XAV-939
Based on 190 publication(s) in Google Scholar
XAV-939 is a Tankyrase inhibitor. XAV-939 has inhibitory activity for TNKS1 and TNKS2 with IC50 values of 5 nM and 2 nM, respectively. XAV-939 also is an enhancer of osteoblastic differentiation of hMSCs. XAV-939 can be used for the research of conditions associated with activated Wnt signaling, such as cancer, fibrotic diseases and conditions associated with low bone formation.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.80%
- CAS. Nr.: 284028-89-3
- Formel: C14H11F3N2OS
- Molecular Weight:312.31
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months
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Biologische Aktivität
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Chemical Information
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Cell Cycle/DNA Damage Compound Library
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Publications Citing Use of MedChemExpress (MCE) XAV-939
More- Signal Transduct Target Ther. 2024 Mar 9;9(1):65. [Abstract]
- Signal Transduct Target Ther. 2023 Feb 17;8(1):66. [Abstract]
- Nature. 2022 Jan;601(7894):600-605. [Abstract]
- Cell. 2024 Nov 14;187(23):6566-6583.e22. [Abstract]
- Nat Methods. 2025 Mar;22(3):510-519. [Abstract]
- Sci Bull (Beijing). 2019 Jul 30;64(14):986-997. [Abstract]
- Nat Metab. 2023 Jun;5(6):1014-1028. [Abstract]
- Cell Stem Cell. 2025 Oct 2;32(10):1509-1527.e9. [Abstract]
- Cell Stem Cell. 2025 Mar 6;32(3):409-425.e8. [Abstract]
- Mol Cell. 2025 Sep 18;85(18):3486-3504.e7. [Abstract]
- Nat Protoc. 2026 Jan 26. [Abstract]
- Nat Protoc. 2023 May;18(5):1584-1620. [Abstract]
- Nat Commun. 2025 Dec 12;16(1):11088. [Abstract]
- Nat Commun. 2025 Aug 16;16(1):7638. [Abstract]
- Nat Commun. 2023 Sep 30;14(1):6121. [Abstract]
- Bone Res. 2025 Sep 24;13(1):79. [Abstract]
- Acta Pharm Sin B. 2022 Mar;12(3):1225-1239. [Abstract]
- J Adv Res. 2025 Jul 7:S2090-1232(25)00506-5. [Abstract]
- Cell Discov. 2020 Jun 9;6:35. [Abstract]
- Environ Sci Technol. 2024 Mar 19;58(11):4914-4925. [Abstract]
- Research (Wash D C). 2025 Aug 13:8:0828. [Abstract]
- Cancer Lett. 2024 Nov 28:605:217284. [Abstract]
- Int J Biol Sci. 2024 Sep 16;20(12):4999-5026. [Abstract]
- Int J Biol Sci. 2021 Jun 11;17(10):2449-2460. [Abstract]
- Cell Death Dis. 2021 Jun 25;12(7):650. [Abstract]
- Cell Death Dis. 2020 Mar 30;11(3):206. [Abstract]
- Cell Death Dis. 2020 Jan 6;11(1):9. [Abstract]
- Cell Death Dis. 2018 Jan 18;9(2):27. [Abstract]
- Sci China Life Sci. 2025 Apr 22. [Abstract]
- Genome Biol. 2024 Mar 4;25(1):64. [Abstract]
- Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2009539118. [Abstract]
- Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1898-906. [Abstract]
- Int J Biol Macromol. 2024 Jul 3:133639. [Abstract]
- Acta Pharmacol Sin. 2023 May;44(5):940-953. [Abstract]
- Phytomedicine. 2024 May 8:130:155687. [Abstract]
- Phytomedicine. 2024 Jun:128:155419. [Abstract]
- Phytomedicine. 2023 Sep:118:154933. [Abstract]
- EMBO Mol Med. 2023 Jun 7;15(6):e17101. [Abstract]
- ACS Appl Mater Interfaces. 2025 Jul 2;17(26):38333-38347. [Abstract]
- Free Radic Biol Med. 2025 Apr:231:178-192. [Abstract]
- Neoplasia. 2024 Dec 30:60:101096. [Abstract]
- Brain Behav Immun. 2021 May:94:327-337. [Abstract]
- J Transl Med. 2024 Feb 3;22(1):133. [Abstract]
- J Transl Med. 2021 Oct 9;19(1):417. [Abstract]
- Biomed Pharmacother. 2018 Mar:99:319-324. [Abstract]
- Europace. 2022 Dec 9;24(12):2015-2027. [Abstract]
- Stem Cell Res Ther. 2025 Sep 1;16(1):479. [Abstract]
- Oncogene. 2025 Jun;44(23):1820-1832. [Abstract]
- Stem Cell Res Ther. 2024 Nov 15;15(1):431. [Abstract]
- Stem Cell Res Ther. 2020 Jun 17;11(1):240. [Abstract]
- PLoS Biol. 2026 Mar 4;24(3):e3003700. [Abstract]
- Aging Cell. 2026 Jan 20;25(2):e70352.
- Cell Death Discov. 2024 Mar 9;10(1):123. [Abstract]
- Cell Rep. 2022 Feb 1;38(5):110319. [Abstract]
- Neurotherapeutics. 2021 Jan;18(1):601-614. [Abstract]
- Neural Regen Res. 2025 Sep 29. [Abstract]
- NPJ Regen Med. 2021 Sep 6;6(1):51. [Abstract]
- Mol Med. 2025 Feb 4;31(1):41. [Abstract]
- Oncoimmunology. 2025 Dec 31;14(1):2595360. [Abstract]
- Cell Biosci. 2025 Oct 2;15(1):130. [Abstract]
- Ecotoxicol Environ Saf. 2025 Mar 1:292:117930. [Abstract]
- Hum Reprod. 2024 Nov 1:deae246. [Abstract]
- Ecotoxicol Environ Saf. 2023 Jan 1:249:114410. [Abstract]
- Cancer Cell Int. 2021 Dec 4;21(1):648. [Abstract]
- J Mol Cell Biol. 2025 Dec 5:mjaf050. [Abstract]
- J Mol Cell Biol. 2025 Jul 28;17(2):mjaf002. [Abstract]
- Front Immunol. 2021 Mar 15:12:619209. [Abstract]
- J Invest Dermatol. 2019 Jan;139(1):224-234. [Abstract]
- Colloids Surf B Biointerfaces. 2019 Oct 1:182:110332. [Abstract]
- Am J Chin Med. 2025;53(7):2223-2243. [Abstract]
- J Ethnopharmacol. 2026 Apr 6:360:121188. [Abstract]
- Foods. 2024 Apr 12;13(8):1171. [Abstract]
- Glia. 2023 Feb;71(2):284-304. [Abstract]
- Life Sci. 2020 Oct 1;258:118143. [Abstract]
- Life Sci. 2019 Oct 15;235:116844. [Abstract]
- Respir Res. 2022 Mar 25;23(1):70. [Abstract]
- J Nutr Biochem. 2025 Dec 1;149:110214.
