Cat. No.: HY-112822

ON-013100

Name: ON-013100
Brand: MedChemExpress
SKU: HY-112822
Price: 100.00 USD
Availability: InStock
Rating: 5 (2 reviews)

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

ON-013100, an antineoplastic agent, acts a mitotic inhibitor that could inhibit Cyclin D1 expression.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté: 99.66%
CAS No.: 865783-95-5
Formule: C₁₉H₂₂O₇S
Masse moléculaire:394.44

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

ON-013100 Chemical Structure

CAS No.: 865783-95-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (2)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

ON-013100, an antineoplastic agent, acts a mitotic inhibitor that could inhibit Cyclin D1 expression.

IC₅₀ & Target^[1]

Cdk4/cyclin D1

Voir tous les produits spécifiques à Isoform CDK :

Cellular Effect

Cell Line	Type	Value	Description	References
2008	IC₅₀	0.005 μM Compound: 6aa	Antitumor activity against human 2008 cells by trypan blue exclusion assay Antitumor activity against human 2008 cells by trypan blue exclusion assay	[PMID: 18088089]
A549	IC₅₀	0.01 μM Compound: 6aa	Antitumor activity against human A549 cells by trypan blue exclusion assay Antitumor activity against human A549 cells by trypan blue exclusion assay	[PMID: 18088089]
AGS	IC₅₀	0.007 μM Compound: 6aa	Antitumor activity against human AGS cells by trypan blue exclusion assay Antitumor activity against human AGS cells by trypan blue exclusion assay	[PMID: 18088089]
BT-20	IC₅₀	0.01 μM Compound: 6aa	Antitumor activity against human BT20 cells by trypan blue exclusion assay Antitumor activity against human BT20 cells by trypan blue exclusion assay	[PMID: 18088089]
CEM/C2	IC₅₀	0.01 μM Compound: 6aa	Antitumor activity against human multidrug-resistant CEM/C2 cells by trypan blue exclusion assay Antitumor activity against human multidrug-resistant CEM/C2 cells by trypan blue exclusion assay	[PMID: 18088089]
COLO 205	IC₅₀	0.009 μM Compound: 6aa	Antitumor activity against human COLO205 cells by trypan blue exclusion assay Antitumor activity against human COLO205 cells by trypan blue exclusion assay	[PMID: 18088089]
Daudi	IC₅₀	0.007 μM Compound: 6aa	Antitumor activity against human Daudi cells by trypan blue exclusion assay Antitumor activity against human Daudi cells by trypan blue exclusion assay	[PMID: 18088089]
DLD-1	IC₅₀	0.003 μM Compound: 6aa	Antitumor activity against human DLD1 cells by trypan blue exclusion assay Antitumor activity against human DLD1 cells by trypan blue exclusion assay	[PMID: 18088089]
DU-145	IC₅₀	0.003 μM Compound: 6aa	Antitumor activity against AR-negative human DU145 cells by trypan blue exclusion assay Antitumor activity against AR-negative human DU145 cells by trypan blue exclusion assay	[PMID: 18088089]
HCT-116	IC₅₀	0.009 μM Compound: 6aa	Antitumor activity against human HCT116 cells by trypan blue exclusion assay Antitumor activity against human HCT116 cells by trypan blue exclusion assay	[PMID: 18088089]
HCT-15	IC₅₀	0.008 μM Compound: 6aa	Antitumor activity against human HCT15 cells by trypan blue exclusion assay Antitumor activity against human HCT15 cells by trypan blue exclusion assay	[PMID: 18088089]
K562	IC₅₀	0.004 μM Compound: 6aa	Antitumor activity against human K562 cells by trypan blue exclusion assay Antitumor activity against human K562 cells by trypan blue exclusion assay	[PMID: 18088089]
MCF7	IC₅₀	0.004 μM Compound: 6aa	Antitumor activity against ER-positive human MCF7 cells by trypan blue exclusion assay Antitumor activity against ER-positive human MCF7 cells by trypan blue exclusion assay	[PMID: 18088089]
