Cat. No.: HY-N0236

Corylin

12 Cited Publications

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Based on 12 publication(s) in Google Scholar

Corylin is an orally active flavonoid anti-inflammatory and osteogenic agent that inhibits IL-6-induced STAT3 promoter activity and STAT3 phosphorylation. Corylin also has anticancer, antiatherosclerotic, and ameliorating activity in hyperlipidemia and insulin resistance, inducing adipocyte browning and lipolysis through SIRT1 or β3-AR-dependent pathways.

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Pureté: 99.97%
CAS No.: 53947-92-5
Formule: C₂₀H₁₆O₄
Masse moléculaire:320.34

Stockage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Corylin Chemical Structure

CAS No.: 53947-92-5

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (12)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Antibiotic :

Voir tous les produits spécifiques à Isoform STAT :

In Vitro

Corylin (3-300 µM, 0-72 h) inhibits the proliferation of HepG2 and Huh7 cells^[2].
Corylin (3-30 µM, 0-48 h) inhibits the migration and invasiveness of HepG2 and Huh7 cells by suppressing EMT^[2].
Corylin (5-200 µM, 24 h) reduces the viability of 3T3-L1 preadipocytes at the doses of 100-200 µM^[3].
Corylin (10 µM, 24 h) induces browning via the SIRT1 and β3-AR pathways in 3T3-L1 adipocytes^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

HepG2 and Huh7 cells
Concentration:

3-30 µM
Incubation Time:

24-48 h
Result:

Reduced the expression of EMT-promoting proteins such as N-cadherin, vimentin, slug, and twist.

In Vivo

Corylin (60 mg/kg, i.p., three times a week, 4 weeks) inhibits tumor growth in Huh7 cells xenograft mice^[3].
Corylin (50-100 mg/kg, p.o., daily, 9 weeks) improves the high-fat diet (HFD)-induced obesity in HFD- and DIO-treated mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

HFD- and DIO-treated mice^[3]
Dosage:

50-100 mg/kg
Administration:

Oral gavage (p.o.), daily, 9 weeks
Result:

Reduced the weight of subcutaneous, visceral WAT, and body.
Decreased the size of WAT adipocyte.
Increased insulin sensitivity, mitochondrial biogenesis, and β-oxidation.
Reduced serum levels of insulin and leptin and improved HOMA-IR.

Chemical Information

CAS No. 53947-92-5
Appearance Solid
Masse moléculaire 320.34
Formule C₂₀H₁₆O₄
Color White to light yellow
SMILES

O=C1C(C2=CC=C3C(C=CC(C)(C)O3)=C2)=COC4=CC(O)=CC=C14
Structure Classification
- Flavonoids
- Isoflavones
- Phenols
- Monophenols
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (12)

All RT-PCRCell Proliferation/Viability AssayBio/Physico-chemical Assay

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Journal Impact Factor

Acta Pharm Sin B

Chrysin serves as a novel inhibitor of DGK α/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC). [Abstract]

2021 Jan;11(1):143-155. PMID: 33532186
Cell Rep Med

Management of prostate cancer by targeting 3βHSD1 after enzalutamide and abiraterone treatment. [Abstract]

2022 May 17;3(5):100608. PMID: 35584629

Corylin purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2022 May 17;3(5):100608. [Abstract]

Corylin (1 μM) and enzalutamide synergistically inhibited DHEA- but not DHT-induced gene expression in VCaP-Enz cells. DHEA, 100 nM; DHT, 1 nM.

Corylin purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2022 May 17;3(5):100608. [Abstract]

Corylin (5 μM) and enzalutamide synergistically inhibited DHEA- but not DHT-induced cell growth in VCaP-Enz cells. DHEA, 200 nM; DHT, 1 nM.