- Int J Mol Sci. 2024 Apr 9;25(8):4138. [Abstract]
- Int J Mol Sci. 2023 Apr 4;24(7):6733. [Abstract]
- Int J Mol Sci. 2023 Apr 6;24(7):6826. [Abstract]
- Cell Oncol (Dordr). 2025 Aug;48(4):1127-1144. [Abstract]
- Cell Mol Neurobiol. 2023 Nov;43(8):4117-4140. [Abstract]
- Front Pharmacol. 2018 Jun 21:9:660. [Abstract]
- Eur J Pharmacol. 2026 Feb 15:1015:178541. [Abstract]
- Invest Ophthalmol Vis Sci. 2025 Jan 2;66(1):8. [Abstract]
- Int Immunopharmacol. 2024 Nov 14;143(Pt 3):113580. [Abstract]
- ACS Appl Bio Mater. 2021 Mar 15;4(3):2601-2613. [Abstract]
- Bioscience Rep. 2020 Feb 28;40(2):BSR20191248. [Abstract]
- Toxicology. 2024 Aug 21:153932. [Abstract]
- BMC Biol. 2020 Oct 27;18(1):151. [Abstract]
- Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1971-1977. [Abstract]
- Mol Neurobiol. 2024 Jan;61(1):308-325. [Abstract]
- ACS Omega. 2023 Jun 16;8(26):23683-23694. [Abstract]
- Poult Sci. 2026 Mar 5;105(6):106738. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2025 Aug 8;1871(8):168013. [Abstract]
- FASEB J. 2025 Aug 31;39(16):e70975. [Abstract]
- Exp Neurol. 2024 Dec 3:115086. [Abstract]
- J Cell Mol Med. 2023 Mar;27(5):659-671. [Abstract]
- Bioengineered. 2022 May;13(5):12516-12531. [Abstract]
- Bioengineered. 2022 Feb;13(2):2207-2216. [Abstract]
- Lab Invest. 2021 Sep;101(9):1130-1141. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2490-2503. [Abstract]
- J Mol Med (Berl). 2019 Aug;97(8):1183-1193. [Abstract]
- Oncol Res. 2025 Dec 30;34(1):16. [Abstract]
- iScience. 2024 Jun 8;27(7):110221. [Abstract]
- J Inflamm Res. 2021 May 14:14:1945-1957. [Abstract]
- J Cell Physiol. 2020 Mar;235(3):2149-2160. [Abstract]
- J Cell Physiol. 2019 Jul;234(7):10386-10396. [Abstract]
- J Biol Chem. 2026 Mar 16;302(5):111368. [Abstract]
- Sci Rep. 2025 Jul 18;15(1):26176. [Abstract]
- Prog Neuropsychopharmacol Biol Psychiatry. 2024 Feb 8:129:110874. [Abstract]
- Oncol Rep. 2023 Jul;50(1):134. [Abstract]
- Oncol Rep. 2022 Nov;48(5):204. [Abstract]
- Aging (Albany NY). 2021 Sep 23;13(18):22528-22543. [Abstract]
- Cell Signal. 2026 Feb:138:112259. [Abstract]
- Cell Signal. 2026 Feb:138:112220. [Abstract]
- Brain Res Bull. 2023 Oct 1:202:110734. [Abstract]
- Cell Signal. 2022 Jan:89:110181. [Abstract]
- Biochim Biophys Acta. 2016 Dec;1859(12):1527-1537. [Abstract]
- Development. 2026 Feb 23:dev.204903. [Abstract]
- Heliyon. 2024 Mar 7;10(6):e27727. [Abstract]
- Am J Pathol. 2020 Nov;190(11):2237-2250. [Abstract]
- Development. 2017 Nov 1;144(21):3894-3906. [Abstract]
- Regen Ther. 2025 Aug 13:30:584-594. [Abstract]
- Food Chem Toxicol. 2025 Oct:204:115628. [Abstract]
- Mol Med Rep. 2022 Jan;25(1):2. [Abstract]
- Mol Med Rep. 2020 Dec;22(6):5023-5032. [Abstract]
- Wound Repair Regen. 2025 May-Jun;33(3):e70032. [Abstract]
- Toxicol Appl Pharmacol. 2023 May 15:467:116492. [Abstract]
- Cell Cycle. 2022 Feb;21(4):352-367. [Abstract]
- Am J Physiol Renal Physiol. 2020 Sep 1;319(3):F458-F468. [Abstract]
- J Immunol. 2019 Aug 15;203(4):922-935. [Abstract]
- Stem Cells Int. 2021 Sep 11:2021:8359582. [Abstract]
- Cell Transplant. 2023 Jan-Dec:32:9636897231212746. [Abstract]
- J Cancer. 2021 Aug 28;12(21):6320-6329. [Abstract]
- Front Biosci (Landmark Ed). 2025 Sep 25;30(9):43853. [Abstract]
- Cell Biol Int. 2024 May;48(5):647-664. [Abstract]
- Cancer Med. 2023 Apr;12(7):9005-9023. [Abstract]
- Mol Immunol. 2023 Jan:153:60-74. [Abstract]
- J Bioenerg Biomembr. 2021 Oct;53(5):597-608. [Abstract]
- Arch Biochem Biophys. 2019 Nov 15;676:108137. [Abstract]
- Discov Oncol. 2025 Oct 21;16(1):1926. [Abstract]
- Discov Oncol. 2025 Jan 20;16(1):63. [Abstract]
- Toxicol Lett. 2023 Sep 15:387:1-13. [Abstract]
- Am J Cancer Res. 2022 Mar 15;12(3):1069-1087. [Abstract]
- Free Radic Res. 2020 Oct;54(10):722-731. [Abstract]
- Technol Cancer Res Treat. 2026 Jan-Dec:25:15330338261425407. [Abstract]
- J Cancer Res Clin Oncol. 2024 Jul 29;150(7):373. [Abstract]
- J Orthop Surg Res. 2021 Oct 30;16(1):650. [Abstract]
- J Cancer Res Clin Oncol. 2021 Apr;147(4):1101-1113. [Abstract]
- Animals (Basel). 2024 May 4;14(9):1382. [Abstract]
- Exp Biol Med. 2022 Sep;247(17):1548-1557. [Abstract]
- Antibodies. 2019 Jan 10;8(1):10. [Abstract]
- Brain Res. 2024 Jan 1:1822:148637. [Abstract]
- PLoS One. 2020 Nov 2;15(11):e0239119. [Abstract]
- J Radiat Res Appl Sci. 2023 Jun.
- Reprod Sci. 2021 Oct;28(10):2906-2915. [Abstract]
- Exp Ther Med. 2021 Oct;22(4):1137. [Abstract]
- Biomed Res Int. 2017:2017:1972608. [Abstract]
- J Mol Histol. 2025 Apr 1;56(2):125. [Abstract]
- J Bone Miner Metab. 2022 May;40(3):448-459. [Abstract]
- Oncol Lett. 2021 Aug;22(2):586. [Abstract]
- Oncol Lett. 2019 Sep;18(3):2537-2547. [Abstract]
- Biochem Biophys Res Commun. 2018 Sep 10;503(3):2061-2067. [Abstract]
- Anticancer Drugs. 2018 Mar;29(3):208-215. [Abstract]
- Cell Physiol Biochem. 2016;39(1):360-70. [Abstract]
- Comp Biochem Phys B. 2016 Jan;191:155-62. [Abstract]
- Curr Med Sci. 2024 Aug;44(4):789-798. [Abstract]
- J Spinal Cord Med. 2024 Sep;47(5):669-680. [Abstract]
- Int Ophthalmol. 2023 May;43(5):1687-1699. [Abstract]
- Biosci Biotechnol Biochem. 2019 Jun;83(6):1035-1044. [Abstract]
- Northwestern University. 2026.
- medRxiv. 2026 Mar 7.
- bioRxiv. 2025 Dec 24.
- bioRxiv. 2025 Jun 22.
- bioRxiv. 2025 May 14.
- Methods Mol Biol. 2025 May 17. [Abstract]
- SSRN. 2025 May 27.
- Methods Mol Biol. 2025 May 22. [Abstract]
- bioRxiv. 2024 Apr 12.
- bioRxiv. 2024 Feb 27.
- Research Square Preprint. 2023 May 17.
- bioRxiv. 2023 Feb 10.
- J Oncol. 2022 Sep 26;2022:3659714. [Abstract]
- Research Square Preprint. 2022 May.
- Research Square Preprint. 2022 Jan.
- Research Square Preprint. 2021 May.
- Research Square Preprint. 2020 Nov.
- Patent. US20180263995A1.
