X-370
X-370 is a PI3Kδ inhibitor (IC50 = 7 nM). X-370 inhibits the survival of leukemia cells, inducing G1 arrest and apoptosis. X-370 blocks PDK1 binding and phosphorylation of MEK1/2, eliminating Akt and Erk1/2 signaling. X-370 can be used in research on B-cell acute lymphoblastic leukemia (B-ALL).
For research use only. We do not sell to patients.
- CAS No.: 1280725-80-5
- Formula: C27H31F2N9O2
- Molecular Weight:551.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Biological Activity
Chemical Information
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CAS No. 1280725-80-5
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Molecular Weight 551.59
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Formula C27H31F2N9O2
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SMILES
FC(F)C1=NC2=C(N1C3=NC(N4CCOCC4)=NC5=C3N=CN5C6CCN(C(N7CCCC7)=O)CC6)C=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
X-370 Related Classifications
HY-12482 Related Classifications
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