Art. -Nr.: HY-W017462

Creatine monohydrate

6 Cited Publications

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Based on 6 publication(s) in Google Scholar

Creatine monohydrate, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain.

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Reinheit: 99.98%
CAS. Nr.: 6020-87-7
Formel: C₄H₁₁N₃O₃
Molecular Weight:149.15

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Creatine monohydrate Chemical Structure

CAS. Nr.: 6020-87-7

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (6)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Creatine monohydrate, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain^[1].

IC₅₀ & Target

Human Endogenous Metabolite

Microbial Metabolite

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

Alle PI3K Isoform-spezifische Produkte anzeigen :

Alle Akt Isoform-spezifische Produkte anzeigen :

In Vitro

Creatine monohydrate (10-20 mM, 1-3 weeks) promotes the cell growth, differentiation and mineralization of osteoblast-like cells^[2].
Creatine monohydrate (0.1-10 mM, 2-24 h) scanvages the free radicals, protects the DNA especially mtDNA from oxidative damage^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Creatine monohydrate (0.1-1000 mg/kg, po, single dose) exhibits antidepressant-like activity in mouse tail suspension test, which could be enhanced by dopamine receptor agonist SKF38393 (HY-12520A) and Apomorphine (HY-12723)^[4].
Creatine monohydrate (0.03-0.3 mg/kg, drinking water for 8 weeks) stimulates the PI3K/AKT signaling pathways, promotes the protein synthesis and muscle hypertrophy, thereby promoting the performance of short-duration, high-intensity exercise in rats models^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Rats models^[5]

Dosage:

0.03-0.3 mg/kg

Administration:

drinking water for 8 weeks

Result:

Increased the perimeter and area of the soleus muscle.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 6020-87-7
Appearance Solid
Molecular Weight 149.15
Formel C₄H₁₁N₃O₃
Color White to off-white
SMILES

O=C(O)CN(C(N)=N)C.[H]O[H]
Structure Classification
- Amino acids
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (6)

All Bio/Physico-chemical AssayELISAFlow CytometryIn Vivo Efficacy Study

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Journal Impact Factor

Cell Res

Compression-induced metabolic adaptation drives confined tumor cell migration and distant metastasis via malate-dependent microtubule reinforcement. [Abstract]

2026 Jul;36(7):513-530. PMID: 42151565
Proc Natl Acad Sci U S A

Structural insights into the substrate uptake and inhibition of the human creatine transporter (hCRT). [Abstract]

2025 Sep 9;122(36):e2426135122. PMID: 40892912

Creatine monohydrate purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2025 Sep 9;122(36):e2426135122. [Abstract]

SPR analysis showed Creatine (25 μM) binding to hCRT, with a dissociation constant (K_D) of 3.2 μM.
Cancer Immunol Res

In Situ Delivery of Gasdermin E mRNA Promotes Antitumor Immunity via Creatine-Elicited Type I Interferon Signaling in Monocytes. [Abstract]

2025 Jun 4;13(6):939-956. PMID: 40168141

Creatine monohydrate purchased from MedChemExpress. Usage Cited in: Cancer Immunol Res. 2025 Jun 4;13(6):939-956. [Abstract]

Creatine (10, 100, and 1,000 µmol/L; 24 h) stimulates type I IFN induction via the cGAMP–cGAS–STING–IRF3 signaling axis. 2030-cGAMP was robustly induced in monocytes following Creatine treatment.

Creatine monohydrate purchased from MedChemExpress. Usage Cited in: Cancer Immunol Res. 2025 Jun 4;13(6):939-956. [Abstract]

Examination of cGAS-STING downstream signaling in monocytes by flow cytometry revealed activation of the STING-TBK1-IRF3 signaling axis following Creatine (10, 100, and 1,000 µmol/L; 24 h) treatment.