- Oncotarget. 2017 Jul 22;8(41):69924-69933. [Abstract]
Customer Validation & Images
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WB
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2D/3D Cell Culture and Differentiation
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IF
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WB
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WB
Biologische Aktivität
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TNKS2 2 nM (IC50) |
TNKS1 5 nM (IC50) |
ARTD2 479 nM (IC50) |
ARTD1 5500 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
12.3 μM
Compound: XAV939
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Growth inhibition of human A549 cells after 72 hrs by MTT assay
Growth inhibition of human A549 cells after 72 hrs by MTT assay
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[PMID: 29934219] |
| COLO 320DM | GI50 |
17 μM
Compound: XAV939
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Antiproliferative activity against human COLO320DM cells assessed as inhibition of cell growth measured after 4 days by CellTiter-Glo assay
Antiproliferative activity against human COLO320DM cells assessed as inhibition of cell growth measured after 4 days by CellTiter-Glo assay
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[PMID: 30883102] |
| DLD-1 | IC50 |
0.707 μM
Compound: 1, XAV-939
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Inhibition of tankyrase in human DLD1 cells assessed as reduction in Wnt activity after 24 hrs by TCF-luciferase reporter gene assay
Inhibition of tankyrase in human DLD1 cells assessed as reduction in Wnt activity after 24 hrs by TCF-luciferase reporter gene assay
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[PMID: 25299683] |
| HEK293 | IC50 |
0.078 μM
Compound: 1, XAV939
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Inhibition of mouse Wnt3A signaling in human HEK293 cells after 1 day by super top flash luciferase reporter gene assay
Inhibition of mouse Wnt3A signaling in human HEK293 cells after 1 day by super top flash luciferase reporter gene assay
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[PMID: 22260203] |
| HEK293 | IC50 |
0.078 μM
Compound: 1, XAV939
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Inhibition of WNT3A signaling in HEK293 cells by luciferase reporter gene assay in presence of forskolin
Inhibition of WNT3A signaling in HEK293 cells by luciferase reporter gene assay in presence of forskolin
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[PMID: 23844574] |
| HEK293 | IC50 |
0.078 μM
Compound: 1, XAV939
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Inhibition of Wnt signaling in human HEK293 cells assessed as inhibition of forskolin-induced cAMP response element activation by STF luciferase reporter gene assay
Inhibition of Wnt signaling in human HEK293 cells assessed as inhibition of forskolin-induced cAMP response element activation by STF luciferase reporter gene assay
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[PMID: 23879431] |
| HEK293 | IC50 |
272 μM
Compound: 3, XAV939
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Inhibition of Tankyrase in human HEK293 cells assessed as inhibition of Wnt pathway by Wnt3a-induced STF assay
Inhibition of Tankyrase in human HEK293 cells assessed as inhibition of Wnt pathway by Wnt3a-induced STF assay
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[PMID: 23316926] |
| HEK-293T | IC50 |
51 nM
Compound: 2, XAV939
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Inhibition of beta-casein-dependent canonical Wnt3 pathway in human HEK293T cells by luciferase reporter gene assay
Inhibition of beta-casein-dependent canonical Wnt3 pathway in human HEK293T cells by luciferase reporter gene assay
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[PMID: 22191557] |
| Sf21 | IC50 |
0.0053 μM
Compound: 1, XAV939
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Inhibition of N-terminal GST-tagged TNKS2 (unknown origin) expressed in baculovirus infected sf21 cells after 60 mins by LC-MS analysis
Inhibition of N-terminal GST-tagged TNKS2 (unknown origin) expressed in baculovirus infected sf21 cells after 60 mins by LC-MS analysis
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[PMID: 23879431] |
| Sf21 | IC50 |
17 nM
Compound: 5; XAV939
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Inhibition of N-terminal GST-tagged human TNKS-2 (849 to 1166 residues) expressed in in insect sf21 cells preincubated for 2 hrs followed by substrate addition measured after 30 mins
Inhibition of N-terminal GST-tagged human TNKS-2 (849 to 1166 residues) expressed in in insect sf21 cells preincubated for 2 hrs followed by substrate addition measured after 30 mins
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[PMID: 27163581] |
| Sf9 | IC50 |
2.1 nM
Compound: XAV939
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Inhibition of human N-terminal GST-tagged TNKS2 (667 to 1166 residues) expressed in baculovirus infected Sf9 insect cells using histone as substrate measured after 1 hr by horseradish peroxidase-coupled chemiluminescence assay
Inhibition of human N-terminal GST-tagged TNKS2 (667 to 1166 residues) expressed in baculovirus infected Sf9 insect cells using histone as substrate measured after 1 hr by horseradish peroxidase-coupled chemiluminescence assay
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[PMID: 31042381] |
| Sf9 | IC50 |
4.2 nM
Compound: XAV939
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Inhibition of human N-terminal GST-tagged TNKS1 (1001 to 1327 residues) expressed in baculovirus infected Sf9 insect cells using histone as substrate measured after 1 hr by horseradish peroxidase-coupled chemiluminescence assay
Inhibition of human N-terminal GST-tagged TNKS1 (1001 to 1327 residues) expressed in baculovirus infected Sf9 insect cells using histone as substrate measured after 1 hr by horseradish peroxidase-coupled chemiluminescence assay
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[PMID: 31042381] |
| SW480 | EC50 |
0.371 μM
Compound: 1, XAV939
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Stabilization of Axin2 in human SW480 cells after 24 hrs by sandwich ELISA
Stabilization of Axin2 in human SW480 cells after 24 hrs by sandwich ELISA
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[PMID: 22260203] |
| SW480 | GI50 |
>50 μM
Compound: XAV939
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Growth inhibition of human SW480 cells by Cell-titer-fluor reagent based assay
Growth inhibition of human SW480 cells by Cell-titer-fluor reagent based assay
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[PMID: 31769984] |
XAV-939 has activity against TNKS1 and TNKS2 with IC50 values of 5 nM and 2 nM, respectively[1].
XAV-939 (0.3-30 μM; 3 or 10 days) enhances osteoblast differentiation of hBMSCs[2].
XAV-939 (3 μM) promotes osteoblast differentiation of hMSCs via accumulation of SH3BP2[2].
XAV-939 (3 μM; 10 days) upregulates the expression of OPG and downregulates the expression of RANKL in hBMSCs during osteoblast differentiation[2].
XAV-939 suppresses Wnt/β-catenin signaling and promotes SFRP3 and SFRP4 expression[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:hMSC-TERT cell line
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Concentration:0.3, 3, and 30 μM
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Incubation Time:3 days
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Result:Showed no significant effect on proliferation at day 1, 2, and 3 at dose of 0.3 and 3 μM but inhibited hMSCs cell proliferation on day 3 at dose of 30 μM.
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Cell Line:hMSC-TERT cell line
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Concentration:3 µM
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Incubation Time:3 days
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Result:Showed a minute percentage of cell death (apoptosis and necrosis) in the XAV-939-treated hBMSC
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Cell Line:hMSC-TERT cell line
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Concentration:3 µM
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Incubation Time:10 days
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Result:Upregulated gene expression of osteoblast-associated gene markers including: ALP, COL1A1, RUNX2, and OC.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 284028-89-3
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Appearance Solid
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Molecular Weight 312.31
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Formel C14H11F3N2OS
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Color White to off-white
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SMILES
O=C1C(CSCC2)=C2N=C(C3=CC=C(C(F)(F)F)C=C3)N1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 1 year -20°C 6 months
Publications (190)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Tet methylcytosine dioxygenase 2 (TET2) deficiency elicits EGFR-TKI (tyrosine kinase inhibitors) resistance in non-small cell lung cancer. [Abstract]2024 Mar 9;9(1):65. PMID: 38461173 -
Signal Transduct Target Ther
B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-catenin. [Abstract]2023 Feb 17;8(1):66. PMID: 36797256 -
Nature
2022 Jan;601(7894):600-605. PMID: 34856602
XAV-939 purchased from MedChemExpress. Usage Cited in: Nature. 2022 Jan;601(7894):600-605. [Abstract]
Upon exposure to lysophosphatidic acid (LPA) (a Hippo pathway inhibitor), A83-01 (an inhibitor of TGFβ family receptors) and PD0325901 (an ERK inhibitor) in a chemically defined medium containing the STAT activator leukaemia inhibitory factor (LIF) and Y-27632 (a ROCK inhibitor) (10 µM, 7 days),blastocyst-like structures formed efficiently from naive PSCs.
XAV-939 purchased from MedChemExpress. Usage Cited in: Nature. 2022 Jan;601(7894):600-605. [Abstract]
Upon exposure to lysophosphatidic acid (LPA) (a Hippo pathway inhibitor), A83-01 (an inhibitor of TGFβ family receptors) and PD0325901 (an ERK inhibitor) in a chemically defined medium containing the STAT activator leukaemia inhibitory factor (LIF) and Y-27632 (a ROCK inhibitor) (10 µM, 7 days), blastocyst-like structures formed efficiently from naive PSCs. trophectoderm (TE) cell analogues (identified as GATA2+GATA3+CDX2+TROP2+) formed, proliferated, and established adherens junctions (marked by CDH1), apical-basal polarity (indicated by aPKC) and tight junctions (marked by ZO-1).
