KHK-2898
Based on 1 Customer Validation
KHK-2898 is a monoclonal antibody targeting CD98, which binds to the extracellular domain of CD98 on the tumor cell membrane in a non-covalent antigen-specific mode. KHK-2898 can disrupt the heterodimeric complex formed by CD98 with LAT1 and xCT light chains, reduce the amino acid uptake capacity of tumor cells, block the PI3K/AKT/mTOR proliferative signaling cascade, and mediate antibody-dependent cytotoxicity. KHK-2898 can be used for cancer-related research. The isotype control of KHK-2898 can be found in Human IgG1 kappa, Isotype Control (HY-P99001).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 97.16%
- Masse moléculaire:144.943 kDa
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Stockage:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
[2]|
Akt |
PI3K |
mTOR |
In Vitro
KHK-2898 recognizes the extracellular domain of CD98hc on the surface of tumor cells in a non-covalent antigen-binding manner, which can prevent CD98hc from forming heterodimers with LAT1 and xCT, weaken the tumor cells' ability to take up neutral amino acids and cystine, thereby inhibiting the PI3K/AKT/mTOR proliferative signaling pathway. At the same time, it can trigger antibody-dependent cytotoxicity in tumor cells with high CD98hc expression[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Essai clinique
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Gene ID
Accession
AAH01061
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Application
ELISA, FACS, Functional assay
Chemical Information
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Appearance Liquid
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Masse moléculaire 144.943 kDa
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Color Colorless to light yellow
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Livraison
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KHK-2898 Related Classifications
HY-P990610 Related Classifications
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Keywords
- KHK-2898
- KHK2898
- KHK 2898
- Akt
- mTOR
- PI3K
- monoclonal antibody targeting CD98hc (SLC3A2)
- non-covalent antigen-specific binding
- disrupt CD98hc-LAT1 heterodimer
- disrupt CD98hc-xCT heterodimer
- inhibit amino acid uptake
- block PI3K/AKT/mTOR signaling
- trigger antibody-dependent cellular cytotoxicity (ADCC)
- head and neck squamous cell carcinoma (HNSCC)
- glioblastoma
- colon adenocarcinoma
- pancreatic ductal adenocarcinoma (PDAC)
- non-small cell lung cancer (NSCLC)
- breast cancer
- gastric adenocarcinoma
- tumor xenograft murine model
- Inhibitor
- inhibitor
- inhibit