Drug Isomer
Drug Isomer
Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.
References:
- [1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [Content Brief]
- [2]. Andersson T. Single-isomer drugs: true therapeutic advances. Clin Pharmacokinet. 2004;43(5):279-85. [Content Brief]
- [3]. Chhabra N, et al. A review of drug isomerism and its significance. Int J Appl Basic Med Res. 2013 Jan;3(1):16-8. [Content Brief]
All Product Categories
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Drug Isomer Related Products (557)
Related Products (557)
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trans-Cefprozil
0 ImagesCat. No.: HY-B0458BCAS No.: 92676-86-3trans-Cefprozil is a trans-isomer of Cefprozil (HY-B0458A). Cefprozil is a cephalosporin Antibiotic. trans-Cefprozil exhibits antibacterial activity. The antibacterial activity of trans-Cefprozil against Gram-positive bacteria is similar to that of cis-Cefprozil, but its activity against Gram-negative bacteria is lower than that of cis-Cefprozil. trans-Cefprozil can be used for research on Staphylococcus aureus and Escherichia coli infections.
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(+)-Theta-cypermethrin
0 ImagesCat. No.: HY-W714853CAS No.: 65732-07-2(+)-Theta-cypermethrin is a stereoisomer of Cypermethrin (HY-B0829) that possesses blood-brain barrier penetration ability and binds to AKT1, SRC, STAT3 and EGFR with high affinity. (+)-Theta-cypermethrin reduces the amplitude of delayed rectifier potassium channel currents, shifts the steady-state activation curve to negative potentials, and shifts the steady-state inactivation curve to negative potentials at higher concentrations. (+)-Theta-cypermethrin induces abnormal electrical activity in rat hippocampal neurons. (+)-Theta-cypermethrin causes chronic respiratory system damage and exhibits neurotoxicity.
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ent-25-Hydroxycholesterol
0 ImagesCat. No.: HY-N15915CAS No.: 915159-32-9ent-25-Hydroxycholesterol is an enantiomer of 25-Hydroxycholesterol (HY-113134).
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(R)-Balcinrenone
0 ImagesSynonyms: (R)-AZD9977(R)-Balcinrenone ((R)-AZD9977) is an isomer of Balcinrenone (HY-120274). Balcinrenone is an orally active mineralocorticoid receptor modulator. Balcinrenone regulates mineralocorticoid receptor activity, inhibits aldosterone-induced target gene expression, and suppresses the activities of renal Toll-like receptor 4, MyD88 and NF-κB. Balcinrenone alleviates renal extracellular matrix remodeling, inflammatory cell infiltration, and the expression of renal injury markers. Balcinrenone restores myocardial perfusion reserve, regulates potassium homeostasis, and induces fecal potassium excretion. Balcinrenone is applicable to research on metabolism-related chronic kidney disease and heart failure.
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(R)-Bemcentinib
0 ImagesCat. No.: HY-15150CCAS No.: 1037624-76-2Synonyms: (R)-R428; (R)-BGB324(R)-Bemcentinib ((R)-R428) is the R-isomer of Bemcentinib (HY-15150). Bemcentinib (R428) is a selective, orally active Axl inhibitor with an IC50 of 14 nM. Bemcentinib blocks tumor metastasis and prolongs survival in metastatic breast cancer models.
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1,2-Dimyristoyl-3-eicosapentaenoyl-rac-glycerol
0 ImagesCat. No.: HY-165037CAS No.: 116198-40-4Synonyms: MME; 1,2-Myristin-3-eicosapentaenoin; 14:0/14:0/20:5-TG1,2-Dimyristoyl-3-eicosapentaenoyl-rac-glycerol (MME) is a compound that is studied as a triglyceride isomer in algae, and its isomer ratio changes with culture temperature.
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2-Methylethcathinone hydrochloride
0 ImagesCat. No.: HY-W719019ACAS No.: 2705355-07-1Synonyms: 2-MEC hydrochloride2-Methylethcathinone (2-MEC) is an isomer of a psychoactive substance.
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(R)-L 888607
0 Images(R)-L 888607 is the isomer of L 888607 (HY-111271), and can be used as an experimental control. L 888607 is a potent, selective, stable and orally active CRTH2 agonist. L 888607 has high affinity for the human CRTH2 receptor with a Ki value of 4 nM. L 888607 can be used for the research of several physiological events and metabolite.