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Cell
2024 Nov 14;187(23):6566-6583.e22. PMID: 39332412 -
Nat Methods
Challenging the Astral mass analyzer to quantify up to 5,300 proteins per single cell at unseen accuracy to uncover cellular heterogeneity. [Abstract]2025 Mar;22(3):510-519. PMID: 39820751 -
Sci Bull (Beijing)
TRIM28 protects CARM1 from proteasome-mediated degradation to prevent colorectal cancer metastasis. [Abstract]2019 Jul 30;64(14):986-997. PMID: 36659810 -
Nat Metab
2023 Jun;5(6):1014-1028. PMID: 37337125 -
Cell Stem Cell
An inducible model of human post-implantation development derived from primed and naive stem cells. [Abstract]2025 Oct 2;32(10):1509-1527.e9. PMID: 40885193 -
Cell Stem Cell
Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts. [Abstract]2025 Mar 6;32(3):409-425.e8. PMID: 39814012 -
Mol Cell
mTOR inhibition reprograms cellular lipid homeostasis by inducing alternative lipid uptake and promoting cholesterol transport. [Abstract]2025 Sep 18;85(18):3486-3504.e7. PMID: 40972529 -
Nat Protoc
2026 Jan 26. PMID: 41588252 -
Nat Protoc
2023 May;18(5):1584-1620. PMID: 36792779 -
Nat Commun
Imaging mitochondrial membrane potential via concentration-dependent fluorescence lifetime changes. [Abstract]2025 Dec 12;16(1):11088. PMID: 41387403 -
Nat Commun
2025 Aug 16;16(1):7638. PMID: 40819131 -
Nat Commun
Heat-inactivated Bifidobacterium adolescentis ameliorates colon senescence through Paneth-like-cell-mediated stem cell activation. [Abstract]2023 Sep 30;14(1):6121. PMID: 37777508 -
Bone Res
Mechanism of Piezo1 regulating chondrocyte mitochondrial function and promoting fracture healing through β-catenin/LARS2 signaling pathway. [Abstract]2025 Sep 24;13(1):79. PMID: 40993116 -
Acta Pharm Sin B
WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit. [Abstract]2022 Mar;12(3):1225-1239. PMID: 35530152 -
J Adv Res
Tankyrase activity is essential for asymmetric division and chromosome segregation in oocyte meiosis. [Abstract]2025 Jul 7:S2090-1232(25)00506-5. PMID: 40633837 -
Cell Discov
A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer. [Abstract]2020 Jun 9;6:35. PMID: 32550000 -
Environ Sci Technol
Mixed Metal Components in PM2.5 Contribute to Chemokine Receptor CCR5-Mediated Neuroinflammation and Neuropathological Changes in the Mouse Olfactory Bulb. [Abstract]2024 Mar 19;58(11):4914-4925. PMID: 38436231 -
Research (Wash D C)
Isovalerylspiramycin I Reprograms the Immunosuppressive and Temozolomide-Resistant Microenvironment by Inhibiting the Frizzled-5/Wnt/β-Catenin Pathway in Glioblastoma. [Abstract]2025 Aug 13:8:0828. PMID: 40809457 -
Cancer Lett
Exploring epigenetic dynamics unveils a super-enhancer-mediated NDRG1-β-catenin axis in modulating gemcitabine resistance in pancreatic cancer. [Abstract]2024 Nov 28:605:217284. PMID: 39366545 -
Int J Biol Sci
RUNX1-MUC13 Interaction Activates Wnt/β-Catenin Signaling Implications for Colorectal Cancer Metastasis. [Abstract]2024 Sep 16;20(12):4999-5026. PMID: 39309442 -
Int J Biol Sci
Combination of Ferulic Acid, Ligustrazine and Tetrahydropalmatine attenuates Epithelial-mesenchymal Transformation via Wnt/β-catenin Pathway in Endometriosis. [Abstract]2021 Jun 11;17(10):2449-2460. PMID: 34326686 -
Cell Death Dis
CT45A1 promotes the metastasis of osteosarcoma cells in vitro and in vivo through β-catenin. [Abstract]2021 Jun 25;12(7):650. PMID: 34172717 -
Cell Death Dis
PCDHGA9 represses epithelial-mesenchymal transition and metastatic potential in gastric cancer cells by reducing β-catenin transcriptional activity. [Abstract]2020 Mar 30;11(3):206. PMID: 32231199 -
Cell Death Dis
Oligodendrocyte precursor cells transplantation protects blood-brain barrier in a mouse model of brain ischemia via Wnt/β-catenin signaling. [Abstract]2020 Jan 6;11(1):9. PMID: 31907363 -
Cell Death Dis
PCDHGA9 acts as a tumor suppressor to induce tumor cell apoptosis and autophagy and inhibit the EMT process in human gastric cancer. [Abstract]2018 Jan 18;9(2):27. PMID: 29348665
XAV-939 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Jan 18;9(2):27. [Abstract]
The cellular locations of β-catenin are detected by western blot. GAPDH, Histone H3, and ATP1A1 are used to normalize protein expression in total lysates and nuclear and membrane fractions, respectively. SGC-7901 cells with PCDHGA9 overexpression or vector control cells are grown in media with or without 10 μg/mL inhibitor of β-catenin (XAV-939).
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Sci China Life Sci
Maternal transcription factor OTX2 directly induces SETD1A and promotes embryonic genome activation in human pre-implantation embryos. [Abstract]2025 Apr 22. PMID: 40285911 -
Genome Biol
Early-life ruminal microbiome-derived indole-3-carboxaldehyde and prostaglandin D2 are effective promoters of rumen development. [Abstract]2024 Mar 4;25(1):64. PMID: 38438919 -
Proc Natl Acad Sci U S A
2021 Jan 12;118(2):e2009539118. PMID: 33376206 -
Proc Natl Acad Sci U S A
Soluble (pro)renin receptor via β-catenin enhances urine concentration capability as a target of liver X receptor. [Abstract]2016 Mar 29;113(13):E1898-906. PMID: 26984496
XAV-939 purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1898-906. [Abstract]
Analysis of the in vitro role of the Wnt/β–catenin pathway in the regulation of AQP2 expression in response to sPRR-His treatment. Effect of XAV on sPRR-His-induced AQP2 expression (n = 6 per group).
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Int J Biol Macromol
GSK3 regulation Wnt/β-catenin signaling affects adipogenesis in bovine skeletal muscle fibro/adipogenic progenitors. [Abstract]2024 Jul 3:133639. PMID: 38969042 -
Acta Pharmacol Sin
Inhibiting von Hippel‒Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism. [Abstract]2023 May;44(5):940-953. PMID: 36357669 -
Phytomedicine
Icariside II modulates pulmonary fibrosis via PI3K/Akt/β-catenin pathway inhibition of M2 macrophage program. [Abstract]2024 May 8:130:155687. PMID: 38759312 -
Phytomedicine
Dahuang-Wumei decoction protects against hepatic encephalopathy in mice: Behavioural, biochemical, and molecular evidence. [Abstract]2024 Jun:128:155419. PMID: 38522314 -
Phytomedicine
Quercetin induces MGMT+ glioblastoma cells apoptosis via dual inhibition of Wnt3a/β-Catenin and Akt/NF-κB signaling pathways. [Abstract]2023 Sep:118:154933. PMID: 37451151 -
EMBO Mol Med
Axin2 coupled excessive Wnt-glycolysis signaling mediates social defect in autism spectrum disorders. [Abstract]2023 Jun 7;15(6):e17101. PMID: 37078424
XAV-939 purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2023 Jun 7;15(6):e17101. [Abstract]
XAV939 (20 μM; 3 days) restores the expression of Homer1, PSD95, and GluR1 in Shank3 knockout (KO) human neurons.
