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Emricasan

(Synonyms: PF 03491390; IDN-6556)
57 Cited Publications
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Based on 57 publication(s) in Google Scholar

Emricasan (PF 03491390) is an orally active and irreversible pan-caspase inhibitor. Emricasan inhibits Zika virus (ZIKV)-induced increases in caspase-3 activity and protected human cortical neural progenitors.

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  • Reinheit: 99.81%
  • CAS. Nr.: 254750-02-2
  • Formel: C26H27F4N3O7
  • Molecular Weight:569.50
  • Speicherung:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Emricasan Chemical Structure
    Emricasan Chemical Structure
  • Experimental Validation Results for Emricasan
  • Experimental Validation Results for Emricasan
  • Experimental Validation Results for Emricasan
  • Experimental Validation Results for Emricasan
  • Experimental Validation Results for Emricasan
  • Experimental Validation Results for Emricasan
CAS. Nr.: 254750-02-2
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Apoptosis AnalysisWBIF
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  • Emricasan Chemical Structure
    Emricasan Chemical Structure
    1/16
  • 1/16

    Emricasan purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2022 Aug;29(8):1486-1499. [Abstract]

    Customer Validation
     Flow cytometry of CD4 and CD8 T cells expressing caspase activity in the absence (Med) or presence of Q-VD-Oph (Q-VD) (10 μM) (Top). Inhibition of caspase activity (preventive effect) in the presence of IDN-6556 (10 μM), VX-765 (10 μM), Q-VD and MCC950. Percentages were calculated as follows: (Med-Inh/Med)*100. Each dot represents one individual (Middle). Flow cytometry of CD4 and CD8 T cells expressing annexin V in the absence (Med) or presence of Q-VD (Bottom).

  • 1/16

    Emricasan purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2019 Jun 5;10(6):442.  [Abstract]

    Customer Validation
     Western blot determined cleavage of caspase-8, -9, -3 in H7N9-infected monocytes treated or untreated with IDN at 3, 6 and 12hpi. β-actin protein is used as the control for sample loading.

  • 1/16

    Emricasan purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2019 Jun 5;10(6):442.  [Abstract]

    Customer Validation
     Morphology examination of infected monocytes with or without IDN treatment at 12hpi. Representative images of immunofluorescence stained influenza A NP protein (green, upper) and bright field (BF, lower) images of the cells.

  • 1/16

    Emricasan purchased from MedChemExpress. Usage Cited in: J Exp Med. 2018 Jul 2;215(7):1839-1852. [Abstract]

    Customer Validation
     Immunoblotting analyses of enteroid cultures treated with 4-OHT for 24 h in the presence of Nec1s or Emricasan or Mock, followed by 0.25 ng/mL TNF for 3 h. Cell lysates are immunoblotted with the antibodies indicated on the right.

  • 1/16

    Emricasan purchased from MedChemExpress. Usage Cited in: J Virol. 2018 Apr 27;92(10). pii: e00078-18. [Abstract]

    Customer Validation
     Cell lysates are collected at day 5 post reactivation and subjected to western blot analysis for p-IRF3 (Ser396), total IRF3, and β-actin (as a loading control).

  • 1/16

    Emricasan purchased from MedChemExpress. Usage Cited in: Nat Protoc. 2015 May;10(5):807-21. [Abstract]

    Customer Validation
     The 18F-FHBG uptake is prohibited after adding the caspase inhibitor IDN6556 during 0.5 μg/mL Dox treatment for 24 h.

  • Emricasan