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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2015 Results for "
hydroxy
" in MedChemExpress (MCE) Product Catalog:
Products (2015)
2015 Results for "hydroxy" in MCE Product Catalog:
69
69 Publications Verification
Cat. No.: HY-17379
CAS No.: 134523-03-8
Synonyms: CI-981; Atorvastatin hemicalcium
Research Areas:
Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, with blood-brain barrier permeability. Atorvastatin hemicalcium salt has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium salt inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively .
30
28
28 Cited Publications
Synonyms: 4-hydroxy-TEMPO
Research Areas:
Tempol is a general superoxide dismutase (SOD)-mimetic agent that efficiently neutralizes reactive oxygen species (ROS).
24
24 Cited Publications
Cat. No.: HY-Y1893
CAS No.: 61909-81-7
Synonyms: Polyethylene glycol 12-hydroxystearate
21
Category:
Human Gut Microbiota Metabolites Anti-aging Metabolic Disease Endogenous metabolite Disease Research Fields Steroids
Target:
18
Target:
Research Areas:
Hydroxy Dynasore (Dyngo-4a), a structural mimetic analog of Dynasore (HY-15304), is an improved, less cytotoxic and versatile dynamin inhibitor with IC50 values of 0.38 μM and 2.3 μM for brain recombinant dynamin I and recombinant mouse dynamin II, respectively. Hydroxy Dynasore inhibits dynamin-dependent transferrin endocytosis with an IC50 of 5.7 μM.
18
18 Cited Publications
Cat. No.: HY-P81208
Synonyms: 4-hydroxy-2-Nonenal; 4hydroxynonenal; 4-hydroxynonenal; HNE; 4HNE; 4-HNE; (E)-4-hydroxy-2-nonenal; 2-Nonenal, 4-hydroxy-, (2E)-; (2E)-4-hydroxy-2-nonenal; 4-hydroxy-2(E)-nonenal
17
17 Cited Publications
Cat. No.: HY-P81140
Synonyms: 8-hydroxy-2'-deoxyguanosine; 2'-Deoxy-8-oxoguanosine; 7,8-Dihydro-8-oxo-2'-deoxyguanosine; 8-Oxo-7,8-dihydro-2'-deoxyguanosine; 8-Oxo-7,8-dihydrodeoxyguanosine; 2'-Deoxy-8-oxo-D-guanosine; 8-Oxo-7,8-dihydro-2μ-deoxyguanosine,8-Oxo-dG; 2'-Deoxy-8-hydroxyguanosine;
16
Target:
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
14
Category:
Natural Products Other disease Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields
Target:
14
14 Cited Publications
Cat. No.: HY-32351A
CAS No.: 63283-36-3
Synonyms: 25-hydroxy Vitamin D3 monohydrate
Target:
11
11 Cited Publications
Synonyms: 17α-hydroxy-6α-methylprogesterone; U8840
Target:
Research Areas:
Medroxyprogesterone (17α-Hydroxy-6α-methylprogesterone) is a synthetic human variant of progesterone that is a progesterone receptor agonist with oral activity. Medroxyprogesterone can induce cell proliferation through the PI3K/Akt signaling pathway. Medroxyprogesterone has an inhibitory effect on atherosclerosis in mice. The progesterone agonist activity of Medroxyprogesterone is less effective than Medroxyprogesterone acetate (HY-B0469) .
9
9 Cited Publications
Synonyms: 8-hydroxy-DPAT hydrobromide
Target:
Research Areas:
8-OH-DPAT (8-Hydroxy-DPAT) hydrobromide is a potent, brain-penetrant and selective 5-HT1A agonist with a pIC50 of 8.19. 8-OH-DPAT hydrobromide has selectivity of almost 1000 fold for a subtype of the 5-HT1 binding site .
9
9 Cited Publications
Synonyms: 8-hydroxy-DPAT
Target:
Research Areas:
8-OH-DPAT is a potent, brain-penetrant and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5).
8
8 Cited Publications
Synonyms: HOSu; 1-hydroxy-2,5-pyrrolidinedione
8
8 Cited Publications
Cat. No.: HY-W018512
CAS No.: 4651-67-6
Synonyms: 3α-hydroxy-7-oxo-5β-cholanic acid
Target:
8
Target:
PCSK9 Small Interfering RNA (siRNA) Pyroptosis PPAR NOD-like Receptor (NLR) Caspase Interleukin Related
Research Areas:
Inclisiran is a double-stranded small interfering RNA (siRNA) molecule. Inclisiran inhibits the transcription of PCSK9. Inclisiran inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, IL-1β, and IL-18. Inclisiran has anti-inflammatory, lipid-regulating and anti-atherosclerotic activities. Inclisiran can be used in researches of hyperlipidemia and cardiovascular disease (CVD) .
7
Category:
Target:
7
7
7 Cited Publications
Synonyms: 3β-hydroxy-5-pregnen-20-one monosulfate sodium
Category:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