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ACS Appl Mater Interfaces
A Multimodal Nanoplatform Integrating Photodynamic Therapy and Wnt/β-Catenin Inhibition Reprograms the Tumor Microenvironment to Potentiate Immune Checkpoint Therapy in Triple-Negative Breast Cancer. [Abstract]2025 Jul 2;17(26):38333-38347. PMID: 40525603 -
Free Radic Biol Med
MSC exosomes and MSC exosomes loaded with LncRNA H19 as nanotherapeutics regulate the neurogenetic potential of Müller Glial Cells in dry age-related macular degeneration. [Abstract]2025 Apr:231:178-192. PMID: 40015462 -
Neoplasia
β-Catenin mediated TAM phenotype promotes pancreatic cancer metastasis via the OSM/STAT3/LOXL2 axis. [Abstract]2024 Dec 30:60:101096. PMID: 39740539 -
Brain Behav Immun
Ghrelin modulates dopaminergic neuron formation and attention deficit hyperactivity disorder-like behaviors: From animals to human models. [Abstract]2021 May:94:327-337. PMID: 33412253 -
J Transl Med
Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer. [Abstract]2024 Feb 3;22(1):133. PMID: 38310229 -
J Transl Med
CENPA promotes clear cell renal cell carcinoma progression and metastasis via Wnt/β-catenin signaling pathway. [Abstract]2021 Oct 9;19(1):417. PMID: 34627268 -
Biomed Pharmacother
Geraniin promotes osteoblast proliferation and differentiation via the activation of Wnt/β-catenin pathway. [Abstract]2018 Mar:99:319-324. PMID: 29353207 -
Europace
The G213D variant in Nav1.5 alters sodium current and causes an arrhythmogenic phenotype resulting in a multifocal ectopic Purkinje-related premature contraction phenotype in human-induced pluripotent stem cell-derived cardiomyocytes. [Abstract]2022 Dec 9;24(12):2015-2027. PMID: 35726875 -
Stem Cell Res Ther
2025 Sep 1;16(1):479. PMID: 40890876 -
Oncogene
Rictor orchestrates β-catenin/FOXO balance by maintaining redox homeostasis during development of ovarian cancer. [Abstract]2025 Jun;44(23):1820-1832. PMID: 40133477 -
Stem Cell Res Ther
AGEs impair osteogenesis in orthodontic force-induced periodontal ligament stem cells through the KDM6B/Wnt self-reinforcing loop. [Abstract]2024 Nov 15;15(1):431. PMID: 39548506 -
Stem Cell Res Ther
Long noncoding RNA LINC00314 facilitates osteogenic differentiation of adipose-derived stem cells through the hsa-miR-129-5p/GRM5 axis via the Wnt signaling pathway. [Abstract]2020 Jun 17;11(1):240. PMID: 32552820 -
PLoS Biol
2026 Mar 4;24(3):e3003700. PMID: 41779769 -
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Cell Death Discov
2024 Mar 9;10(1):123. PMID: 38461207 -
Cell Rep
Liquidambaric acid inhibits Wnt/β-catenin signaling and colon cancer via targeting TNF receptor-associated factor 2. [Abstract]2022 Feb 1;38(5):110319. PMID: 35108540 -
Neurotherapeutics
Blockers of Wnt3a, Wnt10a, or β-Catenin Prevent Chemotherapy-Induced Neuropathic Pain In Vivo. [Abstract]2021 Jan;18(1):601-614. PMID: 33128175 -
Neural Regen Res
Hedgehog signaling activation rescues hypoxia-induced ferroptosis in human brain organoids. [Abstract]2025 Sep 29. PMID: 41017694 -
NPJ Regen Med
Cyclic pulsation stress promotes bone formation of tissue engineered laminae through the F-actin/YAP-1/β-Catenin signaling axis. [Abstract]2021 Sep 6;6(1):51. PMID: 34489466 -
Mol Med
Mechanistic insights into 5-aminolevulinic acid photodynamic therapy for acne vulgaris: targeting lipogenesis via the OLR1-Wnt/β-catenin pathway. [Abstract]2025 Feb 4;31(1):41. PMID: 39905294 -
Oncoimmunology
Wnt3a-expressing cancer stem cells impair CD8+ TRM function, contributing to immunotherapy resistance in Melanoma. [Abstract]2025 Dec 31;14(1):2595360. PMID: 41340472 -
Cell Biosci
The miR-34/449 clusters regulate the differentiation of ciliated cells in the oviduct via the Wnt/β-catenin signaling pathway. [Abstract]2025 Oct 2;15(1):130. PMID: 41039637 -
Ecotoxicol Environ Saf
Polyhexamethylene guanidine phosphate induces epithelial-to-mesenchymal transition and cancer stem cell-like properties via Wnt/β-catenin signaling in human bronchial epithelial cells. [Abstract]2025 Mar 1:292:117930. PMID: 39986058 -
Hum Reprod
CDC42 deficiency leads to endometrial stromal cell senescence in recurrent implantation failure. [Abstract]2024 Nov 1:deae246. PMID: 39487595 -
Ecotoxicol Environ Saf
A2aR inhibits fibrosis and the EMT process in silicosis by regulating Wnt/β-catenin pathway. [Abstract]2023 Jan 1:249:114410. PMID: 36516619
XAV-939 purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2023 Jan 1:249:114410. [Abstract]
XAV-939 (5 μM) significantly decreases the expression level of β-catenin in A549 cells.
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Cancer Cell Int
CCR9 initiates epithelial-mesenchymal transition by activating Wnt/β-catenin pathways to promote osteosarcoma metastasis. [Abstract]2021 Dec 4;21(1):648. PMID: 34863167 -
J Mol Cell Biol
Canonical Wnt signaling affects calcium homeostasis in serum-treated AC16 cells through MLN-mediated SERCA2a regulation. [Abstract]2025 Dec 5:mjaf050. PMID: 41348974 -
J Mol Cell Biol
Wnt/β-catenin pathway induces cardiac dysfunction via AKAP6-mediated RyR2 phosphorylation and sarcoplasmic reticulum calcium leakage. [Abstract]2025 Jul 28;17(2):mjaf002. PMID: 40097291 -
Front Immunol
Wnt Inhibition Sensitizes PD-L1 Blockade Therapy by Overcoming Bone Marrow-Derived Myofibroblasts-Mediated Immune Resistance in Tumors. [Abstract]2021 Mar 15:12:619209. PMID: 33790893 -
J Invest Dermatol
2019 Jan;139(1):224-234. PMID: 30081003 -
Colloids Surf B Biointerfaces
2019 Oct 1:182:110332. PMID: 31325776 -
Am J Chin Med
Notoginsenoside R1 Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Apoptosis via Activating Wnt/β-Catenin Signaling. [Abstract]2025;53(7):2223-2243. PMID: 40926715 -
J Ethnopharmacol
Diankuang Mengxing Decoction exerts neuroprotective effects in post-stroke depression by mediating the activation of the Wnt/β-catenin pathway via TREM2. [Abstract]2026 Apr 6:360:121188. PMID: 41534750 -
Foods
Hawthorn Proanthocyanidin Extract Inhibits Colorectal Carcinoma Metastasis by Targeting the Epithelial-Mesenchymal Transition Process and Wnt/β-Catenin Signaling Pathway. [Abstract]2024 Apr 12;13(8):1171. PMID: 38672844 -
Glia
Remyelination in neuromyelitis optica spectrum disorder is promoted by edaravone through mTORC1 signaling activation. [Abstract]2023 Feb;71(2):284-304. PMID: 36089914 -
Life Sci
Kaempferol promotes proliferation and osteogenic differentiation of periodontal ligament stem cells via Wnt/β-catenin signaling pathway. [Abstract]2020 Oct 1;258:118143. PMID: 32717269 -
Life Sci
XQ-1H alleviates cerebral ischemia in mice through inhibition of apoptosis and promotion of neurogenesis in a Wnt/β-catenin signaling dependent way. [Abstract]2019 Oct 15;235:116844. PMID: 31499069 -
Respir Res
Impaired AT2 to AT1 cell transition in PM2.5-induced mouse model of chronic obstructive pulmonary disease. [Abstract]2022 Mar 25;23(1):70. PMID: 35337337 -
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Int J Mol Sci
Small Molecules Promote the Rapid Generation of Dental Epithelial Cells from Human-Induced Pluripotent Stem Cells. [Abstract]2024 Apr 9;25(8):4138. PMID: 38673725 -
Int J Mol Sci
2023 Apr 4;24(7):6733. PMID: 37047705 -
Int J Mol Sci
Stearoyl-CoA Desaturases1 Accelerates Non-Small Cell Lung Cancer Metastasis by Promoting Aromatase Expression to Improve Estrogen Synthesis. [Abstract]2023 Apr 6;24(7):6826. PMID: 37047797 -
Cell Oncol (Dordr)
SPTSSA facilitates gastric cancer progression with modulating PD-L1 in immunomicroenvironment through Wnt/β-catenin pathway. [Abstract]2025 Aug;48(4):1127-1144. PMID: 40498284 -
Cell Mol Neurobiol
Neuroprotective Effect of Hydrogen Sulfide Subchronic Treatment Against TBI-Induced Ferroptosis and Cognitive Deficits Mediated Through Wnt Signaling Pathway. [Abstract]2023 Nov;43(8):4117-4140. PMID: 37624470 -
Front Pharmacol
2018 Jun 21:9:660. PMID: 29977207
XAV-939 purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Jun 21:9:660. [Abstract]
By Western blotting, the α-SMA and palladin proteins are determined in cells that are pretreated with NF-κB (JSH-23), Wnt/β-catenin (XAV939), EGFR (CP-358774), p38 MAPK (TAK-715), and Smad3 (SIS3) inhibitors and are followed by TWEAK stimulation.
