Communic acid
Communic acid ((+)-Communic acid) is a natural compound isolated from the branches of Platycladus orientalis. Communic acid displays minimum inhibitory concentration of 31 μM and IC50 of 15 μM against M. tuberculosis H37Ra.Communic acid exhibits protective effects against UVB-induced skin aging.
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- CAS No.: 2761-77-5
- Formule: C20H30O2
- Masse moléculaire:302.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
15 μM (M. tuberculosis H37Ra) [2]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>40 μM
Compound: 15
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Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
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[PMID: 23691952] |
| HL-60 | IC50 |
>40 μM
Compound: 15
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Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
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[PMID: 23691952] |
| MCF7 | IC50 |
>40 μM
Compound: 15
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Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
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[PMID: 23691952] |
| SMMC-7721 | IC50 |
>40 μM
Compound: 15
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Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay
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[PMID: 23691952] |
| SW480 | IC50 |
>40 μM
Compound: 15
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Cytotoxicity against human SW480 cells after 48 hrs by MTT assay
Cytotoxicity against human SW480 cells after 48 hrs by MTT assay
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[PMID: 23691952] |
Chemical Information
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CAS No. 2761-77-5
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Masse moléculaire 302.45
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Formule C20H30O2
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SMILES
C[C@@]1([C@H]2C/C=C(C)/C=C)[C@](CCC2=C)([H])[C@](C)(CCC1)C(O)=O
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Synonyms
(+)-Communic acid
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Structure Classification
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Initial Source
Brazilian brown propolis
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Samoylenko V, et al. Antiparasitic, nematicidal and antifouling constituents from Juniperus berries. Phytother Res. 2008;22(12):1570-1576. [Content Brief]
[2]. Carpenter CD, et al. Anti-mycobacterial natural products from the Canadian medicinal plant Juniperus communis. J Ethnopharmacol. 2012;143(2):695-700. [Content Brief]
[3]. Huh WB, et al. Brown Pine Leaf Extract and Its Active Component Trans-Communic Acid Inhibit UVB-Induced MMP-1 Expression by Targeting PI3K. PLoS One. 2015;10(6):e0128365. Published 2015 Jun 11. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Communic acid Related Classifications
HY-N3612 Related Classifications
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