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Cat. No.: HY-168863

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FF2049

FF2049 is a selective HDAC PROTAC degrader (DC₅₀ = 257 nM for HDAC1). FF2049 promotes ubiquitination and degradation of HDAC. FF2049 promotes Apoptosis. FF2049 can be used for the research of hematological and solid cancer.
(Pink: HDAC ligand (HY-168864); Blue: FEM1B ligand (HY-168865); Black: linker (HY-Y0966)).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₃₁H₃₈ClN₇O₇
Masse moléculaire:656.13

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

FF2049 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

FF2049 is a selective HDAC PROTAC degrader (DC₅₀ = 257 nM for HDAC1). FF2049 promotes ubiquitination and degradation of HDAC. FF2049 promotes Apoptosis. FF2049 can be used for the research of hematological and solid cancer^[1]. (Pink: HDAC ligand (HY-168864); Blue: FEM1B ligand (HY-168865); Black: linker (HY-Y0966)).

Voir tous les produits spécifiques à Isoform PROTACs :

Voir tous les produits spécifiques à Isoform HDAC :

Chemical Information

Masse moléculaire 656.13
Formule C₃₁H₃₈ClN₇O₇
SMILES

ONC(CCCCCCNC(C1=CC=C(C=C1)NC(CNC(CN2CCOC3=C2C=CC(N(C(CCl)=O)CCC#N)=C3)=O)=O)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Feller F, et al. Development of the First-in-Class FEM1B-Recruiting Histone Deacetylase Degraders. J Med Chem. 2025 Jan 13. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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FF2049

Voir tous les produits spécifiques à Isoform PROTACs

Voir tous les produits spécifiques à Isoform HDAC

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

FF2049 Related Classifications

HY-168863 Related Classifications