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Eur J Pharmacol
Melatonin suppresses cellular senescence in diabetic kidney disease though the Wnt/β-catenin signaling pathway. [Abstract]2026 Feb 15:1015:178541. PMID: 41534557 -
Invest Ophthalmol Vis Sci
RSPO3 Promotes Proliferation and Self-Renewal of Limbal Epithelial Stem Cells Through a WNT/β-Catenin-Independent Signaling Pathway. [Abstract]2025 Jan 2;66(1):8. PMID: 39760688 -
Int Immunopharmacol
Evidence of the "hit and run" characteristics of Cerebroprotein Hydrolysate-I in the treatment of neonatal HIE based on pharmacokinetic and pharmacological studies. [Abstract]2024 Nov 14;143(Pt 3):113580. PMID: 39547013 -
ACS Appl Bio Mater
Hyaluronic Acid Hydrogel with Adjustable Stiffness for Mesenchymal Stem Cell 3D Culture via Related Molecular Mechanisms to Maintain Stemness and Induce Cartilage Differentiation. [Abstract]2021 Mar 15;4(3):2601-2613. PMID: 35014377 -
Bioscience Rep
Wnt10b promotes hair follicles growth and dermal papilla cells proliferation via Wnt/β-Catenin signaling pathway in Rex rabbits. [Abstract]2020 Feb 28;40(2):BSR20191248. PMID: 31961392 -
Toxicology
Mutual regulation between histone methyltransferase Suv39h1 and the Wnt/β-catenin signaling pathway promoted cell proliferation and inhibited apoptosis in bone marrow mesenchymal stem cells exposed to hydroquinone. [Abstract]2024 Aug 21:153932. PMID: 39179171 -
BMC Biol
Hyperactivated Wnt-β-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2. [Abstract]2020 Oct 27;18(1):151. PMID: 33109217 -
Artif Cells Nanomed Biotechnol
2019 Dec;47(1):1971-1977. PMID: 31155960 -
Mol Neurobiol
Regulation of Microglial Activation by Wnt/β-Catenin Signaling After Global Cerebral Ischemia in Mice. [Abstract]2024 Jan;61(1):308-325. PMID: 37607993 -
ACS Omega
MGST1 Expression Is Associated with Poor Prognosis, Enhancing the Wnt/β-Catenin Pathway via Regulating AKT and Inhibiting Ferroptosis in Gastric Cancer. [Abstract]2023 Jun 16;8(26):23683-23694. PMID: 37426275 -
Poult Sci
Downregulation of the host ribonucleotide reductase subunit M2 via the Wnt/β-catenin pathway is a novel mechanism for duck plague virus replication and a potential antiviral target. [Abstract]2026 Mar 5;105(6):106738. PMID: 41850058 -
Biochim Biophys Acta Mol Basis Dis
Glioma cells produce soluble PD-L1 via the Wnt/β-catenin signaling pathway to suppress CD8+ T cell activity. [Abstract]2025 Aug 8;1871(8):168013. PMID: 40784599 -
FASEB J
DACT3-DVL1 Interaction-Mediated Canonical WNT Signaling Regulates Non-Small Cell Lung Cancer Progression and Cisplatin Resistance. [Abstract]2025 Aug 31;39(16):e70975. PMID: 40838391 -
Exp Neurol
Inhibition of histamine receptor 3 alleviates sevoflurane-induced hypomyelination and neurobehavioral deficits. [Abstract]2024 Dec 3:115086. PMID: 39637962 -
J Cell Mol Med
ASPP2 suppresses tumour growth and stemness characteristics in HCC by inhibiting Warburg effect via WNT/β-catenin/HK2 axis. [Abstract]2023 Mar;27(5):659-671. PMID: 36752127 -
Bioengineered
Transcriptional factor 3 binds to sirtuin 1 to activate the Wnt/β-catenin signaling in cervical cancer. [Abstract]2022 May;13(5):12516-12531. PMID: 35587604 -
Bioengineered
DNA topoisomerase II alpha promotes the metastatic characteristics of glioma cells by transcriptionally activating β-catenin. [Abstract]2022 Feb;13(2):2207-2216. PMID: 35012441 -
Lab Invest
PHLDA3 promotes lung adenocarcinoma cell proliferation and invasion via activation of the Wnt signaling pathway. [Abstract]2021 Sep;101(9):1130-1141. PMID: 34006890 -
Biochim Biophys Acta Mol Basis Dis
EGR1 promotes the cartilage degeneration and hypertrophy by activating the Krüppel-like factor 5 and β-catenin signaling. [Abstract]2019 Sep 1;1865(9):2490-2503. PMID: 31201921 -
J Mol Med (Berl)
2019 Aug;97(8):1183-1193. PMID: 31201471 -
Oncol Res
2025 Dec 30;34(1):16. PMID: 41502529 -
iScience
RHOF activation of AKT/β-catenin signaling pathway drives acute myeloid leukemia progression and chemotherapy resistance. [Abstract]2024 Jun 8;27(7):110221. PMID: 39021805 -
J Inflamm Res
Lentivirus-Mediated Overexpression or Silencing of Aquaporin 1 Affects the Proliferation, Migration and Invasion of TNF-α-Stimulated Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Wnt/β-Catenin Signaling Pathway. [Abstract]2021 May 14:14:1945-1957. PMID: 34017191 -
J Cell Physiol
miR-222 inhibits cardiac fibrosis in diabetic mice heart via regulating Wnt/β-catenin-mediated endothelium to mesenchymal transition. [Abstract]2020 Mar;235(3):2149-2160. PMID: 31389030 -
J Cell Physiol
Long-noncoding RNA HOTAIR inhibits immunologic rejection of mouse leukemia cells through activating the Wnt/β-catenin signaling pathway in a mouse model of leukemia. [Abstract]2019 Jul;234(7):10386-10396. PMID: 30609034 -
J Biol Chem
IFIT3-DVL interaction promotes malignant progression of lung squamous cell carcinoma and large-cell lung carcinoma via canonical WNT signaling. [Abstract]2026 Mar 16;302(5):111368. PMID: 41850400 -
Sci Rep
KLF5-regulated ZDHHC8 reduces chemosensitivity in high-grade serous ovarian cancer through β-catenin signaling. [Abstract]2025 Jul 18;15(1):26176. PMID: 40681764 -
Prog Neuropsychopharmacol Biol Psychiatry
Transcriptome profile of reserpine-induced locomotor behavioral changes in zebrafish (Danio rerio). [Abstract]2024 Feb 8:129:110874. PMID: 37839537 -
Oncol Rep
FOXD1 promotes chemotherapy resistance by enhancing cell stemness in colorectal cancer through β‑catenin nuclear localization. [Abstract]2023 Jul;50(1):134. PMID: 37203394 -
Oncol Rep
OTX1 promotes tumorigenesis and progression of cervical cancer by regulating the Wnt signaling pathway. [Abstract]2022 Nov;48(5):204. PMID: 36177903 -
Aging (Albany NY)
Inhibition of FSTL3 abates the proliferation and metastasis of renal cell carcinoma via the GSK-3β/β-catenin signaling pathway. [Abstract]2021 Sep 23;13(18):22528-22543. PMID: 34555811 -
Cell Signal
COL1A1 promotes clear cell renal cell carcinoma progression through the Wnt/β-catenin signaling pathway. [Abstract]2026 Feb:138:112259. PMID: 41270811 -
Cell Signal
Akt-Axin1/TNKS-Tiam1-Rac1 mediates insulin-stimulated GLUT4 translocation in skeletal muscle cells. [Abstract]2026 Feb:138:112220. PMID: 41207648 -
Brain Res Bull
Electroacupuncture alleviates PTSD-like behaviors by modulating hippocampal synaptic plasticity via Wnt/β-catenin signaling pathway. [Abstract]2023 Oct 1:202:110734. PMID: 37586426 -
Cell Signal
2022 Jan:89:110181. PMID: 34757019 -
Biochim Biophys Acta
2016 Dec;1859(12):1527-1537. PMID: 27717711 -
Development
2026 Feb 23:dev.204903. PMID: 41725360 -
Heliyon
EP300 regulates the SLC16A1-AS1-AS1/TCF3 axis to promote lung cancer malignancies through the Wnt signaling pathway. [Abstract]2024 Mar 7;10(6):e27727. PMID: 38515708 -
Am J Pathol
Insulin Promotes Corneal Nerve Repair and Wound Healing in Type 1 Diabetic Mice by Enhancing Wnt/β-Catenin Signaling. [Abstract]2020 Nov;190(11):2237-2250. PMID: 32858016 -
Development
Anteroposterior polarity and elongation in the absence of extra-embryonic tissues and of spatially localised signalling in gastruloids: mammalian embryonic organoids. [Abstract]2017 Nov 1;144(21):3894-3906. PMID: 28951435 -
Regen Ther
Tanshinone IIA suppresses fibro-adipogenic progenitor differentiation and attenuates fat infiltration in rotator cuff injury via Wnt/β-catenin pathway. [Abstract]2025 Aug 13:30:584-594. PMID: 40837862 -