Corylin purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2022 May 17;3(5):100608. [Abstract]

Daidzein inhibited abiraterone metabolism in VCaP and Huh7 cells, although not as potently as corylin and BCA.
Phytomedicine

Huaier-derived arnicolide D induces ferroptosis in gastric cancer via SRC/TNF-mediated GPX4 inactivation. [Abstract]

2026 May:154:158029. PMID: 41818944

Corylin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2026 May:154:158029. [Abstract]

Cell viability of Arnicolide D, Corylin, Demethyleneberberine and Hirsuteine against GC cells, as evaluated by the CCK8 assays.
Phytomedicine

Corylin inhibits the progression of Non-small cell lung cancer cells by regulating NF-κB signaling pathway via targeting p65. [Abstract]

2023 Feb:110:154627. PMID: 36610351

Corylin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Feb:110:154627. [Abstract]

Effects of different doses of Corylin (0-20 μM) on NF-κB luciferase reporter stimulated by TNF-α.
Food Chem

Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]

2025 Dec 30:497:146992. PMID: 41285060
Food Chem

Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]

2025 May 31:489:144992. PMID: 40466530
J Ethnopharmacol

Discovery of bakuchiol as an AIM2 inflammasome activator and cause of hepatotoxicity. [Abstract]

2022 Nov 15:298:115593. PMID: 35973629
Commun Biol

Exosome-mediated cholesterol flow drives scoliosis progression via promoting the spinal cartilage-bone positive feedback. [Abstract]

2026 Apr 3;9(1):547. PMID: 41933055
Chem Biol Interact

Bavachinin, a main compound of Psoraleae Fructus, facilitates GSDMD-mediated pyroptosis and causes hepatotoxicity in mice. [Abstract]

2024 Jul 3:111133. PMID: 38969277
Naunyn Schmiedebergs Arch Pharmacol

Label-free cell phenotypic profiling of sphingosine-1-phosphate receptor 1 and discovery of its agonist from natural products. [Abstract]

2026 May 29. PMID: 42209736
Transl Cancer Res

Corylin inhibits liver cancer cell growth through the endogenous apoptosis and mitophagy. [Abstract]

2026 Mar 31;15(3):190. PMID: 41969474
Preprints

2026 Mar 23.

Solvant et solubilité

In Vitro:

DMSO : ≥ 100 mg/mL (312.17 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1217 mL

15.6084 mL

31.2168 mL

5 mM

0.6243 mL

3.1217 mL

6.2434 mL

10 mM

0.3122 mL

1.5608 mL

3.1217 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (7.80 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 0.5% CMC-Na/saline water

Solubility: 25 mg/mL (78.04 mM); Suspended solution; Need ultrasonic

Protocol 2

Add each solvent one by one: 15% Cremophor EL 85% Saline

Solubility: 50 mg/mL (156.08 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (277 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Lee SW, et al. Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation. Planta Med. 2012 Jun;78(9):903-6. [Content Brief]

[2]. Chen CY, et al. Corylin Suppresses Hepatocellular Carcinoma Progression via the Inhibition of Epithelial-Mesenchymal Transition, Mediated by Long Noncoding RNA GAS5. Int J Mol Sci. 2018 Jan 27;19(2):380. [Content Brief]

[3]. Chen CC, et al. Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and β3-AR activation. Pharmacol Res. 2021 Feb;164:105291. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.1217 mL	15.6084 mL	31.2168 mL	78.0421 mL
	5 mM	0.6243 mL	3.1217 mL	6.2434 mL	15.6084 mL
	10 mM	0.3122 mL	1.5608 mL	3.1217 mL	7.8042 mL
	15 mM	0.2081 mL	1.0406 mL	2.0811 mL	5.2028 mL
	20 mM	0.1561 mL	0.7804 mL	1.5608 mL	3.9021 mL
	25 mM	0.1249 mL	0.6243 mL	1.2487 mL	3.1217 mL
	30 mM	0.1041 mL	0.5203 mL	1.0406 mL	2.6014 mL
	40 mM	0.0780 mL	0.3902 mL	0.7804 mL	1.9511 mL
	50 mM	0.0624 mL	0.3122 mL	0.6243 mL	1.5608 mL
	60 mM	0.0520 mL	0.2601 mL	0.5203 mL	1.3007 mL
	80 mM	0.0390 mL	0.1951 mL	0.3902 mL	0.9755 mL
	100 mM	0.0312 mL	0.1561 mL	0.3122 mL	0.7804 mL

Keywords

Corylin

12 Cited Publications

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Corylin

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Publications Citing Use of MedChemExpress (MCE) Corylin

Voir tous les produits spécifiques à Isoform Antibiotic

Voir tous les produits spécifiques à Isoform STAT

Activité biologique

Chemical Information

Publications (12)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Corylin Related Classifications

HY-N0236 Related Classifications