, is an effective oral active 6-phosphogluconate dehydrogenase inhibitor with blood-brain barrier permeability, with IC50 and Kd values of 38.5 μM and 26.0 μM, respectively. Additionally, Physcion is an inhibitor of the <>bTLR4/NF-κB signaling pathway, exhibiting anti-inflammatory, antibacterial, and anticancer effects, and can induce Apoptosis and Autophagy in cancer cells .
loading...
    loading...
View All Sizes
9
Stachydrine
Stachydrine
0 Images
9 Cited Publications
Cat. No.: HY-N0298
CAS No.: 471-87-4
Category:  

Alkaloids Erythrophleum fordii Oliv. Pyrrole Alkaloids Plants Endogenous metabolite Disease Research Fields Cancer Labiatae Extract

Target:  

NF-κB Endogenous Metabolite

Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway.
loading...
    loading...
View All Sizes
9
Echinatin
Echinatin
0 Images
9 Cited Publications
Cat. No.: HY-N0269
CAS No.: 34221-41-5
Category:  

Flavonoids Chalcones Phenols Polyphenols Leguminosae Extract Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Inflammation/Immunology

Target:  

Apoptosis Autophagy NOD-like Receptor (NLR)

Echinatin is a chalcone isolated from the Chinese herbal medicine Gancao with hepatoprotective and anti-inflammatory effects . Echinatin can be quickly absorbed and eliminated and extensively distributed with an absolute bioavailability of approximately 6.81% in Rat .
loading...
    loading...
View All Sizes
9
Forsythoside B
Forsythoside B
0 Images
9 Cited Publications
Cat. No.: HY-N0029
CAS No.: 81525-13-5
Category:  

Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plants Forsythia suspensa (Thunb.) Vahl Oleaceae Extract Disease Research Fields Inflammation/Immunology

Target:  

TNF Receptor NF-κB

Forsythoside B is a phenylethanoid glycoside isolated from Forsythia suspensa (Thunb.) Vahl, a Chinese folk medicinal plant for treating inflammatory diseases and promoting blood circulation. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate NF-κB.
loading...
    loading...
View All Sizes
8
Homoplantaginin
Homoplantaginin
0 Images
8 Cited Publications
Cat. No.: HY-N1949
CAS No.: 17680-84-1
Category:  

Flavonoids Flavones Cassia Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Labiatae Extract

Target:  

Free Radical Scavengers TNF Receptor NF-κB

Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinflammatory and antioxidant properties. Homoplantaginin could inhibit TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation.
loading...
    loading...
View All Sizes
8
Schaftoside
Schaftoside
0 Images
8 Cited Publications
Cat. No.: HY-N0703
CAS No.: 51938-32-0
Category:  

Flavonoids Eleusine indica (Linn.) Gaertn. Flavones Leguminosae Extract Plants Gramineae Extract Disease Research Fields Glycyrrhiza uralensis Fisch. Inflammation/Immunology

Target:  

Toll-like Receptor (TLR) MyD88 Dynamin Mitochondrial Metabolism Autophagy

Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission .
loading...
    loading...
View All Sizes
8
Aloperine
Aloperine
0 Images
8 Cited Publications
Cat. No.: HY-13516
CAS No.: 56293-29-9
Purity:  ≥98.0%
Category:  

Infection Alkaloids Piperidine Alkaloids Sophora alopecuroides L Leguminosae Extract Plants Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis Autophagy Filovirus HIV

Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties . Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China . Aloperine induces apoptosis and autophagy in HL-60 cells .
loading...
    loading...
View All Sizes
7
Oroxin B
Oroxin B
0 Images
7 Cited Publications
Cat. No.: HY-N1435
CAS No.: 114482-86-9
Category:  

Flavonoids Flavones Phenols Polyphenols Plants Bignoniaceae Extract Oroxylum indicum (Linn.) Bentham ex Kurz Disease Research Fields Cancer

Target:  

Apoptosis PI3K PTEN Autophagy

Oroxin B (OB) is a BBB-permeable flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent. Oroxin B (OB) possesses obvious inhibitory effect and induces early apoptosis rather than late apoptosis on liver cancer cells through upregulation of PTEN, down regulation of COX-2, VEGF, PI3K, and p-AKT. Oroxin B (OB) selectively induces tumor-suppressive ER stress in malignant lymphoma cells .
loading...
    loading...
View All Sizes
6
Rofecoxib
Rofecoxib
0 Images
6 Cited Publications
Cat. No.: HY-17372
CAS No.: 162011-90-7
Synonyms: MK 966
Target:  

COX

Research Areas:  

Inflammation/Immunology Cancer

Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells).
loading...
    loading...
View All Sizes
Assay Types