Creatine monohydrate purchased from MedChemExpress. Usage Cited in: Cancer Immunol Res. 2025 Jun 4;13(6):939-956. [Abstract]

Combination of LNP-Gsdme and Creatine (10.5 mg/mice; once daily; IT) synergistically suppresses tumor growth. Tumor growth curves, tumor images, and tumor weights of B16F10 and 4T1 tumor–bearing mice treated with LNP-Gsdme/GFP or combined with Creatine.
Cell Rep

SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer. [Abstract]

2025 Sep 1;44(9):116139. PMID: 40892544

Creatine monohydrate purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Sep 1;44(9):116139. [Abstract]

The syngeneic mouse MC38 CRC model was utilized to examine how Creatine (oral gavage; 50 mg/mL; 400 μL/time; 3 times per week) supplementation, with or without the addition of anti-PD-1 antibody, affected tumor growth and survival. Tumor growth, tumor weights, and survival curves were recorded for the MC38 model mice given the different therapies. Combination therapy significantly suppressed tumor growth and prolonged survival of MC38 tumor-bearing immunocompetent C57BL/6 J mice compared to either single-agent or control-treated groups.

Creatine monohydrate purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Sep 1;44(9):116139. [Abstract]

Tumor growth curve and tumor weights of DLD1 xenografts after indicated treatment.To ascertain whether Creatine (oral gavage; 50 mg/mL; 400 μL/time; 3 times per week) exhibits an inhibitory effect on tumor progression, a DLD-1 xenograft model was established, and Creatine was found to remarkably inhibit tumor development.
Toxicol Appl Pharmacol

Cytochalasin Q exerts anti-melanoma effect by inhibiting creatine kinase B. [Abstract]

2022 Apr 15:441:115971. PMID: 35276125
Connect Tissue Res

Creatine promotes osteogenic differentiation of dental pulp stem cells via the AMPK-ULK1-autophagy axis. [Abstract]

2025 Mar;66(2):73-86. PMID: 39930963

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 16.67 mg/mL (111.77 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.7047 mL

33.5233 mL

67.0466 mL

5 mM

1.3409 mL

6.7047 mL

13.4093 mL

10 mM

0.6705 mL

3.3523 mL

6.7047 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Nouioua S, et al. Creatine deficiency syndrome. A treatable myopathy due to arginine-glycine amidinotransferase (AGAT) deficiency. Neuromuscul Disord. 2013 Aug;23(8):670-4. [Content Brief]

[2]. Gerber I, et al., Stimulatory effects of creatine on metabolic activity, differentiation and mineralization of primary osteoblast-like cells in monolayer and micromass cell cultures. Eur Cell Mater. 2005 Jul 15;10:8-22. [Content Brief]

[3]. Guidi C, et al., Differential effect of creatine on oxidatively-injured mitochondrial and nuclear DNA. Biochim Biophys Acta. 2008 Jan;1780(1):16-26. [Content Brief]

[4]. Cunha MP, et al., Antidepressant-like effect of creatine in mice involves dopaminergic activation. J Psychopharmacol. 2012 Nov;26(11):1489-501. [Content Brief]

[5]. ARRUDA I F S, et al. Histological effects of Creatine monohydrate supplementation on muscle tissue in Wistar rats[J]. Modern Medicine, 2023, 30(2).

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	6.7047 mL	33.5233 mL	67.0466 mL	167.6165 mL
	5 mM	1.3409 mL	6.7047 mL	13.4093 mL	33.5233 mL
	10 mM	0.6705 mL	3.3523 mL	6.7047 mL	16.7617 mL
	15 mM	0.4470 mL	2.2349 mL	4.4698 mL	11.1744 mL
	20 mM	0.3352 mL	1.6762 mL	3.3523 mL	8.3808 mL
	25 mM	0.2682 mL	1.3409 mL	2.6819 mL	6.7047 mL
	30 mM	0.2235 mL	1.1174 mL	2.2349 mL	5.5872 mL
	40 mM	0.1676 mL	0.8381 mL	1.6762 mL	4.1904 mL
	50 mM	0.1341 mL	0.6705 mL	1.3409 mL	3.3523 mL
	60 mM	0.1117 mL	0.5587 mL	1.1174 mL	2.7936 mL
	80 mM	0.0838 mL	0.4190 mL	0.8381 mL	2.0952 mL
	100 mM	0.0670 mL	0.3352 mL	0.6705 mL	1.6762 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Creatine monohydrate

6 Cited Publications

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Creatine monohydrate

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Publications Citing Use of MedChemExpress (MCE) Creatine monohydrate

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Alle PI3K Isoform-spezifische Produkte anzeigen

Alle Akt Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information