248 Results for "

anti-diabetic activities

" in MedChemExpress (MCE) Product Catalog:

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Glycyrrhizic acid

67 Publications Verification

Cat. No.: HY-N0184

CAS No.: 1405-86-3

Synonyms: Glycyrrhizin

Category:

Triterpenes Terpenoids Metabolic Disease Leguminosae Extract Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Sweeteners Food Research

Target:

Virus Protease

Glycyrrhizic acid is a triterpenoid saponinl, acting as a direct HMGB1 antagonist, with anti-tumor, anti-diabetic activities.

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Rutin trihydrate

35 Cited Publications

Cat. No.: HY-W013075

CAS No.: 250249-75-3

Synonyms: Rutoside trihydrate; Quercetin 3-O-rutinoside trihydrate

Category:

Flavonoids Combretaceae Extract Flavones Combretum micranthum G. Don Plants

Target:

Apoptosis Endogenous Metabolite

Rutin (Rutoside) trihydrate is a multifunctional natural flavonoid glycoside. Rutin trihydrate has been demonstrating excellent antioxidant, anti-inflammatory, anti-diabetic, and anti-carcinogenic properties. Cardioprotective and neuroprotective activities .

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Rutin hydrate

35 Cited Publications

Cat. No.: HY-N0148A

CAS No.: 207671-50-9

Synonyms: Rutoside hydrate; Quercetin 3-O-rutinoside hydrate

Category:

Flavonols Flavonoids Phenols Polyphenols Plants Other Families Extract

Target:

Amyloid-β Autophagy Apoptosis Endogenous Metabolite

Rutin (Rutoside) hydrate is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin hydrate can cross the blood brain barrier. Rutin hydrate attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .

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Rutin

35 Cited Publications

Cat. No.: HY-N0148

CAS No.: 153-18-4

Synonyms: Rutoside; Quercetin 3-O-rutinoside

Category:

Flavonols Leguminosae Extract Plants Other Families Extract Flavonoids Sunscreen Phenols Polyphenols Cosmetic Research Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer

Target:

Amyloid-β Autophagy Apoptosis Endogenous Metabolite

Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a CBR1 inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress .

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Myricetin

30 Cited Publications

Cat. No.: HY-15097

CAS No.: 529-44-2

Purity: 98.42%

Synonyms: Cannabiscetin

Category:

Flavonols Anti-aging Plants Endogenous metabolite Human Gut Microbiota Metabolites Myricaceae Extract Flavonoids Microorganisms Sunscreen Myrica nagi Cosmetic Research Disease Research Fields Cancer

Target:

PI3K Apoptosis Autophagy Endogenous Metabolite

Myricetin is a common plant-derived flavonoid with a wide range of activities including strong anti-oxidant, anticancer, antidiabetic and anti-inflammatory activities.

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Beta-Sitosterol (purity>80%)

25 Cited Publications

Cat. No.: HY-N0171

CAS No.: 83-46-5

Category:

Endogenous metabolite

Target:

Apoptosis Endogenous Metabolite

Beta-Sitosterol (purity≥80%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc .

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Beta-Sitosterol (purity>98%)

25 Cited Publications

Cat. No.: HY-N0171A

CAS No.: 83-46-5

Synonyms: β-Sitosterol (purity>98%); 22,23-Dihydrostigmasterol (purity>98%)

Category:

Steroids

Target:

Bacterial Apoptosis Reactive Oxygen Species (ROS) MDM-2/p53 Caspase PARP MMP Bcl-2 Family HIF/HIF Prolyl-Hydroxylase TNF Receptor Interleukin Related NF-κB mTOR Lactate Dehydrogenase CDK Glutathione Peroxidase SOD

Beta-Sitosterol (purity>98%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc .

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Geniposide

20 Cited Publications

Cat. No.: HY-N0009

CAS No.: 24512-63-8

Category:

Iridoids Terpenoids Plants Gardenia jasminoides Ellis Rubiaceae Extract

Target:

Amyloid-β Influenza Virus

Geniposide is an iridoid glucoside extracted from Gardenia jasminoidesEllis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities.

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Cardamonin

19 Cited Publications

Cat. No.: HY-N0279

CAS No.: 18956-16-6

Synonyms: Cardamomin; Alpinetin chalcone

Category:

Flavonoids Chalcones Zingiberaceae Extract Boesenbergia rotunda Phenols Polyphenols Plants Disease Research Fields Cancer

Target:

NF-κB STAT Wnt β-catenin Bcl-2 Family Apoptosis

Cardamonin can be found from cardamom, and can target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities .

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Mangiferin

16 Cited Publications

Cat. No.: HY-N0290

CAS No.: 4773-96-0

Category:

Xanthones Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants Liliaceae Extract Disease Research Fields Cancer

Target:

NF-κB Keap1-Nrf2 Apoptosis

Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities .

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Piperlongumine

16 Cited Publications

Cat. No.: HY-N2329

CAS No.: 20069-09-4

Synonyms: Piplartine

Category:

Cardiovascular Disease Infection Piper longum Linn. Alkaloids Piperaceae Extract Pyridine Alkaloids Plants Disease Research Fields

Target:

ERK Reactive Oxygen Species (ROS) Autophagy Apoptosis Bacterial Ferroptosis

Piperlongumine is a alkaloid , possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities . Piperlongumine induces ROS, and induces apoptosis in cancer cell lines . Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway. Piperlongumin could be used in the study of migrasome .