MES-SA	IC₅₀	0.006 μM Compound: 6aa	Antitumor activity against human MES-SA cells by trypan blue exclusion assay Antitumor activity against human MES-SA cells by trypan blue exclusion assay	[PMID: 18088089]
MES-SA/Dx5	IC₅₀	0.005 μM Compound: 6aa	Antitumor activity against human multidrug-resistant MES-SA/DX5 cells by trypan blue exclusion assay Antitumor activity against human multidrug-resistant MES-SA/DX5 cells by trypan blue exclusion assay	[PMID: 18088089]
MIA PaCa-2	IC₅₀	0.004 μM Compound: 6aa	Antitumor activity against human MiaPaCa2 cells by trypan blue exclusion assay Antitumor activity against human MiaPaCa2 cells by trypan blue exclusion assay	[PMID: 18088089]
MOLT-4	IC₅₀	0.005 μM Compound: 6aa	Antitumor activity against human MOLT4 cells by trypan blue exclusion assay Antitumor activity against human MOLT4 cells by trypan blue exclusion assay	[PMID: 18088089]
NAMALVA	IC₅₀	0.006 μM Compound: 6aa	Antitumor activity against human Namalwa cells by trypan blue exclusion assay Antitumor activity against human Namalwa cells by trypan blue exclusion assay	[PMID: 18088089]
NCI-H187	IC₅₀	0.007 μM Compound: 6aa	Antitumor activity against human H187 cells by trypan blue exclusion assay Antitumor activity against human H187 cells by trypan blue exclusion assay	[PMID: 18088089]
OVCAR-3	IC₅₀	0.006 μM Compound: 6aa	Antitumor activity against human OVCAR-3 cells by trypan blue exclusion assay Antitumor activity against human OVCAR-3 cells by trypan blue exclusion assay	[PMID: 18088089]
PC-3	IC₅₀	0.008 μM Compound: 6aa	Antitumor activity against AR-positive human PC3 cells by trypan blue exclusion assay Antitumor activity against AR-positive human PC3 cells by trypan blue exclusion assay	[PMID: 18088089]
Raji	IC₅₀	0.004 μM Compound: 6aa	Antitumor activity against human Raji cells by trypan blue exclusion assay Antitumor activity against human Raji cells by trypan blue exclusion assay	[PMID: 18088089]
SK-MEL-28	IC₅₀	0.007 μM Compound: 6aa	Antitumor activity against human SK-MEL-28 cells by trypan blue exclusion assay Antitumor activity against human SK-MEL-28 cells by trypan blue exclusion assay	[PMID: 18088089]
SK-OV-3	IC₅₀	0.006 μM Compound: 6aa	Antitumor activity against human SKOV3 cells by trypan blue exclusion assay Antitumor activity against human SKOV3 cells by trypan blue exclusion assay	[PMID: 18088089]
SW480	IC₅₀	0.007 μM Compound: 6aa	Antitumor activity against human SW480 cells by trypan blue exclusion assay Antitumor activity against human SW480 cells by trypan blue exclusion assay	[PMID: 18088089]
T47D	IC₅₀	0.006 μM Compound: 6aa	Antitumor activity against ER-positive human T47D cells by trypan blue exclusion assay Antitumor activity against ER-positive human T47D cells by trypan blue exclusion assay	[PMID: 18088089]
U-87MG ATCC	IC₅₀	0.007 μM Compound: 6aa	Antitumor activity against human U87 cells by trypan blue exclusion assay Antitumor activity against human U87 cells by trypan blue exclusion assay	[PMID: 18088089]

In Vitro

ON-013100 induces apoptosis, and has activity against most human cancer cell lines in vitro. ON013100 significantly alters the cell cycle profile, dramatically increasing the number of cells in G2/M phase. Treatment of the cells with even 0.1 μM of ON013100 results in an arrest of the G2/M phase of the cell cycle^[2]. ON 013100 inhibits the proliferation of MCL (JEKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines at a nanomolar concentration (ON 013100 GI₅₀=6.7-11.2 nM) ^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 865783-95-5
Appearance Solid
Masse moléculaire 394.44
Formule C₁₉H₂₂O₇S
Color White to off-white
SMILES