Food Chem Toxicol
Mechanistic insights into AKT1/GSK3β/CD36 axis regulation in ZLY06-induced hepatic lipid metabolism dysfunction and protective intervention via AKT activation strategies. [Abstract]2025 Oct:204:115628. PMID: 40633829 -
Mol Med Rep
Cancer‑associated fibroblast‑derived LRRC15 promotes the migration and invasion of triple‑negative breast cancer cells via Wnt/β‑catenin signalling pathway regulation. [Abstract]2022 Jan;25(1):2. PMID: 34726255 -
Mol Med Rep
1,25(OH)2D3 inhibits osteogenic differentiation through activating β‑catenin signaling via downregulating bone morphogenetic protein 2. [Abstract]2020 Dec;22(6):5023-5032. PMID: 33173996 -
Wound Repair Regen
TWEAK regulates the functions of hair follicle stem cells via the Fn14-Wnt/β-catenin-CXCR4 signalling axis. [Abstract]2025 May-Jun;33(3):e70032. PMID: 40325995 -
Toxicol Appl Pharmacol
Guanine nucleotide exchange factor T exerts the cancer-promoting function in cholangiocarcinoma by enhancing the Wnt-GSK-3β-β-catenin cascade via regulation of Rac1/Cdc42. [Abstract]2023 May 15:467:116492. PMID: 36977438 -
Cell Cycle
Human bone marrow-mesenchymal stem cell-derived exosomal microRNA-188 reduces bronchial smooth muscle cell proliferation in asthma through suppressing the JARID2/Wnt/β-catenin axis. [Abstract]2022 Feb;21(4):352-367. PMID: 34974799 -
Am J Physiol Renal Physiol
Liraglutide suppresses production of extracellular matrix proteins and ameliorates renal injury of diabetic nephropathy by enhancing Wnt/β-catenin signaling. [Abstract]2020 Sep 1;319(3):F458-F468. PMID: 32715762
XAV-939 purchased from MedChemExpress. Usage Cited in: Am J Physiol Renal Physiol. 2020 Sep 1;319(3):F458-F468. [Abstract]
Representative Western blot showing FN protein abundance in HMCs cultured in media containing NG or HG in the absence or presence of liraglutide (100 nM) or DMSO (1:1000) or XAV-939 (5 μM) for 24 h.
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J Immunol
IL-36γ Promotes Killing of Mycobacterium tuberculosis by Macrophages via WNT5A-Induced Noncanonical WNT Signaling. [Abstract]2019 Aug 15;203(4):922-935. PMID: 31235551 -
Stem Cells Int
Wnt/ β-Catenin Pathway Balances Scaffold Degradation and Bone Formation in Tissue-Engineered Laminae. [Abstract]2021 Sep 11:2021:8359582. PMID: 34552633 -
Cell Transplant
Telocyte-Derived Exosomes Provide an Important Source of Wnts That Inhibits Fibrosis and Supports Regeneration and Repair of Endometrium. [Abstract]2023 Jan-Dec:32:9636897231212746. PMID: 38006220 -
J Cancer
FAM83A Promotes the Proliferative and Invasive Abilities of Cervical Cancer Cells via Epithelial-Mesenchymal Transition and the Wnt Signaling Pathway. [Abstract]2021 Aug 28;12(21):6320-6329. PMID: 34659522 -
Front Biosci (Landmark Ed)
Notch1 Inhibition Exacerbates APAP-Induced Liver Injury via β-Catenin and Macrophage Polarization. [Abstract]2025 Sep 25;30(9):43853. PMID: 41074446 -
Cell Biol Int
Histological study of telocytes in mice intrauterine adhesion model and their positive effect on mesenchymal stem cells in vitro. [Abstract]2024 May;48(5):647-664. PMID: 38353345 -
Cancer Med
LINC00669 promotes lung adenocarcinoma growth by stimulating the Wnt/β-catenin signaling pathway. [Abstract]2023 Apr;12(7):9005-9023. PMID: 36621836 -
Mol Immunol
Reserve of Wnt/β-catenin Signaling Alleviates Mycoplasma pneumoniae P1-C-induced Inflammation in airway epithelial cells and lungs of mice. [Abstract]2023 Jan:153:60-74. PMID: 36444819 -
J Bioenerg Biomembr
HOXC13 promotes cervical cancer proliferation, invasion and Warburg effect through β-catenin/c-Myc signaling pathway. [Abstract]2021 Oct;53(5):597-608. PMID: 34309767 -
Arch Biochem Biophys
Fusion of macrophages promotes breast cancer cell proliferation, migration and invasion through activating epithelial-mesenchymal transition and Wnt/β-catenin signaling pathway. [Abstract]2019 Nov 15;676:108137. PMID: 31605677 -
Discov Oncol
2025 Oct 21;16(1):1926. PMID: 41118012 -
Discov Oncol
Nonylphenol promotes epithelial-mesenchymal transition in colorectal cancer cells by upregulating miR-151a-3p. [Abstract]2025 Jan 20;16(1):63. PMID: 39832042 -
Toxicol Lett
Bavachin induces liver injury and cell apoptosis by targeting Wnt/β-catenin/DRP1 signaling pathway mediated mitochondrial dysfunction. [Abstract]2023 Sep 15:387:1-13. PMID: 37748667 -
Am J Cancer Res
TNKS inhibitors potentiate proliferative inhibition of BET inhibitors via reducing β-Catenin in colorectal cancer cells. [Abstract]2022 Mar 15;12(3):1069-1087. PMID: 35411247 -
Free Radic Res
Protective effect of bone marrow mesenchymal stem cell-derived exosomes on cardiomyoblast hypoxia-reperfusion injury through the miR-149/let-7c/Faslg axis. [Abstract]2020 Oct;54(10):722-731. PMID: 33054503 -
Technol Cancer Res Treat
β-Catenin-Facilitated Glycolytic Reprogramming Fuels TNBC Progression: Therapeutic Blockade with XAV939. [Abstract]2026 Jan-Dec:25:15330338261425407. PMID: 41700965 -
J Cancer Res Clin Oncol
Regulatory T cells inhibit FoxP3 to increase the population of tumor initiating cells in hepatocellular carcinoma. [Abstract]2024 Jul 29;150(7):373. PMID: 39073490 -
J Orthop Surg Res
Protective effects of low-magnitude high-frequency vibration on high glucose-induced osteoblast dysfunction and bone loss in diabetic rats. [Abstract]2021 Oct 30;16(1):650. PMID: 34717702 -
J Cancer Res Clin Oncol
Resveratrol induces PD-L1 expression through snail-driven activation of Wnt pathway in lung cancer cells. [Abstract]2021 Apr;147(4):1101-1113. PMID: 33471184 -
Animals (Basel)
The Effect of Inhibiting the Wingless/Integrated (WNT) Signaling Pathway on the Early Embryonic Disc Cell Culture in Chickens. [Abstract]2024 May 4;14(9):1382. PMID: 38731386 -
Exp Biol Med
The β-catenin/CBP signaling axis participates in sepsis-induced inflammatory lung injury. [Abstract]2022 Sep;247(17):1548-1557. PMID: 35665630 -
Antibodies
A Strategy to Optimize the Generation of Stable Chromobody Cell Lines for Visualization and Quantification of Endogenous Proteins in Living Cells. [Abstract]2019 Jan 10;8(1):10. PMID: 31544816 -
Brain Res
Wnt-3a improves functional recovery after spinal cord injury by regulating the inflammatory and apoptotic response in rats via wnt/β-catenin signaling pathway. [Abstract]2024 Jan 1:1822:148637. PMID: 37858855 -
PLoS One
Interferon Regulatory Factor-1 (IRF1) activates autophagy to promote liver ischemia/reperfusion injury by inhibiting β-catenin in mice. [Abstract]2020 Nov 2;15(11):e0239119. PMID: 33137133 -
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Reprod Sci
POSTN Promotes the Proliferation of Spermatogonial Cells by Activating the Wnt/β-Catenin Signaling Pathway. [Abstract]2021 Oct;28(10):2906-2915. PMID: 33959891 -
Exp Ther Med
2021 Oct;22(4):1137. PMID: 34466147 -
Biomed Res Int
The Neuroprotective Effects of Muscle-Derived Stem Cells via Brain-Derived Neurotrophic Factor in Spinal Cord Injury Model. [Abstract]2017:2017:1972608. PMID: 28758111
XAV-939 purchased from MedChemExpress. Usage Cited in: Biomed Res Int. 2017:2017:1972608. [Abstract]
To investigate the roles of β-catenin, XAV939 (β-catenin inhibitor) was added to MNT group. Total protein is used to observe the expression of Nrf2 and LC3.