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Fucoxanthin

15 Cited Publications

Cat. No.: HY-N2302

CAS No.: 3351-86-8

Synonyms: all-trans-Fucoxanthin

Category:

Natural Products Anti-aging Whitening Agent Marine natural products Metabolic Disease Plants Other Families Extract Food Research Sunscreen Marine algae Pigments Cosmetic Research Disease Research Fields Inflammation/Immunology Cancer

Target:

Bacterial PPAR c-Myc NO Synthase Caspase ERK

Fucoxanthin (all-trans-Fucoxanthin) is a marine carotenoid and shows anti-obesity, anti-diabetic, anti-oxidant, anti-inflammatory and anticancer activities .

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Glabridin

13 Cited Publications

Cat. No.: HY-N0393

CAS No.: 59870-68-7

Category:

Leguminosae Extract Plants Infection Flavonoids Phenols Polyphenols Disease Research Fields Glycyrrhiza uralensis Fisch. Inflammation/Immunology Isoflavones

Target:

PPAR Reactive Oxygen Species (ROS) Bacterial

Glabridin is a natural isoflavan from Glycyrrhiza glabra L., binds to and activates PPARγ, with an EC₅₀ of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities .

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Pterostilbene

12 Cited Publications

Cat. No.: HY-N0828

CAS No.: 537-42-8

Category:

Monophenols Stilbenes Phenols Plants Other Families Extract Disease Research Fields Inflammation/Immunology

Target:

Free Radical Scavengers Autophagy

Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium . Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties . Pterostilbene blocks ROS production , also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide .

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Trigonelline

10 Cited Publications

Cat. No.: HY-N0414

CAS No.: 535-83-1

Synonyms: Trigenolline

Category:

Pyridine Alkaloids Metabolic Disease Leguminosae Extract Plants Other Families Extract Endogenous metabolite Alkaloids Microorganisms Disease Research Fields Trigonella foenum-graecum Linn.

Target:

Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal

Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.

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Trigonelline chloride

10 Cited Publications

Cat. No.: HY-N0415

CAS No.: 6138-41-6

Synonyms: Trigonelline hydrochloride

Category:

Infection Alkaloids Erythrophleum fordii Oliv. Pyridine Alkaloids Metabolic Disease Plants Disease Research Fields Labiatae Extract

Target:

Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal

Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.

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Kaempferide

7 Cited Publications

Cat. No.: HY-15449

CAS No.: 491-54-3

Purity: 99.80%

Synonyms: Kaempferol 4'-O-methyl ether

Category:

Infection Flavonols Flavonoids Zingiberaceae Extract Phenols Polyphenols Alpinia officinarum Hance Plants Disease Research Fields

Target:

Estrogen Receptor/ERR Autophagy Bacterial Influenza Virus Apoptosis PI3K Akt GSK-3 FOXO β-catenin

Kaempferide is an orally active flavonol isolated from Hippophae rhamnoides L. Kaempferide has anticancer, anti-inflammatory, antioxidant, antidiabetic, antiobesity, antihypertensive, and neuroprotective activities. Kaempferide induces apoptosis. Kaempferide promotes osteogenesis through antioxidants and can be used in osteoporosis research .

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Azoramide

7 Cited Publications

Cat. No.: HY-18705

CAS No.: 932986-18-0

Target:

Apoptosis Reactive Oxygen Species (ROS) Caspase Bcl-2 Family Mitochondrial Metabolism

Research Areas:

Endocrinology

Azoramide is a potent, orally active small-molecule modulator of the unfolded protein response (UPR). Azoramide improves ER protein folding and elevates ER chaperone capacity, which together protects cells against ER stress. Azoramide alleviates PLA2G6 mutant-induced ER stress through modulating unfolded protein response, and enhances the CERB signaling to rescue mitochondrial function, thereby preventing apoptosis of DA neurons. Azoramide has antidiabetic activity .

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Sinapinic acid

5 Cited Publications

Cat. No.: HY-W009732

CAS No.: 530-59-6

Synonyms: Sinapic acid

Category:

Monophenols Simple Phenylpropanols Metabolic Disease Phenols Phenylpropanoids Plants Other Families Extract Disease Research Fields

Target:

HDAC Angiotensin-converting Enzyme (ACE) Reactive Oxygen Species (ROS) Apoptosis

Sinapinic acid (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack. Rhizome, acts as an inhibitor of HDAC, with an IC₅₀ of 2.27 mM , and also inhibits ACE-I activity . Sinapinic acid posssess potent anti-tumor activity, induces apoptosis of tumor cells . Sinapinic acid shows antioxidant and antidiabetic activities . Sinapinic acid reduces total cholesterol, triglyceride, and HOMA-IR index, and also normalizes some serum parameters of antioxidative abilities and oxidative damage in ovariectomized rats .

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Loureirin B

4 Cited Publications

Cat. No.: HY-N1504

CAS No.: 119425-90-0

Category:

Dracaena cochinchinensis (Lour.) S. C. Chen Flavonoids Monophenols Metabolic Disease Phenols Agavaceae Extract Plants Dihydrochalcones Disease Research Fields

Target:

PAI-1 Potassium Channel ERK JNK

Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC₅₀ of 26.10 μM; Loureirin B also inhibits K_ATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.

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