HDAC6-IN-71
HDAC6-IN-71 (Compound 24) is a HDAC6 inhibitor with IC50 values for HDAC6 and HDAC1 of 13.68 and 443.12 nM respectively. HDAC6-IN-71 effectively inhibits the production of NO by mouse macrophages, with its IC50 being 2.31 μM. HDAC6-IN-71 inhibits the HDAC6-NF-κB signaling pathway, reduces the levels of phosphorylated IκB-α and IKK-α/β, and suppresses the expression of downstream inflammatory proteins COX-2 and iNOS. HDAC6-IN-71 significantly alleviates ulcerative colitis in mice.
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- CAS. Nr.: 3062867-16-4
- Formel: C18H13NO5
- Molecular Weight:323.30
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
|
HDAC6 13.68 nM (IC50) |
HDAC1 443.12 nM (IC50) |
NF-κB |
IKK-α |
IKK-β |
COX-2 |
iNOS |
Chemical Information
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CAS. Nr. 3062867-16-4
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Molecular Weight 323.30
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Formel C18H13NO5
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SMILES
O=C(NO)/C=C/C1=CC=C(C=C1)OC2=CC(OC3=CC=CC=C32)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
HDAC6-IN-71 Related Classifications
HY-180829 Related Classifications
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