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J Mol Histol
Blue light-emitting diode promotes mineralization of stem cells from the apical papilla via cryptochrome 1/Wnt/β-catenin signaling. [Abstract]2025 Apr 1;56(2):125. PMID: 40167571 -
J Bone Miner Metab
Enamel matrix derivative expedites osteogenic differentiation of BMSCs via Wnt/β-catenin pathway in high glucose microenvironment. [Abstract]2022 May;40(3):448-459. PMID: 35347430 -
Oncol Lett
Small interfering-high mobility group A2 attenuates epithelial-mesenchymal transition in thymic cancer cells via the Wnt/β-catenin pathway. [Abstract]2021 Aug;22(2):586. PMID: 34122637 -
Oncol Lett
Detection and clinical significance of circulating tumor cells in patients with nasopharyngeal carcinoma. [Abstract]2019 Sep;18(3):2537-2547. PMID: 31452741 -
Biochem Biophys Res Commun
Down-regulated lncRNA MEG3 promotes osteogenic differentiation of human dental follicle stem cells by epigenetically regulating Wnt pathway. [Abstract]2018 Sep 10;503(3):2061-2067. PMID: 30103943
XAV-939 purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2018 Sep 10;503(3):2061-2067. [Abstract]
Western blot analysis and alizarin red staining of hDFSCs transfected by EZH2-siRNA and treated by XAV-939. DMSO is used as a vehicle control.
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Anticancer Drugs
Sonic hedgehog and Wnt/β-catenin pathways mediate curcumin inhibition of breast cancer stem cells. [Abstract]2018 Mar;29(3):208-215. PMID: 29356693
XAV-939 purchased from MedChemExpress. Usage Cited in: Anticancer Drugs. 2018 Mar;29(3):208-215. [Abstract]
SUM159 sphereforming cells are treated with 15 μM XAV-939 for 7 days, and the protein expression levels of breast cancer stem cells (CSCs) markers are detected by western blotting.
XAV-939 purchased from MedChemExpress. Usage Cited in: Anticancer Drugs. 2018 Mar;29(3):208-215. [Abstract]
SUM159 sphere-forming cells are treated with GDC-0449 (15 μM), a Smoothened (Smo) inhibitor for 7 days, and the protein expression levels of breast cancer stem cells (CSCs) play markers are detected by western blotting.
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Cell Physiol Biochem
Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/β-Catenin Signaling. [Abstract]2016;39(1):360-70. PMID: 27352380
XAV-939 purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2016;39(1):360-70. [Abstract]
EGF upregulates the expression of follicle-regulatory genes via Wnt/β-catenin signaling pathway. (A) The mRNA and (B, C) the protein levels of Survivin, Msx2 and SGK3 in the ORS cells with EGF treatment/overexpression and/or XAV-939 treatment.
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Comp Biochem Phys B
Wnt/β-catenin signaling participates in the regulation of lipogenesis in the liver of juvenile turbot (Scophthalmus maximus L.). [Abstract]2016 Jan;191:155-62. PMID: 26545985
XAV-939 purchased from MedChemExpress. Usage Cited in: Comp Biochem Phys B. 2016 Jan;191:155-62. [Abstract]
The protein expression of Wnt10b and p-GSK-3β is significantly induced by LiCl treatment (A and B). Nevertheless, XAV939 treatment significantly inhibits the protein expression of p-GSK-3β (B). Moreover, the protein expression of p-β-catenin is significantly inhibited by LiCl treatment, but significantly induced by XAV939 treatment (C).
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Curr Med Sci
Silencing MFN2 Drives WNT/β-catenin Nucleation to Reduce Sorafenib Sensitivity in Hepatocellular Carcinoma Cells. [Abstract]2024 Aug;44(4):789-798. PMID: 38926329 -
J Spinal Cord Med
Protocatechuic aldehyde promotes the functional recovery of spinal cord injury by activating the Wnt/β-catenin signaling pathway. [Abstract]2024 Sep;47(5):669-680. PMID: 36913540 -
Int Ophthalmol
β-asarone attenuates the proliferation, migration and enhances apoptosis of retinoblastoma through Wnt/β-catenin signaling pathway. [Abstract]2023 May;43(5):1687-1699. PMID: 36372820 -
Biosci Biotechnol Biochem
MicroRNA-543 promotes cell invasion and impedes apoptosis in pituitary adenoma via activating the Wnt/β-catenin pathway by negative regulation of Smad7. [Abstract]2019 Jun;83(6):1035-1044. PMID: 30973065 -
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Methods Mol Biol
2025 May 17. PMID: 40377872 -
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Methods Mol Biol
Generation of Human Naïve Pluripotent Stem Cell-Derived Blastoids in Thermoformed Microwell Platforms. [Abstract]2025 May 22. PMID: 40397283 -
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J Oncol
2022 Sep 26;2022:3659714. PMID: 36199799 -
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Oncotarget
Opposing roles of ICAT and Wnt/β-catenin signaling in NSC67657-induced monocytic differentiation. [Abstract]2017 Jul 22;8(41):69924-69933. PMID: 29050252
Lösungsmittel & Löslichkeit
DMSO : 15.62 mg/mL (50.01 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 1.56 mg/mL (5.00 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 1.56 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (15.6 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 1.56 mg/mL (5.00 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 1.56 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (15.6 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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-
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (279 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Mohit Narwal, et al. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem. 2013 Oct 24;56(20):7880-9. [Content Brief]
[2]. Nuha Almasoud, et al. Tankyrase inhibitor XAV-939 enhances osteoblastogenesis and mineralization of human skeletal (mesenchymal) stem cells. Sci Rep. 2020 Oct 7;10(1):16746. [Content Brief]
[3]. Senxin Cai, et al. Mechanical stress reduces secreted frizzled-related protein expression and promotes temporomandibular joint osteoarthritis via Wnt/β-catenin signaling. Bone. 2022 Aug;161:116445. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2019 mL | 16.0097 mL | 32.0195 mL | 80.0487 mL |
| 5 mM | 0.6404 mL | 3.2019 mL | 6.4039 mL | 16.0097 mL | |
| 10 mM | 0.3202 mL | 1.6010 mL | 3.2019 mL | 8.0049 mL | |
| 15 mM | 0.2135 mL | 1.0673 mL | 2.1346 mL | 5.3366 mL | |
| 20 mM | 0.1601 mL | 0.8005 mL | 1.6010 mL | 4.0024 mL | |
| 25 mM | 0.1281 mL | 0.6404 mL | 1.2808 mL | 3.2019 mL | |
| 30 mM | 0.1067 mL | 0.5337 mL | 1.0673 mL | 2.6683 mL | |
| 40 mM | 0.0800 mL | 0.4002 mL | 0.8005 mL | 2.0012 mL | |
| 50 mM | 0.0640 mL | 0.3202 mL | 0.6404 mL | 1.6010 mL |
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