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(Rac)-Lonafarnib
0 ImagesCat. No.: HY-15136BCAS No.: 193275-86-4Synonyms: Sch66336 racemate(Rac)-Lonafarnib (Sch66336 racemate) is an isomer of Lonafarnib (HY-15136). Lonafarnib (Sch66336) is an orally active, blood-brain barrier penetrant farnesyltransferase (FPTase) inhibitor. Lonafarnib increases the phosphorylation levels of Akt, CaMKII and CREB, upregulates BDNF expression in the hippocampus, elevates the content of α7nAChR on cell membranes, and blocks the isoprenylation of H-Ras. Lonafarnib repairs synapses and reverses spatial memory deficits in Aβ1-42 model mice. Lonafarnib inhibits RSV fusion and replication, and alleviates virus-induced lung injury. Lonafarnib activates the lysosomal and autophagic pathways, and reduces the phosphorylation and aggregation of tau. Lonafarnib acts synergistically with Sorafenib (HY-10201) to promote apoptosis, and inhibits the proliferation and invasion of melanoma cells. Lonafarnib inhibits the farnesylation of progerin, repairs nuclear membrane defects, and activates the cGAS-STING-STAT1 signaling pathway. Lonafarnib can be used in research related to diseases including Alzheimer's disease, viral infections, melanoma, and progeria.
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NSC 23925B
0 ImagesCat. No.: HY-117593CAS No.: 1369591-04-7NSC 23925B is a P-glycoprotein (P-gp) inhibitor, as well as the most biologically active isomer of NSC23925 (HY-19626), which reverses and prevents P-glycoprotein-mediated multidrug resistance in cancer cells. NSC 23925B shows weak inhibition against most CYP450 enzymes (IC50 > 10 μM), and exhibits moderate inhibitory activity against CYP2B6 and CYP2D6 with IC50 values of 8.589 μM and 1.407 μM, respectively. NSC 23925B can be used for the research of multidrug-resistant cancers.
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(-)-Umtatin
0 ImagesCat. No.: HY-N16536CAS No.: 17398-06-0(-)-umtatin is a chiral furochromone. (-)-umtatin can be isolated from Ptaeroxylon obliquum (Meliaceae).
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(S)-3-N-Cbz-Amino-succinimide
0 ImagesCat. No.: HY-W097106CAS No.: 60846-91-5(S)-3-N-Cbz-Amino-succinimide (Compound 1d) is an antiepileptic agent that can inhibit pentylenetetrazole (PTZ) and maximal electroshock (MES)-induced tonic convulsions in mice.
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Tauroursocholic acid sodium
0 ImagesCat. No.: HY-201296ACAS No.: 17515-36-5Synonyms: TUCA sodiumTauroursocholic acid (TUCA) sodium is a taurine-conjugated form of the bile acid ursocholic acid and the 7β-hydroxy epimer of Taurocholic acid (HY-B1788). Tauroursocholic acid sodium exists in abundance during the biliary tract cancer, disrupting the balance and cellular toxicity of bile acids and inducing carcinogenesis through oxidative DNA damage and DNA mutation. Tauroursocholic acid (TUCA) sodium can be used for biliary tract cancer research.
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(S)-Mansonone E
0 Images(S)-Mansonone E is the S-configurational form of Mansonone E (HY-118401). Mansonone E acts as an insecticide.
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(S)-ML399
0 Images(S)-ML399 (Compound 18S) is the enantiomer of ML399 (HY-117948). (S)-ML399 acts as a Menin-MLL interaction inhibitor with an IC50 of 1400 nM. (S)-ML399 can be used to investigate acute leukemias with MLL translocations, including acute myeloid leukemia and acute lymphoblastic leukemia.
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(-)-Salcolin B
0 ImagesCat. No.: HY-N21550CAS No.: 1292294-32-6Synonyms: Tricin 4'-O-(threo-β-guaiacylglyceryl)ether(-)-Salcolin B (Tricin 4'-O-(threo-β-guaiacylglyceryl) ether) is an isomer of Salcolin B (HY-N16766) and anti-inflammatory agent. (-)-Salcolin B is isolable from Njavara. (-)-Salcolin B downregulates the activities of NF-κB and STAT3, reduces the expressions of iNOS and COX-2, activates the ERK signaling pathway, and inhibits LPS-induced NO and ROS production. (-)-Salcolin B induces Apoptosis. (-)-Salcolin B inhibits TPA (HY-18739)-induced ear edema. (-)-Salcolin B possesses antioxidant activity. (-)-Salcolin B can be used in research related to inflammatory diseases, colon adenocarcinoma, ovarian cancer and breast cancer.
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(S,S,S)-AHPC-PEG2-NH2
0 ImagesCat. No.: HY-103603CCAS No.: 3049082-35-8(S,S,S)-AHPC-PEG2-NH2 is an isomer of Compound 15b. Compound 15b is a conjugate of a VHL ligand and linker. Compound 15b can be used to synthesize PROTAC. Compound 15b can be used in leukemia research.
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(±)-Dihydroactinidiolide (Standard)
0 Images(±)-Dihydroactinidiolide (Standard) is the analytical standard of (±)-Dihydroactinidiolide (HY-W041301). This product is intended for research and analytical applications. (±)-Dihydroactinidiolide is the dextrorotatory form of Dihydroactinidiolide (HY-107805). (±)-Dihydroactinidiolide has a strong, pleasant musky, tea-like and tobacco-like aroma and is mainly found in black tea, tobacco and fruits. (±)-Dihydroactinidiolide has antioxidant activity and can be derived from β-carotene.
