GNE-5472
GNE-5472 is a potent bifunctional ERα PRRTAC degrader, with its E3 ligand being a pan-IAP antagonist. GNE-5472 antagonizes cIAP1/2, activating the non-classical NF-κB pathway, resulting in a significant upregulation of TNFα expression. GNE-5472 inhibits the proliferation of breast cancer cells and induces cell apoptosis. GNE-5472 can be used for the study of breast cancer.
(Pink: Estrogen Receptor/ERR ligand (HY-18719); Blue: IAP ligand (HY-175446); Black: linker).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 2417369-99-2
- Formel: C59H73N7O9S
- Molecular Weight:1056.32
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Alle PROTACs Isoform-spezifische Produkte anzeigen
MoreAlle TNF Receptor Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
|
ERα |
cIAP1 |
cIAP-2 |
NF-κB |
Chemical Information
-
CAS. Nr. 2417369-99-2
-
Molecular Weight 1056.32
-
Formel C59H73N7O9S
-
SMILES
CC/C(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)/C3=CC=C(C=C3)OCCN(C(CCOCCOCCC(NC4=NC(C5=CC=CC=C5)=C(NC([C@@H]6CCCN6C([C@@H](NC([C@H](C)NC)=O)C7CCCCC7)=O)=O)S4)=O)=O)C
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
GNE-5472 Related Classifications
HY-175445 Related Classifications
Powered by Bioz