OC1=CC(CS(=O)(/C=C/C2=C(OC)C=C(OC)C=C2OC)=O)=CC=C1OC
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

JHEP Rep

MZF1 promotes tumour progression and resistance to anti-PD-L1 antibody treatment in hepatocellular carcinoma. [Abstract]

2023 Oct 25;6(1):100939. PMID: 38074509
Exp Cell Res

NLRP6 suppresses gastric cancer growth via GRP78 ubiquitination. [Abstract]

2020 Oct 1;395(1):112177. PMID: 32682010

Solvant et solubilité

In Vitro:

DMSO : 25 mg/mL (63.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5352 mL

12.6762 mL

25.3524 mL

5 mM

0.5070 mL

2.5352 mL

5.0705 mL

10 mM

0.2535 mL

1.2676 mL

2.5352 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 1.25 mg/mL (3.17 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 1.25 mg/mL.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 1.25 mg/mL (3.17 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 1.25 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Cho SY, et al. Determination of the glucuronide metabolite of ON 013100, a benzylstyrylsulfone antineoplastic drug, in colon cancer cells using LC/MS/MS. J Pharm Biomed Anal. 2013 Mar 5;75:138-44. [Content Brief]

[2]. Park IW, et al. Evaluation of novel cell cycle inhibitors in mantle cell lymphoma. Oncogene. 2007 Aug 16;26(38):5635-42. [Content Brief]

[3]. Neel Jasani, et al. Potent anticancer activity of an orally bioavailable small molecule, ON 013100, and its water soluble derivative, briciclib, a clinical-stage eIF4E-targeted agent. AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5352 mL	12.6762 mL	25.3524 mL	63.3810 mL
	5 mM	0.5070 mL	2.5352 mL	5.0705 mL	12.6762 mL
	10 mM	0.2535 mL	1.2676 mL	2.5352 mL	6.3381 mL
	15 mM	0.1690 mL	0.8451 mL	1.6902 mL	4.2254 mL
	20 mM	0.1268 mL	0.6338 mL	1.2676 mL	3.1690 mL
	25 mM	0.1014 mL	0.5070 mL	1.0141 mL	2.5352 mL
	30 mM	0.0845 mL	0.4225 mL	0.8451 mL	2.1127 mL
	40 mM	0.0634 mL	0.3169 mL	0.6338 mL	1.5845 mL
	50 mM	0.0507 mL	0.2535 mL	0.5070 mL	1.2676 mL
	60 mM	0.0423 mL	0.2113 mL	0.4225 mL	1.0563 mL

Bioz

Keywords

ON-013100

2 Cited Publications

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MCE Japan Authorized Agent:

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CAS No.:
Species:
Pureté:
Quantité:

ON-013100

Ro-3306

Flavopiridol Hydrochloride

LDC4297

Palbociclib isethionate

NU6300

Ribociclib hydrochloride

Ribociclib succinate

Trilaciclib hydrochloride

Lerociclib dihydrochloride

NVP-LCQ195

BS-181 hydrochloride

LY3177833

Publications Citing Use of MedChemExpress (MCE) ON-013100

Voir tous les produits spécifiques à Isoform CDK

Activité biologique

Chemical Information

Publications (2)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Bioz

ON-013100

Ro-3306

Flavopiridol Hydrochloride

LDC4297

Palbociclib isethionate

NU6300

Ribociclib hydrochloride

Ribociclib succinate

Trilaciclib hydrochloride

Lerociclib dihydrochloride

NVP-LCQ195

BS-181 hydrochloride

LY3177833

Publications Citing Use of MedChemExpress (MCE) ON-013100

Voir tous les produits spécifiques à Isoform CDK

Activité biologique

Chemical Information

Publications (2)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

ON-013100 Related Classifications

HY-112822 Related Classifications

Bioz